Therapeutic or prophylactic agent for biliary diseases
A technology for preventing medicines and diseases, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients to achieve significant therapeutic or preventive effects.
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[0108] Example 1 (-)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamide ]Effect of morphinane hydrochloride (compound 1) on contraction of rabbit sphincter of Oddi
[0109] The method described in Wei JG et al., World J. Gastroenterol., 6, 102 (2000) was partially modified to measure changes in the perfusion resistance pressure of the sphincter of Oddi. It should be noted that the changes in the perfusion resistance pressure of the sphincter of Oddi reflect the contraction of the sphincter of Oddi.
[0110] NZW male rabbits (Japan SLC) with a body weight of 2.0 to 2.5 kg upon arrival were used, and fasting was started from the evening of the day before the experiment. The experiment was carried out under pentobarbital anesthesia and artificial ventilation. The rabbit was fixed in the dorsal position, after which the abdomen was incised to expose the periduodenum and common bile duct. The common bile duct was cut slightly, and the ca...
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