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Oral magnesium hydroxide solid preparation

A magnesium hydroxide oral and solid preparation technology, applied in the digestive system, aluminum/calcium/magnesium active ingredients, powder delivery, etc., to achieve good effect, good taste and high bioavailability

Active Publication Date: 2014-04-23
JIANGSU WANBANG BIOPHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to make magnesium hydroxide into a solid preparation of dry suspension dosage form that can be easily taken orally by people with difficulty swallowing, such as the elderly and children.

Method used

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  • Oral magnesium hydroxide solid preparation
  • Oral magnesium hydroxide solid preparation
  • Oral magnesium hydroxide solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Magnesium hydroxide 800g

[0046] Sodium Carboxymethyl Cellulose 200g

[0047] Orange Flavor 50g

[0048] Sucrose 950g

[0049] Makes 1000 bags.

[0050] Its preparation method is

[0051] 1) Pre-treatment: crush the magnesium hydroxide through a 100-mesh sieve, and separately crush the suspending agent, fragrance and flavoring agent through a 100-mesh sieve for later use;

[0052] 2) Stirring and mixing: Weigh the above-mentioned raw and auxiliary materials in parts by weight according to the method of equal quantity addition, put them into a mixer and stir evenly, and the mixing time is 10 minutes;

[0053] 3) Sieve and mix: pass through a 100-mesh sieve and mix 3 times;

[0054] 4) Inspection-packaging: measure the particle content, check the appearance, sedimentation volume ratio of the dry suspension, and pack it after passing the inspection according to the quality standard requirements. Each bag contains 800mg of magnesium hydroxide.

Embodiment 2

[0056] Magnesium hydroxide 1200g

[0057] Sodium Carboxymethyl Cellulose 100g

[0058] Orange flavor 30g

[0059] Sucrose 670g

[0060] Makes 1000 bags.

[0061] The preparation method is the same as in Example 1. According to the relevant requirements of the Chinese Pharmacopoeia 2010 edition on the sedimentation volume ratio inspection of dry suspensions: add 10ml of water to the magnesium hydroxide dry suspensions prepared in this example, the preparation has good dispersibility, shake vigorously for 1min, then let stand for 3h, Results The sedimentation volume ratio F=0.98, which meets the requirements of Pharmacopoeia.

Embodiment 3

[0063] Magnesium hydroxide 1600g

[0064] Sodium Carboxymethyl Cellulose 20g

[0065] Orange flavor 10g

[0066] Sucrose 370g

[0067] Makes 1000 bags.

[0068] The preparation method is the same as in Example 1.

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Abstract

The present invention relates to a magnesium hydroxide preparations, and particularly to an oral magnesium hydroxide solid preparation. The purpose of the present invention is to solve the following technical problems that: the magnesium hydroxide is prepared into a dry suspension type sold preparation with good compliance, wherein oral taking of the sold preparation by dysphagia populations such as old man and children is convenient. Raw materials and assistant materials of the preparation of the present invention comprise the following components, by weight, 40-80 parts of magnesium hydroxide, 1-10 parts of an assistant suspending agent, 0.5-2.5 parts of a flavoring agent, and 18.5-47.5 parts of a correctant. The preparation method comprises: 1) carrying out a pre-treatment: the magnesium hydroxide is crushed and screened by a sieve with a mesh of 80-120, the assistant suspending agent, the flavoring agent and the correctant are separately crushed and screened by a sieve with a mesh of 80-120 to provide a spare use; 2) stirring and mixing; 3) screening and mixing; and 4) testing and packaging.

Description

technical field [0001] The invention relates to a magnesium hydroxide preparation, in particular to an oral solid preparation of magnesium hydroxide—dry suspension. Background technique [0002] Constipation is a group of symptomatic nouns, referring to a group of symptoms related to the disturbance of fecal excretion. In real life, constipation is the most common symptom of the digestive tract, but globally speaking, 5% to 25% of the population suffers from constipation. Epidemiological data show that the incidence rate in my country is about 10% to 15%. Elderly people over the age of 60 accounted for 18% to 23% of the population. The age of onset statistical table shows that the first peak appears at 30-39 years old. It suggested a younger trend in the age of onset. The male to female ratio is 1:4.59. If the chief complaint of difficult defecation is used as the evaluation standard of constipation, the incidence rate can be much higher than 50%. At present, the dosag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K33/06A61P1/10
Inventor 王建芳吴承龙香川恭一金一陈大为王成润
Owner JIANGSU WANBANG BIOPHARMLS
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