Refining method of ibuprofen

A refining method and technology of preparation steps, applied in the field of medicine, can solve the problems of not being able to reach the injection level, unknown side effects, many adverse reactions, and high impurity content, and achieve the effects of avoiding adverse reactions, easy operation, and simple process
CN102875360AInactive Publication Date: 2013-01-16WUXI XINRENTANG PHARMA TECH
4 Cites 7 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUXI XINRENTANG PHARMA TECH
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a refining method of ibuprofen, particularly relating to a refining process of the ibuprofen, impurity limit and quality comparison with the commercially available ibuprofen at present, and belonging to the technical field of medicine. The ibuprofen is mainly dissolved by using an organic solvent, active carbon is added for reflux decolorizing and then solution is crystallized, filtered, ground, dried and weighed to obtain a finished product, i.e., refined ibuprofen. According to the product prepared by the invention, the impurity content of the ibuprofen can be strictly controlled within a certain range, and requirements of all formations including injection can be met, so that adverse reaction produced to a human body can be avoided to the greatest extent and the safety is higher during intravenous drip and other administration approaches of a patient. The refining process of the ibuprofen has the advantages of simplicity, easiness in operation, high efficiency and capability of preparing a product with stable quality.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a refining method of ibuprofen, in particular to a refining process of ibuprofen, the limit of impurities and its quality comparison with the current commercially available ibuprofen, and belongs to the technical field of medicine. Background technique

[0002] Ibuprofen, also known as 2-(4-isobutylphenyl) propionic acid, is a class of non-steroidal anti-inflammatory drugs that have been used for many years. It has good anti-inflammatory, antipyretic and analgesic effects, and is especially suitable for the treatment of Rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis, etc.

[0003] Ibuprofen was first launched in the UK in 1968. Due to its remarkable antipyretic and analgesic effects and low toxicity, it is better than aspirin and paracetamol, so the market has expanded rapidly. Due to the better curative effect and less adverse reactions of ibuprofen, in the late 1980s, the Unit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More