Application of glycine to preparation of medicine for treating AD (alzheimer diseases)

A technology for Alzheimer's disease and glycine, applied in the field of glycine, can solve problems such as lack of effective drugs for treatment, achieve significant prevention and treatment effects, and improve memory function.

Inactive Publication Date: 2012-10-10
韩德五
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the pathogenesis of AD is not yet fully understo...

Method used

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  • Application of glycine to preparation of medicine for treating AD (alzheimer diseases)
  • Application of glycine to preparation of medicine for treating AD (alzheimer diseases)
  • Application of glycine to preparation of medicine for treating AD (alzheimer diseases)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1: Effect of glycine on AD rats induced by high fructose.

[0009] Experimental method: 24 rats were randomly divided into control group, high fructose group and glycine group, with 8 rats in each group. The control group was fed with tap water; the high fructose group was fed with 8% fructose water; the glycine group was fed with 8% fructose water and 1% glycine at the same time, and the rats in the above groups were free to eat (standard large rat feed). After 8 months of administration, the Morris water maze experiment was carried out to each group of rats. The Morris water maze was a study designed and applied to the brain learning and memory mechanism by the British psychologist Morris in the 1980s (1981). It is commonly used in research to test the memory function of animals. The Morris water maze test mainly consists of a place navigation test. This test lasted for 5 days. Rats were put into the water from 4 water entry points facing the pool wall sever...

Embodiment 2

[0017] Embodiment 2: Glycine to galactose+AlCl 3 Effects of Induced AD Rats.

[0018] Experimental method: 30 rats were randomly divided into control group, galactose group and glycine group, with 10 rats in each group. The control group ate normally, and the galactose group was intraperitoneally injected with D-galactose (60 mg·kg -1 d -1 )+AlCl 3 (25mg·kg -1 d -1 ), the glycine group received intraperitoneal injection of D-galactose (60 mg·kg -1 d -1 )+AlCl 3 (25mg·kg -1 d -1 ) at the same time oral glycine (5 mg·g -1 d -1 ), the above rats were free to eat (tap water and standard rat chow). After 3 months, the Morris water maze test and other related AD indicators were tested on the rats in each group.

[0019] Experimental results: as shown in Table 3 below, compared with the control group, the memory function of the rats in the galactose group was severely impaired ( P P 0.05); indicating that glycine can improve memory function.

[0020] Table 3 The re...

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PUM

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Abstract

The invention relates to a purpose of glycine, in particular to an application of glycine to the preparation of medicine for treating AD (alzheimer diseases), which solves the problem of lack of effective medicine for treating AD and provides medicine for effectively preventing and treating AD. AD mice with high-fructose diet or intraperitoneal galactose injection and AlCl3 induction are adopted for experiments, the damaged memory function of the mice can be effectively improved through the oral administration of the glycine, and the Abeta1-40 level in the brain, the number of age pigment and the abnormal phosphorylation expression of Tau protein are reduced. The results show that the glycine has the obvious prevention and treatment effect on AD and can be widely applied to the medicine for treating AD.

Description

technical field [0001] The invention relates to the use of glycine, in particular to the application of glycine as a medicine for treating Alzheimer's disease. Background technique [0002] The chemical name of Glycine is Aminoacetic Acid, and its molecular structure is: [0003] , [0004] Molecular formula is C 2 h 5 NO 2 , with a molecular weight of 75.07; its physical characteristics are white crystalline powder monoclinic or hexagonal crystals, odorless and sweet, and its solubility in water is 25g / 100ml (25°C). Glycine can be mixed with a variety of amino acids to make amino acid injections, which are used for patients with acute hypoalbuminemia before and after surgery, trauma, burns, fractures, and patients with acute hypoalbuminemia; used together with glutamic acid and alanine to treat complications of prostatic hypertrophy and urination disorders Patients (edited by Gao Zhuofeng, Practical Encyclopedia of Nutritional Medicine and Clinical Drugs, Beijing: Ch...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P25/28
Inventor 吴惠文贠克明韩柏韩德五
Owner 韩德五
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