Chinese medicinal composition for treating idiopathic facial paralysis and preparation method thereof

A technique for facial paralysis and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of idiopathic facial paralysis, which can solve the problems of poor individuality, high toxicity and side effects, strong drug resistance, etc. high effect

Inactive Publication Date: 2012-12-26
北京邈传中医药科技院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Western medicine has long been recognized for the treatment of idiopathic facial paralysis. Adrenal cortex hormones such as dexamethasone can quickly relieve facial nerve inflammation and edema, and B vitamins can be used to promote nerve myelin recovery. Acyclovir interferes with viral deoxygenation. Ribonucleic acid (DNA) polymerase inhibits the replication of viral DNA. However, although simple Western medicine treatment has a certain curative effect, some patients still have sequelae in varying degrees, and Western medicines are expensive, have large toxic and side effects, and strong drug resistance. , the individuality of the treatment is poor, and the curative effect is not very satisfactory
[0005] Acupuncture and moxibustion can reduce and eliminate the edema around the idiopathic facial nerve paralysis. Modern acupuncture and moxibustion physiological experiments have proved that acupuncture and moxibustion can improve the blood circulation of the capillaries around the lesion and enhance the immune function of the human body, thereby reducing or eliminating the edema around the facial nerve and reducing the pressure on the facial nerve. Unstressed, but traditional Chinese medicine theory does not advocate acupuncture treatment. The strong stimulation of acupuncture will cause vasoconstriction, but acupuncture can promote the regeneration and repair of ischemic damaged neurons, restore innervation function, improve nerve conduction, and improve nerve function. Excitability, protect the activity of various enzymes in the cell membrane, delay and weaken the necrotic process of ischemic nerve cells, and promote the repair of ischemic areas

Method used

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  • Chinese medicinal composition for treating idiopathic facial paralysis and preparation method thereof

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preparation example Construction

[0042] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is a decoction, it includes the following steps,

[0043] In the first step, the components in the traditional Chinese medicine composition are mixed in proportion, crushed into powders of 40 mesh to 60 mesh, and then soaked in cold water 4 to 6 times the mass of the mixture for 30 minutes to 1 hour, heated to boil, and decocted The cooking time is 3 hours to 5 hours, and the decoction is filtered to obtain the first filtrate;

[0044] In the second step, the filter residue obtained by filtering in the first step is added to cold water 3 to 5 times its mass, heated and boiled for 2 hours to 3 hours, filtered to obtain the second filtrate, and the two filtrates are combined to obtain The decoction.

[0045] The present invention also provides a preparation method of the above-mentioned Chinese medicine com...

Embodiment 1

[0084] The decoction 1 that embodiment 1 present invention prepares

[0085] Guizhi 47g, Arctium 22g, Aconite 58g, Earthworm 28g, Styrax 30g, Gastrodia elata 74g, Codonopsis 61g, Acanthopanax 37g, lotus seeds 29g, Eucommia 22g, Salvia miltiorrhiza 37g, Achyranthes bidentata 42g, Cyrrhizae 27g, Daxueteng Mix 30g, Jiulixiang 18g, Peach Kernel 31g, Geranium 37g, Mustard Seed 16g, Angelica 27g, Selaginella 34g, Benzoin 15g, Tangerine Peel 22g, Dried Ginger 19g, Licorice 31g, crush into 50 mesh powder, then soak in 4000g of cold water 1 hour, heat to boil, decoct for 4 hours, filter the decoction to obtain the first filtrate, add the filtered residue to 500 g of cold water again, heat to boil, decoct for 3 hours, and filter to obtain the second filtrate , combined two filtrates to obtain the decoction 1.

Embodiment 2

[0086] Embodiment 2 acute toxicity test:

[0087] Get 40 ICR mice (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.), with a body weight of 25 to 30 grams. The decoction 1 prepared in Example 1 is administered to the mice. (LD 50 ) was experimentally determined, but LD was not detected 50 , so the maximum tolerated dose test was carried out. Result: with maximum concentration (60%), maximum administration, crude drug amount 60g / kg, is equivalent to 300 times (by 75kg) of adult's clinical proposed daily dosage, within seven days, none of mice dies, puts to death mouse anatomy observation each No toxic reaction was found in the organs, and there was no difference between the administration group and the control group mice.

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Abstract

The invention provides a Chinese medicinal composition for treating idiopathic facial paralysis. The Chinese medicinal composition comprises cassia twig, great burdock achene, giant typhonium rhizome, earthworm, storax, tall gastrodia tuber, dangshen, acanthopanax root, lotus seed, cortex eucommiae, red-rooted salvia root, twotooth achyranthes root, Chinese mosla herb, sargentg loryvine stem, common jasminorange leaf and twig, peach kernel, geranium wilfordii, India mustard seed, Chinese angelica, tamariskoid spikemoss herb, benzoin, dried orange peel, dried ginger and liquoric root. The Chinese medicinal composition provided by the invention has the advantages of short treatment course, good curative effect and freeness from toxic and side effects in comparison to a Chinese medicine on the aspect of treatment of idiopathic facial paralysis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating idiopathic facial paralysis. Background technique [0002] Idiopathic facial paralysis, also known as Bell's palsy or facial neuritis, is a peripheral facial paralysis caused by non-specific inflammation of the facial nerve in the stylomastoid foramen. The disease has a higher incidence rate when the temperature changes suddenly in winter, spring or autumn and winter every year. If it is not treated in time, the patient may leave behind various sequelae such as facial nerve spasm, facial muscle joint movement, and facial paralysis. Both physically and psychologically cause great pain. The disease can occur at any age, and it is more common in 20-40 years old. There are more men than women. Most of them are unilateral facial expression muscle paralysis. Self-relief. [0003] The etiology of idiopathic f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61P25/02A61K35/64A61K35/62
Inventor 孙霞
Owner 北京邈传中医药科技院
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