Application of Yinhua Miyanling Pian in preparation of drug for reversing drug resistance of escherichia coli
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A technology of Escherichia coli and Biyanling tablets, applied in the field of medicine, can solve the problems of prolonged clinical treatment time of infectious diseases and increased chances of infection recurrence
Inactive Publication Date: 2012-11-07
吉林华康药业股份有限公司
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[0005] The invention provides the application of Yinhua Miyanling Tablets in the preparation of drugs for reversing drug resistance, so as to solve the problems that antibacterial drugs induce the emergence of drug-resistant bacteria, increase the clinical treatment time of infectious diseases, and increase the chance of infection recurrence
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[0008] The present invention is further illustrated below by experiment.
[0009] 1. Materials and methods
[0010] 1.1 Materials
[0011] 1.1.1 Source of the strain: Escherichia coli ATCC 25922 was from the Laboratory of Pathogenic Microbiology, Jilin University.
[0017] Nutrient Agar (Batch No.: 20111202), M-H Broth Medium (Batch No.: 20111125), Easy Taq DNA polymerase, High Pure dNTPs, Easy Taq 10×Buffer (TRAAS) , PCR Purification Kit (QIAGEN, Ge...
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Abstract
The invention relates to application of Yinhua Miyanling Pian in preparation of a drug for reversing drug resistance of escherichia coli, belonging to the field of a drug. The Yinhua Miyanling Pian is applied to preparing the drug for inducing the drug resistance of escherichia coli under the pressure of levofloxacin. The bacteria passaged by a drug combination group of the Yinhua Miyanling Pian and the levofloxacin can not generate mutation of parC genes, which shows that the Yinhua Miyanling Pian is capable of reversing the drug resistance of the bacteria caused by antibiotics.
Description
technical field [0001] The invention belongs to the field of medicine, in particular to the new medicinal use of Yinhua Biyanling Tablets. Background technique [0002] Yinhua Biyanling Tablets, National Drug Standard WS3-526(Z-107)-2003(Z). [0003] Prescription, honeysuckle, Scutellaria barbata, flat storage, Qumai, Shiwei, Akebia, plantain seed, light bamboo leaves, mulberry, rush. This product is a light green sugar-coated tablet. After removing the sugar-coating, the tablet core is dark brown. The taste is slightly bitter and astringent. Functions and indications, clearing away heat and detoxification, promoting dampness and treating stranguria, used for acute pyelonephritis, acute cystitis, syndrome of damp-heat in lower jiao, fever and chills, frequent urination, urethral tingling or hematuria, low back pain, etc. Oral, 8 tablets at a time, 4 times a day, two weeks as a course of treatment, can be taken for three courses, or follow the doctor's advice. [0004] Inf...
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