The invention discloses a comprehensive prevention and control technology of a corn waterlogging disaster, wherein soil ridging or compartment ridging regulation and control are utilized. The comprehensive prevention and control technology comprises the following steps: 
sowing in a wide and narrow row spacing manner during corn 
sowing, carrying out intertillage ridging or ditching during the five-leaf stage of corn, ditching in wide rows of corn and ridging in narrow rods of corn, or ditching in wide rows on the two sides of a compartment consisting of four or six rows, additionally applying 
nitrogen-
oxygen mixed 
fertilizer instantly after the corn waterlogging disaster occurs, and spraying 
spermidine chemical modifier on leaf surfaces at the same time, wherein spraying is carried out once in the 
morning and night for 2-3 days continuously; other steps are the same as that during normal management, corn is harvested until bracts of corn clusters are dried up, 
corn grain milk lines disappear, and a 
black layer appears, namely when grains are completely and physiologically matured. According to the comprehensive prevention and control technology, through comprehensive precontrol advantages of prevention in advance and remedy after the disaster, the root 
oxygen deficiency after waterlogging can be effectively reduced and retarded, accumulated toxic effect of hazardous substances of soil is reduced, and the 
root growth and 
absorption capacity is strengthened, so that the symplastic growth of overground part and 
root system is promoted, and the yield is improved.