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Method for preparing Wei shuxin preparation

A Weishuxin preparation technology, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low extraction efficiency of active ingredients and unsatisfactory clinical curative effect of Weishuxin capsules, etc.

Inactive Publication Date: 2013-01-16
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method for producing Weishuxin Capsules generally adopts standard numbering: standard numbering: WS-11501 (ZD-1501)-2002. In the method recorded in the above-mentioned standard, all medicines are decocted and extracted with water. The method is relatively simple, resulting in product It contains a lot of ineffective ingredients and impurities, and the extraction efficiency of active ingredients is low, which makes the clinical efficacy of Weishuxin Capsules unsatisfactory.

Method used

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  • Method for preparing Wei shuxin preparation
  • Method for preparing Wei shuxin preparation
  • Method for preparing Wei shuxin preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Prescription: Asplenia 333.3g, Geshanxiao 333.3g.

[0055] Process: Crush asplenium and Geshanxiao respectively into coarse powder, add 12 times the amount of 70% ethanol to extract 2 times, each time for 1 hour, filter, combine filtrates, recover ethanol under reduced pressure, and concentrate to relative density It is a thick paste with a temperature of 1.20-1.30 at 50-60°C, and it is used for later use; Geshanxiao coarse powder is extracted 6 times at 62°C with 25 times the amount of extraction agent composed of methanol 97%, acetic acid 1.5%, and water 1.5%. Radiation extraction for 50s each time, take out, filter, combine the filtrate, after cooling to room temperature, wash with anhydrous NaSO 4 After drying for 24 hours, filter, and the filtrate is recovered by vacuum distillation to obtain the extract, which is concentrated into a thick paste with a relative density of 1.20-1.30 at 50-60°C for later use; the two thick pastes are combined and added to make 95% T...

Embodiment 2

[0058] Prescription: 400g of Asplenium asplenium, 300g of Geshanxiao.

[0059] Process: Crush asplenium and Geshanxiao respectively into coarse powder, add 12 times the amount of 70% ethanol to extract 2 times, each time for 1 hour, filter, combine filtrates, recover ethanol under reduced pressure, and concentrate to relative density It is a thick paste with a temperature of 1.20-1.30 at 50-60°C, and it is used for later use; Geshanxiao coarse powder is extracted 6 times at 62°C with 25 times the amount of extraction agent composed of methanol 97%, acetic acid 1.5%, and water 1.5%. Radiation extraction for 50s each time, take out, filter, combine the filtrate, after cooling to room temperature, wash with anhydrous NaSO 4 Dry for 24 hours and then filter, the filtrate is recovered by vacuum distillation to obtain the extract, concentrated into a thick paste with a relative density of 1.20-1.30 at 50-60°C, and set aside; combine the two thick pastes and add 10% of the prepared a...

Embodiment 3

[0063] Recipe: 300g of Asplenium asplenium, 400g of Geshanxiao.

[0064] Process: Crush asplenium and Geshanxiao respectively into coarse powder, add 12 times the amount of 70% ethanol to extract 2 times, each time for 1 hour, filter, combine filtrates, recover ethanol under reduced pressure, and concentrate to relative density It is a thick paste with a temperature of 1.20-1.30 at 50-60°C, and it is used for later use; Geshanxiao coarse powder is extracted 6 times at 62°C with 25 times the amount of extraction agent composed of methanol 97%, acetic acid 1.5%, and water 1.5%. Radiation extraction for 50s each time, take out, filter, combine the filtrate, after cooling to room temperature, wash with anhydrous NaSO 4 Dry for 24 hours and then filter, the filtrate is recovered by vacuum distillation to obtain the extract, concentrated into a thick paste with a relative density of 1.20-1.30 at 50-60°C, and set aside; combine the two thick pastes and add 10% of the prepared amount ...

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Abstract

The invention discloses a method for preparing a Wei shuxin preparation. The Wei shuxin preparation is prepared from spleenwort, radix cynanchi bungei and auxiliary materials. According to the properties of all medicines in the Wei shuxin preparation and the effects of all the medicines in a prescription, a process for the preparation is optimized by the invention. Compared with the prior art, the Wei shuxin preparation prepared by the method disclosed by the invention is higher in effective component content and better in clinical efficacy.

Description

technical field [0001] The invention relates to a preparation method of Weishuxin preparation, which belongs to the field of pharmaceutical technology. technical background [0002] Burning pain in the epigastric cavity, body heat, noisy hunger, dry mouth and throat, red tongue with little fluid, thready and rapid pulse, dry and hard stools, short red urine, etc. are mostly caused by excessive stomach heat, loss of stomach yin and disharmony between liver and stomach Clinical manifestations of epigastric pain. Traditional Chinese medicine often treats such epigastric pain with the methods of clearing heat and detoxifying, nourishing yin and benefiting the stomach, strengthening the spleen and harmonizing the stomach to achieve a curative effect. Weishuxin Granules is a kind of treatment for gastric fever, which is made from two traditional Chinese medicines, namely Asplenium fern with the functions of clearing heat and detoxifying, harmonizing the stomach, relieving pain, d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61K9/16A61K9/20A61K9/48A61P1/04
Inventor 黄文荣马静周菲娅
Owner GUIZHOU BAIHUA PHARMA