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Method for producing pharmaceutical dimeticone

A production method and technology of simethicone, which is applied in the production field of pharmaceutical simethicone, can solve the problems of excessive phenyl compounds, excessive water content, low relative density, etc., and achieve high activity, low production cost and high production efficiency high effect

Inactive Publication Date: 2012-11-21
自贡鸿鹤化工股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a production method of pharmaceutical simethicone, which uses octamethylcyclotetrasiloxane (D4) and hexamethyldisiloxane as raw materials and a large-pore strong acid cation exchange resin as a catalyst The production of medicinal simethicone has solved the main quality problems such as excessive phenyl compounds in simethicone, low viscosity, low relative density, and excessive water content. Relevant standard requirements of the 2010 edition of "Chinese Pharmacopoeia"

Method used

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  • Method for producing pharmaceutical dimeticone

Examples

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Effect test

Embodiment 1

[0033] (1) Dehydrate the catalyst-LDX-604 type large pore size strong acid cation exchange resin (purchased from Jiangsu Nantong Taihelai Chemical Co., Ltd.), and vacuum dry it at 80 °C until nearly anhydrous, and the vacuum degree is ≤-0.06MP a , stored at low temperature (<-8℃) for later use.

[0034] (2) Add 300g of octamethylcyclotetrasiloxane and 15g of hexamethyldisiloxane after filtering into the mixing tank, stir and mix for 10 minutes, then put the mixed material into the measuring tank, and put it in the measuring tank. The mixture was heated to 90°C.

[0035] (3) with N 2 The mixture in the metering tank is pressed into the catalytic reactor containing 55g of LDX-604 type large-pore strong acid cation exchange resin pretreated in step 1). The temperature of the mixed material was at 90°C, and a positive displacement pump was used to circulate the material in the catalytic reactor for 1.5 hours. After the reaction, crude simethicone was obtained.

[0036] (4) wit...

Embodiment 2

[0038] (1) Dehydrate the catalyst-732 type strong acid styrene cation exchange resin (purchased from Wenxian Kaibiyuan Water Purification Material Factory), and vacuum dry it at 85°C until nearly anhydrous, with a vacuum degree of ≤-0.06MP a , stored at low temperature (<-8℃) for later use.

[0039](1) Add 320Kg of octamethylcyclotetrasiloxane and 10Kg of hexamethyldisiloxane after filtration into the mixing tank, stir and mix for 15 minutes, then put the mixed material into the measuring tank, and put it in the measuring tank. The mixture was heated to 92.5°C.

[0040] (2) with N 2 The mixture in the metering tank is pressed into the catalytic reactor containing the 62Kg 732 type strongly acidic styrene cation exchange resin pretreated in step 1), and the volume coefficient of the catalyst filling is 32%. The temperature was 95°C, and a positive displacement pump was used to circulate the material in the catalytic reactor for 1.25 hours. After the reaction, crude simethico...

Embodiment 3

[0043] (1) Dehydrate the catalyst-D001 type large pore size strong acid styrene cation exchange resin (purchased from Shanghai Kaiping Resin Co., Ltd.), and vacuum dry it at 90°C until nearly anhydrous, and the vacuum degree is ≤-0.06MP a , stored at low temperature (<-8℃) for later use.

[0044] (2) Add 321Kg of octamethylcyclotetrasiloxane and 12Kg of hexamethyldisiloxane after filtration into the mixing tank, stir and mix for 20 minutes, then put the mixed material into the measuring tank, and put it in the measuring tank. The mixture was heated to 95°C.

[0045] (3) with N 2 The mixture in the metering tank is pressed into the catalytic reactor containing the 70Kg D001-200 type large-pore strong acid styrene cation exchange resin pretreated in step 1, the volume coefficient of the catalyst filling is 35%, and the volume coefficient in the catalytic reactor is controlled. The temperature of the mixed material was 100°C, and a positive displacement pump was used to make th...

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Abstract

The invention discloses a method for producing pharmaceutical dimeticone. The method comprises steps of stirring and mixing a mixture of octamethyl cyclotetrasiloxane and hexamethyl disiloxane completely in accordance with the mass ratio of (6-7) : (0.12-0.5), then placing the mixture to a gauge tank and heating the mixture in the gauge tank to a temperature of 90 DEG C to 95 DEG C; pressing the mixture to a catalytic reactor which contains a catalyst, subjecting the mixture to a circular reaction for 1-1.5 hours at the reaction temperature of 90 DEG C to 100 DEG C and obtaining crude dimeticone; pressing the crude dimeticone to a refined distillation still, heating the distillation still to a temperature of 190 DEG C to 230 DEG C, controlling the vacuum to be no more than -0.09 MPa, desorbing oligomer and low-boiling-point substances, conducting a refining operation for 4-6 hours, transferring materials to a cooling reactor after indexes of materials inside the distillation still, such as flash points, are qualified through a sampling test, cooling materials to be below 50 DEG C, performing pressure filtration and obtaining the pharmaceutical dimeticone. Quality indexes of the pharmaceutical dimeticone meet standards of 2010 version Chinese pharmacopoeia, the production cost is low and the economic benefit is obvious.

Description

technical field [0001] The invention relates to a preparation method of dimethicone, in particular to a production method of medicinal dimethicone. Background technique [0002] Medicinal simethicone is the raw material drug, which has antifoaming effect and can be made into oral gastrointestinal defoaming tablets and pulmonary edema defoaming aerosols and other drugs. Adding simethicone to the ointment can improve the penetration ability of the drug into the skin, improve the efficacy of the drug, and also have a good effect on scalds, dermatitis, and bedsores. In addition, using the anticoagulant effect of simethicone to treat the surface of the blood reservoir can prolong the storage time of blood samples. The addition of dimethicone to cosmetics can improve skin moisturization and protection. [0003] At present, most of the industrial grade dimethicone is produced by the alkali method or the acid method, but the production technology method of producing industrial gra...

Claims

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Application Information

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IPC IPC(8): C08G77/08
Inventor 杨小川张沱江宋明陈坤
Owner 自贡鸿鹤化工股份有限公司
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