Unlock instant, AI-driven research and patent intelligence for your innovation.

Trans-tranexamic acid purifying method

A technology of trans tranexamic acid and trans cis tranexamic acid, which is applied in the field of medicine, can solve the problems of low tranexamic acid content, and achieve the effects of simple operation, improved purity and low cost

Inactive Publication Date: 2012-10-03
YANGZHOU TIANHE PHARM CO LTD
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing production process of tranexamic acid, the cis isomer cannot be completely converted into trans tranexamic acid, and the current purification process of tranexamic acid in the same industry is mainly from the trans cis tranexamic acid mixture The alcohol washing method is used, the content of tranexamic acid obtained is low, and it needs to be refined many times

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Trans-tranexamic acid purifying method
  • Trans-tranexamic acid purifying method
  • Trans-tranexamic acid purifying method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Throw 50g of cis-trans tranexamic acid mixture (among them, the mass ratio of cis-trans is 25:75) into 150g of purified water, stir and heat up to 70°C, keep warm for 30min, cool to 2°C with ice-salt bath, filter, and get damp 55g of the product, and the filtrate was recovered; the obtained tidal product was put into 165g of purified water, heated and stirred, when the temperature rose to 75°C, the solution was dissolved, and sulfuric acid was added to adjust the pH to 6, and 2g of activated carbon was added for decolorization and kept for 30min, filtered, and the filtrate was cooled to -10°C, filter, apply the filtrate mechanically, and dry the obtained solid at a temperature of 95 to 105°C to obtain 25 g of trans-tranexamic acid with a yield of 50%, wherein the content of cis-tranexamic acid is 0.05%, and the product purity is 99.8%.

Embodiment 2

[0027] Throw 50g of cis-trans tranexamic acid mixture (cis:trans = 25:75) into 100g of purified water, stir and heat up to 75°C, keep warm for 30min, cool to -5°C with ice-salt bath, filter to obtain 62g of damp product, Filtrate recovery; put the obtained tidal product into 250g of purified water, heat up and stir, when the temperature rises to 65°C, the solution dissolves, add sulfuric acid to adjust the pH to 6.5, add 2g of activated carbon to decolorize and keep it warm for 30min, filter, and cool the filtrate to -5°C , filtered, and the filtrate was used mechanically, and the obtained solid was dried at a temperature of 95-105° C. to obtain 22 g of trans-tranexamic acid, with a yield of 44%, wherein the content of cis-tranexamic acid was 0.03%, and the product purity was 99.6%.

Embodiment 3

[0029] Throw 50g of cis-trans tranexamic acid mixture (cis:trans = 20:80) into 100g of the mother liquor, stir and heat up to 85°C, keep warm for 30min, cool to -5°C in an ice-salt bath, filter to obtain 65g of damp product , filtrate recovery; put the obtained tidal product into 280g purified water, heat up and stir, when the temperature rises to 65°C, the solution dissolves, add sulfuric acid to adjust the pH to 7.5, add 2g of activated carbon for decolorization and heat preservation for 30min, filter, and cool the filtrate to -10 ℃, filtered, and the filtrate was applied mechanically, and the obtained solid was dried at a temperature of 95-105°C to obtain 35 g of trans-tranexamic acid, with a yield of 70%, of which the content of cis-tranexamic acid was 0.08%, and the product purity was 99.4% .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a trans-tranexamic acid purifying method, belongs to the technical field of medicine and particularly relates to a separation and purification method of a substance. The trans-tranexamic acid purifying method comprises the following steps: firstly, mixing a mixture of trans-tranexamic acid and cis-tranexamic acid with purified water, and heating to form an aqueous solution of the trans-tranexamic acid and the cis-tranexamic acid; secondly, cooling and filtering the aqueous solution of the trans-tranexamic acid and the cis-tranexamic acid to obtain a damp tranexamic acid mixture; and finally, mixing the damp tranexamic acid mixture with purified water, heating, regulating the pH value, adding active carbon, filtering, cooling and crystallizing a filtrate, filtering, drying a solid to obtain white crystals of the trans-tranexamic acid. According to the trans-tranexamic acid purifying method, the purity of the obtained trans-tranexamic acid is greatly improved and the trans-tranexamic acid with the purity of not less than 99% can be obtained; a solvent can be recycled; and the trans-tranexamic acid purifying method is simple in operation, low in pollution and low in cost and is applicable to industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a method for separating and purifying substances. Background technique [0002] Tranexamic acid, chemical name: 4-aminomethylcyclohexanecarboxylic acid, alias: tranexamic acid; English name: Tranexamic Acid, molecular formula: C 8 h 15 NO 2 ; The structural formula is as follows: [0003] [0004] Molecular weight: 157.21. Pure tranexamic acid is white crystalline powder, odorless, slightly bitter taste; easily soluble in water, almost insoluble in ethanol, acetone, and chloroform. Tranexamic acid is mainly used in hemostatic drugs and daily chemical products. [0005] In the existing production process of tranexamic acid, the cis isomer cannot be completely converted into trans tranexamic acid, and the current purification process of tranexamic acid in the same industry is mainly from the trans cis tranexamic acid mixture What adopted was the alcohol flushing metho...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C229/46C07C227/34
Inventor 赵云德庄伟东
Owner YANGZHOU TIANHE PHARM CO LTD