Method of calculating substance concentration in 1H-MRS (1H-magnetic resonance spectrum)

A 1H-MRS, substance concentration technology, applied in the direction of using magnetic variable measurement, using nuclear magnetic resonance imaging system for measurement, magnetic resonance measurement, etc.

Inactive Publication Date: 2013-01-02
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] 2) For 1 For some overlapping peaks in H-MRS, such as the overlapping high-concentration metabolite Cr and low-concentration metabolite GABA at 3.00ppm, the LC-model cannot separate and extract the overlapping peak GABA, and cannot accurately calculate the peak. concentration of substance
[0008] 3) Due to the limitations of the LC-model algorithm, the peaks represented by some substances outside the LC-model standard library cannot be calculated and processed
With the continuous development of 1H-MRS research, some special pulse sequences to detect the concentration of certain specific metabolites have been developed, such as the mega-PRSS sequence used to detect GABA, and the LC-model cannot process the data collected by these sequences.

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  • Method of calculating substance concentration in 1H-MRS (1H-magnetic resonance spectrum)
  • Method of calculating substance concentration in 1H-MRS (1H-magnetic resonance spectrum)
  • Method of calculating substance concentration in 1H-MRS (1H-magnetic resonance spectrum)

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Embodiment 1

[0060] Example 1. Calculation of the concentration of common high-concentration metabolites in clinical practice, such as NAA, Cr, Cho, etc.:

[0061] Acquisition of 10 Human Brains Using PRESS Sequence on a Siemens 3T Magnetic Resonance Instrument 1 H-MRS data. First, the wavelet threshold method was used to denoise the data, and then the area under the peak of Cr was calculated one by one by the calculation method of the area under the peak of the single peak described in this paper, and converted into concentration.

[0062] In the following, a specific clinical 1 The H-MRS data is used as an example to illustrate the specific calculation process of this algorithm. image 3 collected for clinical 1 H-MRS spectral data, Figure 4 obtained after wavelet analysis 1 H-MRS spectrogram.

[0063] will be obtained through wavelet analysis 1 The peak Cr (3.00ppm) in the H-MRS spectrogram is extracted to the starting point, see Figure 5 , the abscissa indicates the peak posi...

Embodiment 2

[0069] Embodiment 2, multiple peaks, such as GABA, etc., the calculation of the area under the peak of low-concentration metabolites:

[0070] The press sequence and mega-PRESS sequence were used to collect the data of the same part of seven human brains (both sequences use the same voxel) on a Siemens 3T magnetic resonance instrument, and then the area under the GABA peak obtained by the two sequences was calculated respectively. The calculation method of this paper is used for the PRESS sequence; the mega-PRESS sequence is a clinically specific sequence for detecting GABA, which is used for comparison with the calculation method of this paper. Table 2 shows the calculation results of the two methods. It can be seen that the two calculation results are highly consistent.

[0071] Table 2 Comparison between the patented algorithm and the mega-PRESS results when calculating the GABA concentration

[0072]

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Abstract

The invention discloses a method of accurately calculating concentration of every substance in a 1H-MRS (1H-magnetic resonance spectrum), which is suitable for a scanning sequence of all 1H-MRSes. The method comprises the steps of: eliminating noise by a wavelet threshold method to improve a signal-noise ratio of signals; calculating the under-peak area of wave peaks by extracting data points of the wave peaks and gradually performing curve fitting on wave peaks, and performing conversion of the under-peak area and the substance concentration by an internal standard method. The calculation process can be subjected to editing treatment according to actual data collected in the clinics, the peak position, the full width of the peak at half maximum, the under-peak area and other parameters in the calculation process can be obtained, and the method has the advantages of editable performance, high accuracy, good repeatability and the like. By adopting the method, changes in the concentration of all metabolites in the brain can be accurately calculated and subjected to in-vivo monitoring, and dynamic tracking can be performed. Therefore, the method has importance clinical value and significance in research of pathogenesis of certain diseases of the brain such as addiction, epilepsia, senile dementia and tumor.

Description

technical field [0001] The present invention relates to a kind of accurate calculation proton magnetic resonance spectrum (Proton Magnetic Resonance Spectroscopy, 1 H-MRS) method for the concentration of each substance. Background technique [0002] Proton Magnetic Resonance Spectroscopy, 1 H-MRS) imaging technology is an effective method for in vivo, non-invasive detection of brain metabolites and can quantitatively measure the concentration of these metabolites. Observing changes in the concentration of metabolites in the brain can provide important information for understanding the physiological and pathological activities of the brain. Therefore, 1 H-MRS has been widely used in clinical practice. In the healthy brain, metabolites that can usually be observed in vivo include N-acetylaspartic acid (NAA), choline (Cho), creatine (tCr), inositol (myo-inosito, Ins), lipids ( Lipid), glutamic acid complex (Glu\Gln——Glx), γ-aminobutyric acid (GABA), etc. [0003] Clinical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/54
Inventor 全红王成杨志勇
Owner WUHAN UNIV
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