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Intrauterine sustained control release drug delivery system adopting biodegradation material, and preparation method thereof

A biodegradable material and drug delivery system technology, applied in the field of biodegradable material intrauterine slow and controlled release drug delivery system and its preparation, can solve problems such as uterine injury, copper woman injury, and unreasonable shape of drug delivery system, and achieve recovery Fertility function, prevention of bleeding, effect of high-efficiency contraceptive effect

Active Publication Date: 2012-10-24
杨立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, the intrauterine drug delivery system containing progesterone currently studied is either a stent structure, which will cause certain damage to the uterus of women; or an intrauterine drug delivery system containing copper, and the side effects of copper also cause certain damage to women. harm
The research on individual intrauterine drug delivery systems has progressed to the pre-clinical stage, but there is still a long way to go before practical applications, and there are problems with the unreasonable form of drug delivery systems

Method used

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  • Intrauterine sustained control release drug delivery system adopting biodegradation material, and preparation method thereof
  • Intrauterine sustained control release drug delivery system adopting biodegradation material, and preparation method thereof
  • Intrauterine sustained control release drug delivery system adopting biodegradation material, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] 1. Mix polycaprolactone and poloxamer (the particle size is 50 μ m, accounting for 3% of the total weight of the mixture), and extrude a pipe with an outer diameter of 3.0 mm and a wall thickness of 0.5 mm in a screw extruder to prepare a buffer Controlled release tubing, cut to 30mm. The extrusion temperature is 60°C, the screw speed is 15r / min, the traction speed is 20cm / min, the melt pump speed is 5r / min, the air flow rate is 7ml / min, and the molecular weight of polycaprolactone used is 2×10 4 g / mol.

[0061] 2. Set the molecular weight to 2×10 4 g / mol polycaprolactone and gestodene crystalline powder (mass ratio: 100:6) were stirred in a mixer at 70°C for 5 minutes to form a premix and then put into the mold of the molded rod, and the mold was placed in On a flat vulcanizer, preheat at 80°C for 2 minutes, then pressurize at 5Mpa for 1 minute, take it out, and cold press it for 2 minutes, and finally demould to obtain a gestodene-containing drug core with a diamete...

Embodiment 2

[0065] The difference from Example 1 is that the length of the drug core is changed to 30 mm, and the mass ratio of polycaprolactone to gestodene crystalline powder is 100:10, so that the effective length of the intrauterine drug delivery system is 24 mg / kg of gestodene. 30mm, the molecular weight of polycaprolactone used is 5.3×10 4 g / mol, the release amount is 30μg / d, and the service life is at least 2 years.

Embodiment 3

[0067] The difference from Example 1 is that the preparation method of the drug core containing gestodene is extrusion molding, and the molecular weight is 2×10 4 g / mol polycaprolactone and gestodene crystalline powder (mass ratio 100:6) were stirred in a mixer at 70°C for 5 minutes to form a premix, the screw speed was 20r / min, and the traction speed was 20cm / min, the melt pump speed is 5r / min, the air flow rate is 10ml / min, extrude a gestodene-containing drug core with a diameter of 1.8mm on the screw extruder.

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Abstract

The present invention relates to a female intrauterine drug delivery system, and more particularly to an intrauterine sustained control release drug delivery system adopting a biodegradation material, and a preparation method thereof. The present invention provides an intrauterine sustained control release drug delivery system adopting a biodegradation material, and a preparation method thereof, wherein the system has characteristics of short length, light weight, efficiency, and reversibility. The system comprises a sustained control release pipe, a drug core and a tail filament, wherein the sustained control release pipe is wrapped on the external of the drug core, the tail filament is positioned between the sustained control release pipe and the drug core or is accommodated in the middle of the drug core, the drug core is a rod prepared by blending progesterone or an available intrauterine sustained control release drug and a biodegradable polymer, and the sustained control release pipe is made of a biodegradable polymer. The system of the present invention has characteristics of no stent, no copper ion, safety, practicality, and simple placement technology.

Description

Technical field: [0001] The invention relates to an intrauterine drug delivery system for women, more specifically, an intrauterine sustained and controlled release drug delivery system of biodegradable materials and a preparation method thereof. Background technique: [0002] At present, the progesterone-containing intrauterine drug delivery system on the market is mainly Mirena, but it has a stent structure and causes certain damage to the uterus of women. Intrauterine drug delivery systems for the treatment of gynecological conditions also commonly come in the form of IUDs. Intrauterine Device (IUD) is a contraceptive device placed in the uterine cavity of a woman. It is a safe, effective, simple, economical and reversible birth control method. According to statistics from the World Health Organization in 2002, more than 156 million women in the world use IUDs, and their usage rate is on the rise. In my country, more than 100 million women use IUDs, accounting for about ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/57A61P15/00A61P35/00A61J3/00
Inventor 李建新杨立群杨丹关艳敏
Owner 杨立群
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