Degraded glass ceramic thin film for medical magnesium alloy surface and preparation method of degraded glass ceramic thin film

A glass-ceramic and magnesium alloy technology, applied in the fields of medical science, prosthesis, coating, etc., can solve the problem of not realizing the controllable degradation of magnesium alloy surface coating

Inactive Publication Date: 2013-01-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the above-mentioned coatings have made breakthroughs in biocompatibility, bioactivity, and

Method used

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  • Degraded glass ceramic thin film for medical magnesium alloy surface and preparation method of degraded glass ceramic thin film
  • Degraded glass ceramic thin film for medical magnesium alloy surface and preparation method of degraded glass ceramic thin film
  • Degraded glass ceramic thin film for medical magnesium alloy surface and preparation method of degraded glass ceramic thin film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: CaO-P 2 o 5 -Na 2 O-ZnO glass ceramic film

[0024] with P 2 o 5 , Ca(NO 3 ) 2 4H 2 O, NaNO 3 , Zn(NO 3 ) 2 ·6H 2 O is raw material, press P 2 o 5 -CaO-Na 2 O mole percentage 47:47:6 accurately weighed 1.669 grams of P 2 o 5 , 2.773 g Ca(NO 3 ) 2 4H 2 O, 0.256 g NaNO 3 ;Press Zn(NO 3 ) 2 ·6H 2 O%=2mol% weighs 0.140 grams of Zn (NO 3 ) 2 ·6H 2 O.

[0025] (1) Preparation of P 2 o 5 Precursor solution: the weighed P 2 o 5 Slowly add 22.5ml of absolute ethanol and stir vigorously for 1~2h to form a stable transparent solution. Due to the violent reaction between phosphorus pentoxide and ethanol, a large amount of heat is released, so the P2 o 5 When adding to ethanol, it must be added slowly in a small amount, and it must be stirred quickly to release the heat quickly.

[0026] (2) Preparation of inorganic salt solution: Measure 10ml of ethylene glycol and 15ml of ethanol solution, and weigh the Ca(NO 3 ) 2 4H 2 O, NaNO 3 , Zn...

Embodiment 2

[0030] Example 2: CaO-P 2 o 5 -Na 2 O-SrO glass ceramic film

[0031] with P 2 o 5 , Ca(NO 3 ) 2 4H 2 O, NaNO 3 , Sr(NO 3 ) 2 For raw materials, press P 2 o 5 -CaO-Na 2 O mole percentage 47:47:6 accurately weighed 1.669 grams of P 2 o 5 , 2.773 g Ca(NO 3 ) 2 4H 2 O, 0.256 g NaNO 3 ; Press Sr(NO 3 ) 2 %=1~5mol% Weigh 0.050~0.249 grams of Sr(NO 3 ) 2 .

[0032] (1) Preparation of P 2 o 5 Precursor solution: the weighed P 2 o 5 Slowly add 22.5ml of absolute ethanol and stir vigorously for 1~2h to form a stable transparent solution. Due to the violent reaction between phosphorus pentoxide and ethanol, a large amount of heat is released, so the P 2 o 5 When adding to ethanol, it must be added slowly in a small amount, and it must be stirred quickly to release the heat quickly.

[0033] (2) Preparation of inorganic salt solution: Measure 10ml of ethylene glycol and 15ml of ethanol solution, and weigh the Ca(NO 3 ) 2 4H 2 O, NaNO 3 , Sr(NO 3 ) 2 Ad...

Embodiment 3

[0037] Example 3: CaO-P 2 o 5 -Na 2 O-MgO glass ceramic film

[0038] with P 2 o 5 , Ca(NO 3 ) 2 4H 2 O, NaNO 3 , Mg(NO 3 ) 2 ·6H 2 O is raw material, press P 2 o 5 -CaO-Na 2 O mole percentage 47:47:6 accurately weighed 1.669 grams of P 2 o 5 , 2.773 g Ca(NO 3 ) 2 4H 2 O, 0.256 g NaNO 3 ; Press Mg(NO 3 ) 2 ·6H 2 O%=1~3mol% Weigh 0.060~0.181 grams of Mg(NO 3 ) 2 ·6H 2 O.

[0039] (1) Preparation of P 2 o 5 Precursor solution: the weighed P 2 o 5 Slowly add 22.5ml of absolute ethanol and stir vigorously for 1~2h to form a stable transparent solution. Due to the violent reaction between phosphorus pentoxide and ethanol, a large amount of heat is released, so the P 2 o 5 When adding to ethanol, it must be added slowly in a small amount, and it must be stirred quickly to release the heat quickly.

[0040] (2) Preparation of inorganic salt solution: Measure 10ml of ethylene glycol and 15ml of ethanol solution, and weigh the Ca(NO 3 ) 2 4H 2 O, NaN...

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PUM

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Abstract

The invention relates to a degraded glass ceramic thin film for a medical magnesium alloy surface and a preparation method of the degraded glass ceramic thin film. The thin film is composed of CaO-PoO5-Na2O-MO, wherein the mol ratio of Ca to P is 1, M is one or combination of more selected from Zn, Sr, Mg, Ag, Ti and Al, the mol percentage of MO is 1-5%, the CaO-PoO5-Na2O is based and the ratio of Ca to P is controlled to be equal to 1; stable gels with various components are prepared by adding one or two different metal ions; a gel layer is evenly coated on the surface of a magnesium alloy substrate by dipping-lifting, and finally, the uniform and compact glass ceramic thin film is obtained after drying and heat treatment. The glass ceramic thin film prepared by using the method not only has excellent biological activity and degradable ability, but also has a controllable degrading rate; the degrading rate can be adjusted to be matched with the growth rate of a bone tissue to be restored, and therefore, various clinical demands are met.

Description

technical field [0001] The invention relates to a preparation method of a surface coating in the technical field of medical materials, in particular to a degraded glass ceramic film on the surface of a medical magnesium alloy and a preparation method thereof. technical background [0002] In recent years, the research and development of magnesium-based biomedical materials has attracted close attention. The degradability, good biocompatibility and mechanical properties of magnesium alloys have shown good application prospects in the field of degradable biomedical materials. . Spontaneous degradation is the most prominent advantage of magnesium-based alloys as medical materials. Magnesium and its alloys have lively chemical properties. When implanted into the human body as hard tissue repair materials, they can be gradually and completely degraded by corrosion while the human tissue is gradually healing, and it is not harmful to the body. Harmful to the human body, effective...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/58
Inventor 蔡舒任萌果王雪欣叶新羽窦瑛
Owner TIANJIN UNIV
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