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Preparation method of sargassum fusiforme selenium polysaccharide

A hijiki polysaccharide and selenium polysaccharide technology, which is applied in the direction of drug combination, antineoplastic drugs, allergic diseases, etc., can solve the problems of toxicity, cumbersome operation of selenium polysaccharide, irritating odor reagents, etc., to improve phagocytosis activity, improve The immune function of the body and the effect of no irritating smell

Inactive Publication Date: 2013-01-02
HARBIN UNIV OF COMMERCE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method of hijiki selenium polysaccharide in order to solve the technical problems of complex operation, pungent smell and toxic reagents in the existing method for synthesizing selenium polysaccharide

Method used

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  • Preparation method of sargassum fusiforme selenium polysaccharide
  • Preparation method of sargassum fusiforme selenium polysaccharide
  • Preparation method of sargassum fusiforme selenium polysaccharide

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specific Embodiment approach 1

[0036] Specific embodiment one: the preparation method of hijiki selenium polysaccharide of this embodiment is carried out according to the following steps:

[0037] 1. To 100ml volume fraction of 0.5% HNO 3 Add 1g of hijiki polysaccharide to the aqueous solution to obtain a polysaccharide solution;

[0038] 2. Add sodium selenite to the polysaccharide solution to obtain a mixed solution. The mass ratio of sodium selenite to hijiki polysaccharide in the mixed solution is 0.4 to 1.2g: 1g, and then put it in a water bath at 50°C to 90°C Shake the reaction for 6-10 hours, cool down, and then add NaCO 3 Adjust the pH value to 5-6, centrifuge, and then dialyze until the dialysate is added with ascorbic acid to detect no red color, stop dialyzing, heat, concentrate, and freeze-dry to obtain hijiki selenium polysaccharide.

specific Embodiment approach 2

[0039] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass ratio of sodium selenite to hijiki polysaccharide in the mixed solution described in step 2 is 0.6g:1g. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0040] Specific embodiment three: the difference between this embodiment and specific embodiment one is that the mass ratio of sodium selenite to hijiki polysaccharide in the mixed solution described in step two is 0.9g:1g. Others are the same as in the first embodiment.

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Abstract

The invention provides a preparation method of sargassum fusiforme selenium polysaccharide, and relates to a preparation method of polysaccharide, aiming at solving the technical problems that the existing selenium polysaccharide synthesizing method is complex to operate, the synthesized selenium polysaccharide is pungent in smell, and the used reagent is toxic. The method comprises the following steps of: 1, adding 1g of sargassum fusiforme polysaccharide into 100mL of 0.5% by volume HNO3 water solution to obtain a polysaccharide solution; 2, adding sodium selenite into the polysaccharide solution to obtain a mixed solution, wherein the mass ratio of sodium selenite to the sargassum fusiforme polysaccharide in the mixed solution is (0.4-1.2g):1g, reacting for 6-10hours at the temperature of 50DEG C-90DEG C, cooling, adding NaCO3 to adjust the pH value to 5-6, centrifuging, dialyzing till the red is not detected to be unavailable after ascorbic acid is added into dialyzate, heating and concentrating, and carrying out freeze drying to obtain the sargassum fusiforme selenium polysaccharide. The preparation method provided by the invention is simple to operate, and free of pungent smell, and the used reagent is non-toxic and environment-friendly.

Description

technical field [0001] The invention relates to a preparation method of polysaccharide. Background technique [0002] In recent years, the methods for synthesizing selenium polysaccharides mainly include the following: [0003] (1) the SeO 3 2- Replacement of sulfate-SO in sulfated polysaccharides 3 - Adding selenium to polysaccharides, and others such as SeOCl 2 Oscillation reactions with polysaccharides, etc., but these methods still have the disadvantages of relatively single selenium structure and low selenium content. Taking Ganoderma lucidum selenium polysaccharide as an example, add 30ml of pyridine into a 100ml three-necked bottle with a condenser and a stirring device, add 2.5-3.0g of selenium trioxide-pyridine while stirring, heat to 90°C in a hot water bath, and then Add 0.5 g of polysaccharide powder, stir at constant temperature, and cool to room temperature; the oscillating reaction solution is adjusted to neutrality with 3 mol / L NaOH solution, and 95% e...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P35/00A61P37/04
Inventor 季宇彬于淼东方
Owner HARBIN UNIV OF COMMERCE
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