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Aceclofenac enteric-coated pellet particle composition and preparation method thereof

A technology of aceclofenac and composition, applied in the field of aceclofenac enteric-coated micropill composition and its preparation field, can solve the problems of indigestion, small distribution area, low dissolution rate and the like, and achieve good bioavailability , good taste and easy operation

Active Publication Date: 2012-12-19
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But because aceclofenac itself has pungent feeling, there is the problem of bad oral taste in common oral preparation; irritant
Existing aceclofenac preparations have small distribution area, low dissolution rate and low bioavailability in the gastrointestinal tract, which reduces the curative effect of the drug itself

Method used

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  • Aceclofenac enteric-coated pellet particle composition and preparation method thereof
  • Aceclofenac enteric-coated pellet particle composition and preparation method thereof
  • Aceclofenac enteric-coated pellet particle composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Accurately weigh 2.5g of binder (sodium carboxymethylcellulose) and add 500mL of water to prepare a binder solution, then add 50g of aceclofenac, 720g of starch, and 30g of lactose to prepare a pellet core with a diameter of 1.0mm;

[0051] Take 25g of acrylic resin No. Ⅱ, 5.5mL of Tween-80, 20mL of castor oil, 750mL of ethanol and 20g of talcum powder to prepare the coating solution;

[0052] In g / mL, take the ball core and the coating solution according to the mass volume ratio of 700:900, mix and then coat, to obtain.

Embodiment 2

[0054] Accurately weigh 0.5g of binder (sodium carboxymethylcellulose) and add 100mL of water to prepare a binder solution, then add 45g of aceclofenac, 680g of starch, and 20g of lactose to prepare a pellet core with a diameter of 1.1mm;

[0055] Take 35g of acrylic resin No. Ⅱ, 6.0mL of Tween-80, 10mL of castor oil, 770mL of ethanol and 30g of talcum powder to prepare the coating solution;

[0056] In g / mL, take the ball core and the coating solution according to the mass volume ratio of 800:750, mix them and coat them.

Embodiment 3

[0058] Accurately weigh 1.5g of binder (sodium carboxymethylcellulose) and add 300mL of water to prepare a binder solution, then add 55g of aceclofenac, 797.5g of starch, and 25g of lactose to prepare a pellet core with a diameter of 1.0mm ;

[0059] Take 30g of acrylic resin No. Ⅱ, 4.0mL of Tween-80, 15mL of castor oil, 730mL of ethanol and 25g of talcum powder to prepare the coating liquid;

[0060] In g / mL, take the ball core and the coating solution according to the mass-volume ratio of 750:800, mix them, and then coat them.

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Abstract

The invention relates to the field of a medicinal preparation, in particular to an aceclofenac enteric-coated pellet particle composition and a preparation method of the aceclofenac enteric-coated pellet particle composition. The aceclofenac enteric-coated pellet particles are higher in dissolution rate due to the fact that the dissolution rate is more than 75% within 45 minutes, the bioavailability is better and reaches up to 92.67%, and the taste is better. The preparation method is convenient to operate, thereby being suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an aceclofenac enteric-coated pellet composition and a preparation method thereof. Background technique [0002] Inflammation is a very common and important basic pathological process. Trauma infection on the body surface and most common and frequently-occurring diseases of various organs (such as boils, carbuncles, pneumonia, hepatitis, nephritis, etc.) are all inflammatory diseases. A defensive response to irritation manifested by redness, swelling, heat, pain, and dysfunction. Among them, acute inflammation is the immediate and early response of the body to the stimulation of inflammatory factors. The main feature of acute inflammation is the exudative change centered on the vascular response, which causes the white blood cells and antibodies in the blood vessels to enter the inflammatory response site through the blood vessel wall, eliminate pathogens, dilute and n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/216A61P29/00
Inventor 冯长银李明杰刘明霞
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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