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Material of soybean polysaccharide hollow capsule and production method of capsule

A technology of soybean polysaccharides and hollow capsules, applied in the direction of capsule transportation, etc., can solve the problems of high price and failure to meet the requirements of pharmaceutical factories, and achieve the effect of avoiding hidden dangers and unsightly appearance

Inactive Publication Date: 2014-02-26
石法堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the determination of the friability of the pullulan hollow capsules, although they meet the requirements of the Chinese Pharmacopoeia hollow capsules, they cannot meet the requirements of the pharmaceutical factory.
For pharmaceutical factories, 1% damage is unacceptable, because it is generally expensive to accept medicines or health care products filled with plant hollow capsules. The loss of filling powder, the accumulation of damage at 1% will cause huge economic losses

Method used

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  • Material of soybean polysaccharide hollow capsule and production method of capsule
  • Material of soybean polysaccharide hollow capsule and production method of capsule
  • Material of soybean polysaccharide hollow capsule and production method of capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063]

[0064] The specific operation process is as follows:

[0065] a. After fully mixing the above-mentioned solid components, add water to mix and stir evenly;

[0066] b. Dissolve the uniformly stirred mixture in step a in a 90°C water bath and remove all air bubbles, cool the water bath to 50°C, and keep it at 50°C for 30 minutes to form a colloid;

[0067] c. Then dip in glue, dry, cut, and fit together to obtain soybean polysaccharide hollow capsules;

[0068] The whole production process keeps the room temperature at 20°C-22°C.

[0069] The soybean polysaccharide hollow capsules prepared above were tested according to the regulations on friability and disintegration of gelatin hollow capsules in the Pharmacopoeia of the People's Republic of China.

[0070] Results: friability; 50 soybean polysaccharide hollow capsules were not damaged. The disintegration time limit is 15 minutes.

Embodiment 2

[0072]

[0073] The specific operation process is as follows:

[0074] a. After fully mixing the above-mentioned solid components, add water to mix and stir evenly;

[0075] b. Dissolve the uniformly stirred mixture in step a in a water bath at 85°C and remove all air bubbles, cool the water bath to 52°C, and keep it at 52°C for 35 minutes to form a colloid;

[0076] c. Then dip in glue, dry, cut, and fit together to obtain soybean polysaccharide hollow capsules;

[0077] The whole production process keeps the room temperature at 20°C-22°C.

[0078] The soybean polysaccharide hollow capsules prepared above were tested according to the regulations on friability and disintegration of gelatin hollow capsules in the Pharmacopoeia of the People's Republic of China.

[0079] Results: friability; 50 soybean polysaccharide hollow capsules were not damaged. The disintegration time limit was 13 minutes.

Embodiment 3

[0081]

[0082] The specific operation process is as follows:

[0083] a. After fully mixing the above-mentioned solid components, add water to mix and stir evenly;

[0084] b. Put the uniformly stirred mixture in step a into a 90°C water bath to dissolve and remove all air bubbles, cool down the water bath to 50°C, and keep it at 50°C for 40 minutes to form a colloid;

[0085] c. Then dip in glue, dry, cut, and fit together to obtain soybean polysaccharide hollow capsules;

[0086] The whole production process keeps the room temperature at 20-22°C.

[0087] The soybean polysaccharide hollow capsules prepared above were tested according to the regulations on friability and disintegration of gelatin hollow capsules in the Pharmacopoeia of the People's Republic of China.

[0088] Results: friability; 50 soybean polysaccharide hollow capsules were not damaged. The disintegration time limit is 15 minutes.

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Abstract

The invention provides a material of a soybean polysaccharide hollow capsule, and aims to solve the problems of poor friability and poor disintegration existing in the conventional hollow capsule. According to the technical scheme of the invention, the material comprises the following components in percentage by weight: 32-42 percent of soybean polysaccharides, 45-54 percent of pulullan polysaccharides, 2-10 percent of a humectant and 4-8 percent of a gel. The soybean polysaccharide hollow capsule is prepared from the material by the following steps of: a, fully mixing all components, adding water, mixing and stirring uniformly; b, putting a mixture obtained by stirring uniformly in the step a into a water bath for dissolving, removing air bubbles, cooling in a water bath, and preserving heat for 30-40 minutes to obtain a colloid; and c, dipping glue, drying, cutting and combining to obtain the soybean polysaccharide hollow capsule. The hollow capsule prepared by taking the material as a raw material has high friability and high disintegration, and the quality of the hollow capsule is not reduced if the hollow capsule is preserved for a long time.

Description

technical field [0001] The invention specifically relates to a material of a hollow capsule and a production method of the capsule, in particular to a material of a soybean polysaccharide hollow capsule and a production method of the capsule. Background technique [0002] At present, the main component of hollow capsules, including hard capsules and soft capsules, is gelatin. The production process is mainly to use gelatin extracted from animal skin and bone, and add some plasticizers, edible pigments and opacifiers to make gelatin liquid. Then use the mold to dip in glue, solidify and dry. This gelatin-produced capsule is easily affected by environmental changes and the ingredients of the contained medicine because the gelatin contains animal protein after being filled with medicine, and has defects such as brittleness, denaturation, and excessive disintegration time limit. And because gelatin is extracted from the skin of some animals, people who believe in Islam and Juda...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/48
Inventor 吕燮余
Owner 石法堂