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Application of chrysanthemum extract

A kind of chrysanthemum extract and chrysanthemum technology, applied in the fields of application, medical preparations containing active ingredients, food science, etc., can solve the problems that there are no research reports on chrysanthemum and its extract

Inactive Publication Date: 2012-11-14
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no relevant research reports on the prevention and treatment of fatty liver by chrysanthemum and its extracts.

Method used

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  • Application of chrysanthemum extract
  • Application of chrysanthemum extract

Examples

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Effect test

Embodiment 1

[0014] In order to further understand the present invention, the present invention will be described in detail below in conjunction with examples. Embodiment 1: the preparation of chrysanthemum extract

[0015] Chrysanthemum medicinal material 2kg, reflux extraction with 70% ethanol for 2 times, 1.5 hours each time, combine the extracts, concentrate under reduced pressure to 0.5L, add water to 2L, filter, put the filtrate on the treated AB-8 resin column, Gradient elution was carried out with water, 10% ethanol, and 70% ethanol respectively with 3 BV, and the 70% ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain 68.4 g of chrysanthemum extract, with a yield of 3.42%.

[0016] Determination of index components in chrysanthemum extract by HPLC: Luteolin, chlorogenic acid, and 3,5-O-dicaffeoylquinic acid were used as reference substances, and the determination was carried out with reference to the method under the chrysanthemum item in Part 1 ...

Embodiment 2

[0017] Example 2: Effects of chrysanthemum extract on various indicators in mouse blood and liver tissue

[0018] 1. Tested drug: the chrysanthemum extract prepared in Example 1, before use, was formulated with 0.5% sodium carboxymethyl cellulose solution to a concentration of 0.375%, 0.75% and 1.5% respectively; comparison test preparation Lipin (not Nobel Capsules), produced by Liboforni Pharmaceutical Co., Ltd. in France, when used immediately, use 0.5% carboxymethylcellulose sodium solution to prepare 0.2% drug concentration respectively.

[0019] 2. Experimental animals: Kunming mice, male, weighing 22-24 grams, supplied by Shanghai Slack Experimental Animal Co., Ltd., clean grade, experimental animal production license number: SCXK (Shanghai) 2007-0005, used as experimental animals License: SYXK (SU) 2007-0035.

[0020] 3. Test method: Divide mice into 6 groups at random, which are normal control group, fatty liver model group, low-dose chrysanthemum extract group (75mg...

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Abstract

The invention relates to the technical field of healthcare food and medicine, and discloses new application of chrysanthemum extract. In the invention, the influence of the chrysanthemum extract on the blood fat and liver fat of mice is detected by detecting the influence of the chrysanthemum extract on the TC, TG and HDL-C content and liver weight coefficient in mouse blood and on the TC, TG, SOD and MDA content in the mouse liver tissue. The result indicates that the chrysanthemum extract has an effect of reducing blood fat as well as liver fat. Thus, the invention provides application of the chrysanthemum extract in preparing healthcare food and medicine for preventing and treating fatty liver.

Description

technical field [0001] The invention belongs to the technical field of health food and medicine, relates to the application of chrysanthemum extract, and further relates to the application of chrysanthemum extract in preparing health food and medicine for preventing and treating fatty liver. Background technique [0002] Fatty liver refers to the pathological changes caused by excessive accumulation of lipids in liver cells due to various reasons. Normal liver lipid accounts for 3%-4% of the liver weight. If the lipid content exceeds 5% of the liver weight, it is fatty liver. In severe cases, the lipid content can reach 40%-50%. With the improvement of people's living standards and the arbitrariness of lifestyles, the phenomenon of eating big fish and meat, unrestrained night meals, busy work, too much money, and less exercise is becoming more and more serious, and the incidence and number of fatty liver diseases have increased significantly. In recent years, the incidence ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P3/06A61P1/16A23L1/29A23L1/30A23L33/00
Inventor 谢梅林刘江云崔艳薛洁
Owner SUZHOU UNIV
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