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Method for producing ultra-low-acid ginkgo leaf extract

A production method and ginkgo leaf technology are applied in the field of extraction and separation of effective components of natural plants, can solve problems such as difficulty in reaching ultra-low acid specifications of ginkgolic acid, and achieve the effects of low production cost, simple process and safe production process

Inactive Publication Date: 2012-11-14
TIANJIN TAIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem that the existing ginkgo leaf extract preparation method is difficult to reach the ultra-low acid specification of ginkgolic acid <1ppm, and to provide a simple, effective and suitable for the production of ultra-low acid ginkgo leaf extract method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Get 100kg Ginkgo biloba and add in the extraction kettle, add volumetric concentration and be 80% ethanol 600L, stir and extract 3h at 70°C, drain, then add 80% ethanol 500L in the extraction kettle, stir and extract at 70°C for 2h, Drain.

[0041] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 400L, allowed to stand for 12 hours, and filtered to obtain a clear solution.

[0042] Put 100L ME-1 macroporous adsorption resin (Tianjin Orui Biological Co., Ltd.) in the clear and control the flow rate of 100L / h. After the adsorption is completed, rinse 200L with pure water at a flow rate of 100L / h.

[0043] After washing, use 300L ethanol with a volume concentration of 70% for desorption, and the desorption solution directly passes through 100L MG-2 gel-type hydrogen bond adsorption resin (Tianjin Orui Biological Co., Ltd.), control the flow rate at 100L / h, and use an appropriate volume concentration of 70% % ethan...

Embodiment 2

[0045] Get 100kg Ginkgo biloba and add in the extraction kettle, add the ethanol 700L that volume concentration is 83%, stir and extract 3h at 70 DEG C, drain, then add 83% ethanol 600L in the extraction kettle, stir and extract at 70 DEG C for 2h, Drain.

[0046] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 350L, allowed to stand for 18 hours, and filtered to obtain a clear solution.

[0047] Put 200LADS-17 macroporous adsorption resin (generally available in the market) in the clear night, control the flow rate of 100L / h, rinse 100L with pure water after the adsorption is completed, and the flow rate is 100L / h.

[0048] After washing, use 300L ethanol with a volume concentration of 65% for desorption, and the desorption solution directly passes through 100L MG-1 gel-type hydrogen bond adsorption resin (Tianjin Orui Biological Co., Ltd.), control the flow rate at 100L / h, and use an appropriate volume concentrati...

Embodiment 3

[0050] Get 800kg Ginkgo biloba and add in the extraction kettle, add volume concentration and be 80% ethanol 5600L, stir and extract 3h at 70°C, drain, then add 80% ethanol 4800L in the extraction kettle, stir and extract at 70°C for 2h, Drain.

[0051] The two extracts were combined, concentrated under reduced pressure to recover ethanol, diluted with water to 2400L, allowed to stand for 12 hours, and centrifuged to obtain a clear solution.

[0052] Put 1000L AB-8 macroporous adsorption resin (commercially available) in the clear night, control the flow rate of 1000L / h, rinse 2000L with pure water after the adsorption is completed, and the flow rate is 1000L / h.

[0053] After washing, use 3500L ethanol with a volume concentration of 70% for desorption, and the desorption solution directly passes through 1000L MG-2 gel-type hydrogen bond adsorption resin (Tianjin Orui Biological Co., Ltd.), control the flow rate at 1000L / h, and use an appropriate volume concentration of 70% %...

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Abstract

The invention discloses a method for producing an ultra-low-acid ginkgo leaf extract. According to the method, ginkgo leaves or extracts of the common ginkgo leaves are used as raw materials; the ginkgolic acid content in the produced ginkgo leaf extract is less than 1 ppm. The ginkgo leaves are used as the raw materials, and the method comprises the following steps of: extracting by an organic solvent aqueous solution; concentrating an extracted solution, and recycling a solvent; adding water to dilute the solution, standing and sedimentating; centrifugating or filtering to eliminate sedimentations; adsorbing the supernate by large-hole resin; washing by water to remove impurities; desorbing the organic solvent aqueous solution, directly deacidifying gel type hydrogen-bonding adsorbent resin, and washing; and concentrating and drying the flow-out solution and the washed solution to obtain the ultra-low-acid ginkgo leaf extract. The extracts of the common ginkgo leaves are used as the raw materials, and the method comprises the following steps of: dissolving the organic solvent aqueous solution, directly removing ginkgolic acid through the gel type hydrogen-bonding adsorbent resin, washing, and concentrating and drying the flow-out solution and the washed solution to obtain the ultra-low-acid ginkgo leaf extract. According to the method, the process is simple and reliable; the production cost is low; in the production process, toxic organic solvents are not used; and the production process is safe and environment-friendly.

Description

technical field [0001] The invention relates to a production method of an ultra-low-acid ginkgo leaf extract, and belongs to the technical field of extraction and separation of active ingredients of natural plants. Background technique [0002] Ginkgo biloba (Ginkgo biloba L.) is an important medicinal plant. Ginkgo biloba is the leaf of Ginkgo biloba. value. In the 1970s, Germany took the lead in formulating quality standards for ginkgo extract (GBE), that is, standard ginkgo extract (total flavonol glycosides ≥ 24%, terpene lactone ≥ 6%, ginkgolic acid ≤ 10ppm), the standard Furthermore, it has become the general international standard for Ginkgo biloba extract. At present, Ginkgo biloba extract has been made into various preparations, which are widely used in the treatment of cardiovascular and cerebrovascular diseases. The main active ingredients of Ginkgo biloba extract are flavonol glycosides and terpene lactones. Natural Ginkgo biloba contains a large amount of gin...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/00A61K127/00
Inventor 欧来良王为超张华李红艳
Owner TIANJIN TAIYANG PHARMA
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