Hydrochloric acid vilazodone quick-release tablet and preparation method thereof

Abstract

The invention discloses a hydrochloric acid vilazodone quick-release tablet and a preparation method thereof. The hydrochloric acid vilazodone quick-release tablet comprises the follow components by mass: 2-12% of hydrochloric acid vilazodone, 28-45% of lactose, 40-60% of microcrystalline cellulose, 0.5-3% of lubricants and 1-5% of coating materials. The lubricants include magnesium stearate and colloidal condition silica or one of the magnesium stearate and the colloidal condition silica. The hydrochloric acid vilazodone quick-release tablet is prepared through the following steps: evenly mixing the hydrochloric acid vilazodone, the lactose, the microcrystalline cellulose and the lubricants according to proportion of a formula, detecting whether content uniformity is qualified, and pressing the mixture into tablets when the content uniformity is qualified. The hydrochloric acid vilazodone quick-release tablet has special requirements for grain size of the hydrochloric acid vilazodone, and the preparation process saves time and labor, reduces energy consumption and improves production efficiency. Disintegration speed of medicines is fastened, the dissolving-out time is obviously less than that of a prescription which has no limitation on the grain size of the hydrochloric acid vilazodone, and simultaneously the process which directly performs mixing tabletting greatly improves stability of the medicines in preparations.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology preparation, and in particular relates to a vilazodone hydrochloride quick-release tablet for treating severe depression and a preparation method thereof. Background technique [0002] Depression is a common mental illness. The main clinical manifestations are low mood, loss of interest but not loss, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, and worry that you have various diseases. Illness, I feel discomfort in many parts of the body, and in severe cases, suicidal thoughts and behaviors may appear. According to the statistics of the World Health Organization, the global incidence of depression is about 3.1%, while in developed countries it is close to about 6%. There are 120 million patients with depression worldwide, and it has become the fourth largest disease that threatens human health. With the increasing pace of life and increasing competition, ...

AI Technical Summary

Problems solved by technology

[0016] The object of the present invention is to provide a kind of vilazodone hydrochloride quick-release tablet and preparation method thereof, solve the vilazodone hydrochloride solubility difference, dissolution rate is slow, the shortcoming that bioavailability is not high; And preparation method of the present invention can Avoid the crystal transformation of vilazodone hydrochloride crystal form caused by external factors such as damp heat and repeated extrusion, and ensure that the stable crystal form IV of vilazodone hydrochloride in the product will not be transformed

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