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Oil and fat composition for prevention or treatment of diabetes

An oil composition, diabetes technology, applied in the directions of drug combination, application, food science, etc., can solve problems such as edema, weight gain, rash, etc., and achieve the effect of continuous taking, high safety, and improvement of insulin resistance

Active Publication Date: 2014-09-03
THE NISSHIN OILLIO GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, taking SU agents can cause side effects such as hypoglycemia, itching, rash, weight gain, and pancreatic β-cell failure.
In addition, patients with liver disease and renal insufficiency are prohibited from taking thiazolidine drugs, which can cause side effects such as edema and weight gain

Method used

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  • Oil and fat composition for prevention or treatment of diabetes
  • Oil and fat composition for prevention or treatment of diabetes
  • Oil and fat composition for prevention or treatment of diabetes

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0045] Manufacturing method of sample 1

[0046] In 10 ml of 40% glucose (D(+)-Glucose, manufactured by Wako Pure Pharmaceutical Co., Ltd.), 2 g of LCT (trade name: Nissin Canoichira Oil, manufactured by Nissin Oyrio Group Co., Ltd.) and 200 mg of bovine serum albumin ( (manufactured by SIGMA Corporation), and the obtained solution was subjected to ultrasonic treatment while cooling on ice (5 minutes for two groups, 10 minutes in total), and Sample 1 was obtained. Table 1 shows the fatty acid composition of control LCT (trade name: Nissin Canoira Oil, manufactured by Nissin Oilio Group Co., Ltd.).

[0047] 【Table 1】

[0048]

manufacture example 2

[0049] Manufacturing method of sample 2

[0050] MCT (trade name: O.D.O, structural fatty acid: n-octanoic acid / n-capric acid=3 / 1, manufactured by Nissin Oyrio Group Co., Ltd.) and LCT (trade name: Nissin Oylio Group Co., Ltd. ) mixed in the ratio of 14:86 (mass ratio) to obtain mixed oil. After adding 0.1% by mass of lipase powder to the obtained mixed oil, the mixture was stirred at a temperature of 60° C. for 15 hours to perform a transesterification reaction. Next, lipase powder was filtered off from the reaction product, and the filtrate was washed with water, dried, and then decolorized and deodorized to obtain a transesterified oil of MCT and LCT (MLCT (1)). Then, to 10 ml of 40% glucose (D(+)-Glucose, manufactured by Wako Junpharmaceuticals Co., Ltd.), 2 g of the above-mentioned MLCT (1) (trade name: Nissin Canoichira Oil, manufactured by Nissin Oilio Group Co., Ltd.) was added. and 200 mg of bovine serum albumin (manufactured by SIGMA), and the resulting solution w...

manufacture example 3

[0066] Manufacturing method of sample 3

[0067] MCT (trade name: スコレ-64G, structural fatty acid: n-octanoic acid / n-capric acid=3 / 2, manufactured by Nissin Oyrio Group) and LCT (trade name: Nissin Corn Oil, Nissin Oyrio Group) Co., Ltd.) were mixed at a ratio of 30:70 (mass ratio) to obtain a mixed oil. The obtained mixed oil was subjected to transesterification, decolorization, and deodorization in the same manner as in Production Example 2 to obtain a transesterified oil of MCT and LCT (MLCT (2)). Then, to 10 ml of 40% glucose (D(+)-Glucose, manufactured by Wako Junpharma Co., Ltd.) was added 2 g of the above-mentioned MLCT (2) (trade name: Nissin Canoira Oil, manufactured by Nissin Oilio Group Co., Ltd.) and 200 mg of bovine serum albumin (manufactured by SIGMA), and the resulting solution was subjected to ultrasonic treatment while cooling on ice (5 minutes for two groups, 10 minutes in total), to obtain Sample 3.

[0068] The triacylglyceride composition and fatty acid...

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PUM

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Abstract

The present invention provides an oil and fat composition that is highly safe and effective in preventing or treating diabetes without worrying about side effects even if it is taken continuously. The grease composition for preventing or treating diabetes of the present invention is characterized by: containing triacylglyceride as an active ingredient, the triacylglyceride contains 1 or 2 medium-chain fatty acid residues in the molecule, and contains Medium-chain fatty acids with 6 to 10 carbon atoms and long-chain fatty acids with 16 to 24 carbon atoms are used as structural fatty acids.

Description

technical field [0001] The present invention relates to an oil composition for preventing or treating diabetes, in particular, to an oil composition for preventing or treating diabetes which uses a specific triacylglyceride as an active ingredient. Background technique [0002] Diabetes is roughly divided into type 1 diabetes (insulin-dependent diabetes) and type 2 diabetes (non-insulin-dependent diabetes). Most diabetic patients in Japan suffer from type 2 diabetes, which is caused by the worsening symptoms of insulin insufficiency in which insulin secretion is reduced or insulin resistance (insulin insufficiency) in which the effect of insulin on lowering blood sugar is weakened. These symptoms have a lot to do with genetic factors, partial eclipse, overeating, lack of exercise, stress and other environmental factors. [0003] In recent years, the number of patients with type 2 diabetes has been increasing, and it is reported that the number has reached 20 million people,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/22A23L1/30A61K31/23A61P3/10
CPCA23L1/3006A61K9/08A23V2002/00A61K31/23A61K9/0095A23L33/115A61P3/10A23V2200/328A23V2250/186
Inventor 青山敏明寺田新山本小百合
Owner THE NISSHIN OILLIO GRP LTD
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