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Polyether block copolymer and preparation method thereof

A polyether block and copolymer technology, applied in the field of polymers, can solve the problems of no modifiable side groups, limited applications, and can not provide hydrophobic groups, etc., and achieves high use value and good cell targeting. The effect of sex, wide application prospect

Active Publication Date: 2013-01-16
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the polyethers in the prior art do not have modifiable side groups and cannot provide hydrophobic groups, making them mainly used in the modification of protein drugs, which limits the application of polyethers in the biomedical field

Method used

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  • Polyether block copolymer and preparation method thereof
  • Polyether block copolymer and preparation method thereof
  • Polyether block copolymer and preparation method thereof

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preparation example Construction

[0053] The present invention provides a kind of preparation method of polyether block copolymer described in above-mentioned technical scheme, comprises the following steps:

[0054] a) performing a first polymerization reaction with an anionic initiator and a first polymerizable monomer in an anhydrous solvent to obtain a polyether homopolymer;

[0055] b) performing a second polymerization reaction on the polyether homopolymer obtained in step a) and the second polymerizable monomer to obtain a polyether block copolymer;

[0056] Described anionic initiator is prepared according to the following method:

[0057] Under the atmosphere of inert gas, react the condensed ring aromatic hydrocarbon with 1~5 benzene ring number and alkali metal in anhydrous solvent to obtain the first reaction product;

[0058] reacting the first reaction product with an alcohol compound having 1 to 10 carbon atoms to obtain an anionic initiator;

[0059] The first polymerizable monomer and the se...

Embodiment 1

[0075] Under the atmosphere of dry inert gas, add 5 g (0.039 mol) of naphthalene, 1.52 g (0.039 mol) of potassium and 100 mL of anhydrous tetrahydrofuran to a dry and clean reaction flask, react at 15 °C for 5 h, then add 3-allyl alcohol 2.26g (0.039mol), reacted at 15°C for 24h to obtain an anionic initiator.

Embodiment 2

[0077] Under the atmosphere of dry inert gas, add 5g (0.039mol) of naphthalene, 1.52g (0.039mol) of potassium and 100mL of anhydrous tetrahydrofuran to a dry and clean reaction flask, react at 25°C for 5h, then add 3-allyl alcohol 2.26g (0.039mol), reacted at 25°C for 24h to obtain an anionic initiator.

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Abstract

The invention provides a polyether block copolymer which has a structure as shown in formula (I). The polyether block copolymer provided by the invention has an amphiphilic group, which provides the obtained polyether block copolymer with amphiphilicity, and thus the polyether block copolymer can be self-assembled into nanoparticles and can be used as a drug carrier and the like; end groups and / of side groups of the polyether block copolymer provided by the invention have double bond function groups, and thus through reactions of a mercapto group with the double bonds, the modification of the polyether block copolymer is realized; the polyether block copolymer is provided with functions of tissue and cell targeting, environment responsiveness and the like; therefore, the polyether block copolymer provided by the invention has high application value and wide application prospects in biomedicine. Experiment results show that the polyether block copolymer provided by the invention can be modified by folic acid further, and the obtained folic acid-modified polyether block copolymer has cell targeting; the method for preparing the polyether block copolymer provided by the invention has a yield of about 90%.

Description

technical field [0001] The invention relates to the technical field of polymers, in particular to a polyether block copolymer and a preparation method thereof. Background technique [0002] Polyether, that is, polyethylene oxide, is a class of (-CH 2 CH 2 O-) is the polymer of the structural unit. Polyether is widely used in the biomedical field because it has the following excellent properties: [0003] 1. The synthesis method is simple and controllable. Polyethers are mainly prepared by anionic living ring-opening polymerization, which is the classical and most efficient method for the synthesis of well-defined block copolymers. End-functionalized polymers can be obtained by anionic polymerization technology, and block copolymers can be obtained by sequential feeding; [0004] 2. Good solubility in water. Polyethers have high solubility in water, phosphate buffered saline and saline; [0005] 3. The toxic and side effects on the human body are very small. Polyether...

Claims

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Application Information

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IPC IPC(8): C08G65/22C08G65/12A61K47/34
Inventor 丁建勋陈学思庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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