Method for preparing polysiloxane hydrogel with high moisture content

A polysiloxane and hydrogel technology, used in medical science, instruments, glasses/goggles, etc., can solve the problems of inability to obtain wearing comfort, short-term comfort effect, discomfort, etc., and improve surface wettability. Poor, reducing the effect of water loss rate

Inactive Publication Date: 2012-09-19
FAR EASTERN NEW CENTURY COPRRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these physical methods can successfully improve the wetting effect of the surface of the contact lens, they cannot effectively increase the moisture content of the contact lens itself, resulting in only a short-term comfort when wearing the contact lens improved by the above methods effect, but cannot obtain long-term wearing comfort
[0007] As far as comfort is concerned, long-term wear of contact lenses often results in dry, uncomfortable eyes due to the rapid loss of water from the lenses, insufficient tear supply from the lacrimal glands, or prolonged contact with the outside world. Moisture loss due to exposure to air
The above conditions may cause contact lens wearers to experience dry eyes, or may even cause poor vision problems

Method used

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  • Method for preparing polysiloxane hydrogel with high moisture content
  • Method for preparing polysiloxane hydrogel with high moisture content
  • Method for preparing polysiloxane hydrogel with high moisture content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] synthetic chemicals

[0049] 1. 2-Hydroxyethyl methacrylate (HEMA for short): Purchased from Sigma.

[0050] 2. N-vinylpyrrolidone (NVP for short): Purchased from Sigma.

[0051] 3. Methacrylic acid (MA): Purchased from Sigma.

[0052] 4. (Trimethylsilyloxy)-3-methacryloxypropylsilane (TRIS): Purchased from Sigma.

[0053] 5. CoatOsil: Purchased from Momentive.

[0054] 6. Ethylene glycol dimethacrylate (EGDMA): Purchased from Sigma Corporation.

[0055] 7. D1173 photoinitiator: purchased from Ciba Chemicals.

[0056] Preparation of polysiloxane hydrogel materials

example 1

[0058] According to the composition and content shown in formula 1 in Table 1, the components were uniformly mixed, and cross-linked and polymerized by ultraviolet light for 60 minutes, and the completed polymer was soaked in 50% alcohol for 20 minutes, and then extracted with 70% alcohol for 60 minutes. minutes to remove unreacted monomer. Soak the prepared polysiloxane hydrogel film in sodium bicarbonate (NaHCO 3 ) solution for 60 minutes, then soaked in normal saline for 60 minutes for replacement, and finally placed the obtained film in normal saline and soaked for 120 minutes to reach the balance of water content.

example 2

[0060] The same feed ratio and reaction conditions as in Example 1, but the prepared polysiloxane hydrogel film was soaked in a sodium hydroxide (NaOH) solution with a pH of 9 for 60 minutes, and then soaked in physiological saline for 60 minutes. Replacement is carried out, and finally the obtained film is placed in physiological saline and soaked for 120 minutes to reach the balance of water content.

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Abstract

The invention provides a method for preparing polysiloxane hydrogel with high moisture content. The method includes the following steps: polymerizing monomer mixtures to form the polysiloxane hydrogel, wherein the monomer mixtures comprise at least one silicon-containing monomer and at least one ionic monomer; and placing the polysiloxane hydrogel into an alkaline solution for at least 20 minutes, wherein, the PH of the alkaline solution is not smaller than 7.5, and the content of the ionic monomer is no less than 0.7 wt. % of total weight of overall polysiloxane hydrogel dry weight.

Description

technical field [0001] The present invention relates to methods of making ophthalmic articles. In particular, the present invention relates to a method of making silicone hydrogels with high water content. Background technique [0002] Contact lenses have been developed for nearly a hundred years and are one of the important medical devices commonly used by the general eyewear family. In the 1950s, Czech scientists invented soft contact lenses using poly(hydroxyethyl methacrylate; HEMA) materials to make hydrogels, which are still used today. With the advancement of technology, the evolution of contact lens materials is also developing towards high oxygen permeability and high comfort. [0003] The development of contact lenses made of silicone hydrogel has a history of many years. In the past, the development goals of these products were mainly to improve the oxygen permeability and water content of silicone hydrogel. The oxygen permeability value of the polysiloxane hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/00C08F290/06C08F220/28C08F226/10C08F220/06C08F230/08C08F222/14A61L27/16G02C7/04
Inventor 张根源李致达黄锦平张怡萱
Owner FAR EASTERN NEW CENTURY COPRRATION
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