Chitosan capsule shell and preparation method thereof

Abstract

The invention discloses a chitosan capsule shell and a preparation method thereof. The chitosan capsule shell is mainly made of, by weight, 10%-12% of chitosan, 1% of acetic acid and 87%-89% of water. The preparation method includes the steps of firstly, preparing; secondly, dissolving; thirdly, molding; fourthly, demolding and cutting after drying; and fifthly, nesting capsules and capsule caps after cutting, and separating and finally inspecting to obtain chitosan capsule shells. The capsule shells are mainly made of the chitosan, temperature resistance, elasticity and dissolution rate of the capsule shells are determined on physical properties of the chitosan, and accordingly the defect of high requirements of gelatin capsule shells on water content and storage environment is overcome. The chitosan capsule shells made by the preparation method according to a formula completely meet eating requirements of drugs and foods. In addition, the chitosan has good physiological activity and is beneficial to human bodies, and safety of the chitosan capsule shells is higher than that of animal derived gelatin capsule shells evidently.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a chitosan capsule shell and a preparation method thereof. Background technique [0002] The capsule shell is used to contain solid powder and granular pharmaceutical preparations, which solves the problems of difficult to drink and poor taste of medicines for users, and makes good medicines no longer taste bitter. Since the capsule shell enters the digestive system of the human body together with the medicine or health food preparation, its quality and safety performance are directly related to the quality and safety performance of the medicine and health food. [0003] At present, the most common capsule shell is made of food-grade medicinal gelatin and auxiliary materials through refined treatment, while the medicinal gelatin is mostly made of pig or cow skin and bone. This kind of capsule shell prepared from animal sources is subject to many restrictions in use, such as: 1....

AI Technical Summary

Problems solved by technology

This kind of capsule shell prepared from animal sources is subject to many restrictions in use, such as: 1. Too little water content is easy to break, and too much water content is easy to soften and deform. Therefore, the water content is very strict and should be controlled at 12.5-17.5%. Among them, this characteristic is not conducive to the filling of drugs, especially when filling some drugs containing hygroscopic ingredients, the moisture in the capsule shell has been absorbed by the filling, making the capsule preparations easy to crack and break during storage, affecting Product quality; 2. The storage conditions are strict, and should not be stored under high temperature and high humidity conditions, otherwise it will become sticky and deformed due to heat softening, and should not be placed in an environment with too low temperature or too dry, otherwise the capsule shell will prone to brittleness