Chinese medicinal composition for treating idiopathic facial paralysis and preparation method thereof
A technique for facial paralysis and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of idiopathic facial paralysis, which can solve the problems of poor individuality, high toxicity and side effects, strong drug resistance, etc. high effect
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[0042] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is a decoction, it includes the following steps,
[0043] In the first step, the components in the traditional Chinese medicine composition are mixed in proportion, crushed into powders of 40 mesh to 60 mesh, and then soaked in cold water 4 to 6 times the mass of the mixture for 30 minutes to 1 hour, heated to boil, and decocted The cooking time is 3 hours to 5 hours, and the decoction is filtered to obtain the first filtrate;
[0044] In the second step, the filter residue obtained by filtering in the first step is added to cold water 3 to 5 times its mass, heated and boiled for 2 hours to 3 hours, filtered to obtain the second filtrate, and the two filtrates are combined to obtain The decoction.
[0045] The present invention also provides a preparation method of the above-mentioned Chinese medicine com...
Embodiment 1
[0084] The decoction 1 that embodiment 1 present invention prepares
[0085] Guizhi 47g, Arctium 22g, Aconite 58g, Earthworm 28g, Styrax 30g, Gastrodia elata 74g, Codonopsis 61g, Acanthopanax 37g, lotus seeds 29g, Eucommia 22g, Salvia miltiorrhiza 37g, Achyranthes bidentata 42g, Cyrrhizae 27g, Daxueteng Mix 30g, Jiulixiang 18g, Peach Kernel 31g, Geranium 37g, Mustard Seed 16g, Angelica 27g, Selaginella 34g, Benzoin 15g, Tangerine Peel 22g, Dried Ginger 19g, Licorice 31g, crush into 50 mesh powder, then soak in 4000g of cold water 1 hour, heat to boil, decoct for 4 hours, filter the decoction to obtain the first filtrate, add the filtered residue to 500 g of cold water again, heat to boil, decoct for 3 hours, and filter to obtain the second filtrate , combined two filtrates to obtain the decoction 1.
Embodiment 2
[0086] Embodiment 2 acute toxicity test:
[0087] Get 40 ICR mice (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.), with a body weight of 25 to 30 grams. The decoction 1 prepared in Example 1 is administered to the mice. (LD 50 ) was experimentally determined, but LD was not detected 50 , so the maximum tolerated dose test was carried out. Result: with maximum concentration (60%), maximum administration, crude drug amount 60g / kg, is equivalent to 300 times (by 75kg) of adult's clinical proposed daily dosage, within seven days, none of mice dies, puts to death mouse anatomy observation each No toxic reaction was found in the organs, and there was no difference between the administration group and the control group mice.
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