Method for producing ultra-low-acid ginkgo leaf extract

A production method and ginkgo leaf technology are applied in the field of extraction and separation of effective components of natural plants, can solve problems such as difficulty in reaching ultra-low acid specifications of ginkgolic acid, and achieve the effects of low production cost, simple process and safe production process

Inactive Publication Date: 2012-11-14
TIANJIN TAIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem that the existing ginkgo leaf extract preparation method is difficult to reach the ultra-l

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] Example 1

[0040] Take 100kg of Ginkgo biloba leaves into the extraction kettle, add 600L of ethanol with a volume concentration of 80%, stir and extract at 70°C for 3h, drain the solution, then add 500L of 80% ethanol to the extraction kettle, stir and extract at 70°C for 2h, Dispensing.

[0041] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 400L, allowed to stand for 12h, and filtered to obtain a clear solution.

[0042] 100L ME-1 macroporous adsorption resin (Tianjin Orui Biological Co., Ltd.) on the Qingye, control the flow rate of 100L / h, after the adsorption is completed, rinse 200L with pure water, and the flow rate is 100L / h.

[0043] After rinsing, use 300L of ethanol with a volume concentration of 70% to desorb, and the desorbed solution directly passes through 100L of MG-2 gel-type hydrogen bond adsorption resin (Tianjin Ou Rui Biological Co., Ltd.), with a flow rate of 100L / h, and an appropriate volume...

Example Embodiment

[0044] Example 2

[0045] Take 100kg of Ginkgo biloba leaves into the extraction kettle, add 700L of ethanol with a volume concentration of 83%, stir and extract at 70°C for 3h, then let the solution, then add 600L of 83% ethanol to the extraction kettle, stir and extract at 70°C for 2h, Dispensing.

[0046] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 350L, allowed to stand for 18h, and filtered to obtain a clear solution.

[0047] 200LADS-17 macroporous adsorption resin (commonly available on the market) on Qingye, with a controlled flow rate of 100L / h, after the adsorption is completed, rinse with 100L of pure water at a flow rate of 100L / h.

[0048] After rinsing, use 300L of ethanol with a volume concentration of 65% to desorb. The desorbed solution is directly passed through 100L of MG-1 gel-type hydrogen bond adsorption resin (Tianjin Orui Biological Co., Ltd.). The flow rate is controlled to 100L / h, and the appro...

Example Embodiment

[0049] Example 3

[0050] Take 800kg of Ginkgo biloba leaves into the extraction kettle, add 5600L of ethanol with a volume concentration of 80%, stir and extract at 70°C for 3h, drain, and then add 4800L of 80% ethanol to the extraction kettle, stir and extract at 70°C for 2h, Dispensing.

[0051] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 2400L, allowed to stand for 12h, and centrifuged to obtain a clear solution.

[0052] 1000L AB-8 macroporous adsorption resin (commonly available in the market) on the Qingye, control the flow rate of 1000L / h, after the adsorption is completed, rinse 2000L with pure water at a flow rate of 1000L / h.

[0053] After rinsing, use 3500L of ethanol with a volume concentration of 70% to desorb. The desorbed solution is directly passed through 1000L of MG-2 gel hydrogen bond adsorption resin (Tianjin Ou Rui Biological Co., Ltd.). The flow rate is controlled to 1000L / h, and the appropriate v...

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Abstract

The invention discloses a method for producing an ultra-low-acid ginkgo leaf extract. According to the method, ginkgo leaves or extracts of the common ginkgo leaves are used as raw materials; the ginkgolic acid content in the produced ginkgo leaf extract is less than 1 ppm. The ginkgo leaves are used as the raw materials, and the method comprises the following steps of: extracting by an organic solvent aqueous solution; concentrating an extracted solution, and recycling a solvent; adding water to dilute the solution, standing and sedimentating; centrifugating or filtering to eliminate sedimentations; adsorbing the supernate by large-hole resin; washing by water to remove impurities; desorbing the organic solvent aqueous solution, directly deacidifying gel type hydrogen-bonding adsorbent resin, and washing; and concentrating and drying the flow-out solution and the washed solution to obtain the ultra-low-acid ginkgo leaf extract. The extracts of the common ginkgo leaves are used as the raw materials, and the method comprises the following steps of: dissolving the organic solvent aqueous solution, directly removing ginkgolic acid through the gel type hydrogen-bonding adsorbent resin, washing, and concentrating and drying the flow-out solution and the washed solution to obtain the ultra-low-acid ginkgo leaf extract. According to the method, the process is simple and reliable; the production cost is low; in the production process, toxic organic solvents are not used; and the production process is safe and environment-friendly.

Description

technical field [0001] The invention relates to a production method of an ultra-low-acid ginkgo leaf extract, and belongs to the technical field of extraction and separation of active ingredients of natural plants. Background technique [0002] Ginkgo biloba (Ginkgo biloba L.) is an important medicinal plant. Ginkgo biloba is the leaf of Ginkgo biloba. value. In the 1970s, Germany took the lead in formulating quality standards for ginkgo extract (GBE), that is, standard ginkgo extract (total flavonol glycosides ≥ 24%, terpene lactone ≥ 6%, ginkgolic acid ≤ 10ppm), the standard Furthermore, it has become the general international standard for Ginkgo biloba extract. At present, Ginkgo biloba extract has been made into various preparations, which are widely used in the treatment of cardiovascular and cerebrovascular diseases. The main active ingredients of Ginkgo biloba extract are flavonol glycosides and terpene lactones. Natural Ginkgo biloba contains a large amount of gin...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/00A61K127/00
Inventor 欧来良王为超张华李红艳
Owner TIANJIN TAIYANG PHARMA
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