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Stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using membrane-ultrasonic wave dissolving technique

A Taxus chinensis powder and thin-film ultrasound technology are applied in the directions of liposome delivery, medical preparations containing active ingredients, medical raw materials derived from gymnosperm subphylum, etc. The effect of reducing pollution and simple processing procedures

Inactive Publication Date: 2012-12-12
李振刚
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, paclitaxel oral preparations (decoction pieces, capsules) have not been widely used so far. One important reason is that intestinal cells have low absorption rate of paclitaxel (alkane) (<6 %)

Method used

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  • Stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using membrane-ultrasonic wave dissolving technique
  • Stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using membrane-ultrasonic wave dissolving technique
  • Stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using membrane-ultrasonic wave dissolving technique

Examples

Experimental program
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Effect test

Embodiment

[0035] (1) Materials:

[0036] ① Take 100g of yew extract powder (supplied by Kunming Green Young Biological Engineering Co., Ltd., paclitaxel content is 1%), degrease and remove impurities and grind into fine powder, and accurately measure the taxane content and paclitaxel content of yew extract;

[0037] ②Take the prescribed amount of egg yolk: take 500g of egg yolk powder, make egg yolk by ultrasonic strengthening method, remove the protein in the egg yolk, make it contain about 80% lecithin and a small amount of cholesterol, after accurately measuring the lecithin content of the egg yolk, press Taxanes: lecithin: cholesterol prescription volume ratio is 1: 29: 0.75 to get prescription volume egg oil;

[0038] ③Take the prescription amount of yew powder: calculate with the commercially available yew capsule containing 4.5 mg of paclitaxel as the reference amount:

[0039] Prescription amount of yew powder = total milligrams of paclitaxel contained in 100g extract ÷ 4.5× we...

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Abstract

The invention discloses a stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using a membrane-ultrasonic wave dissolving technique, belonging to the technical field of medicines. According to the invention, a traditional stir-frying method for Chinese herbal medicines is combined with advanced preparation and enrichment technologies for paclitaxel (taxane) liposome so as to process the Chinese yew powder which is rich in the paclitaxel (taxane) liposome, can be easily absorbed in oral administration and has a high efficiency anticancer effect and low toxic and side effects. The method comprises the following concrete steps: putting 95% ethanol and egg oil which are used as liquid accessories and Chinese yew powder and Chinese yew extract powder which are used as stir-frying substrates in a membrane evaporator together, carrying out stir-frying under the conditions of a constant temperature (a water bath at a temperature of 60 DEG C), pressure reduction and continuous rotation operation, carrying out hydration so as to form the paclitaxel (taxane) liposome and allowing the paclitaxel (taxane) liposome to be enriched in Chinese yew powder particles by using a vacuum / pressure method, thereby allowing the Chinese yew powder to become an anticancer Chinese herbal medicine which is rich in the paclitaxel (taxane) liposome, can be easily absorbed in oral administration and has high efficiency and low toxic and side effects.

Description

technical field [0001] The invention relates to a technique for preparing yew powder rich in paclitaxel liposome by film ultrasonic method, which belongs to [0002] in the field of medical technology. Background technique [0003] In recent years, due to the infiltration of modern pharmaceutical technology on the processing technology of traditional Chinese medicine powder, the efficacy of traditional Chinese medicine powder has been significantly improved, and new types of powders such as concentrated traditional Chinese medicine powder, nanometer traditional Chinese medicine powder, and traditional Chinese medicine ultrafine particles have appeared successively. For most Chinese herbal medicines, it avoids the disadvantages of troublesome decoction and inconvenient taking, and enables the active ingredients of the medicine to be concentrated or fully released to a certain extent, thereby greatly improving the efficacy of the medicine powder. However, grinding, releasing,...

Claims

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Application Information

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IPC IPC(8): A61K36/13A61K9/48A61K9/127A61K31/337A61P35/00
Inventor 李振刚
Owner 李振刚
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