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Anti-microbial catheter and preparation method thereof

The technology of a urinary catheter and an antibacterial layer is applied in the field of medical equipment and its preparation, which can solve the problems of easy aggregation, high equipment requirements and high cost, and achieve the effects of delaying the release speed, increasing the antibacterial time and increasing the antibacterial dose.

Inactive Publication Date: 2013-01-23
成都盛泰尔生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary nano-metal particles are unstable and easy to aggregate, and it is more difficult to directly and evenly coat the surface of various catheters, so they are generally mixed in catheter materials, as described in Chinese invention patent 200510041228.6, but this The technical cost is high, and a large amount of silver ions mixed directly may also affect other properties of the catheter material, while the antibacterial effect of the catheter is only determined by a small amount of nano-silver coating on the surface
[0010] Another nano-silver coating method is to electroplate metal silver on the surface of the catheter or vacuum-plate silver on the metal or plastic surface. The second coating method requires high equipment and increases the cost of the process.

Method used

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  • Anti-microbial catheter and preparation method thereof
  • Anti-microbial catheter and preparation method thereof
  • Anti-microbial catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of silver nanoparticles:

[0050] Prepare nano-silver solution by using o-benzoylsulfonimide as a stabilizer and tetramethylethylenediamine as a reducing agent:

[0051] Add 10ml 0.1~0.5 mol / L AgNO 3 Mix the solution evenly, add 2ml of TMEDA (tetramethylethylenediamine) with a mass volume concentration of 1-10%, and react for 1h under stirring. Thus, a silver nano-silver solution with a cloudy yellow color was prepared. The supernatant obtained by centrifugation was yellow-brown transparent nano-silver solution.

[0052] The particle diameter distribution and particle shape of the synthesized nano-silver solution were observed by TEM, and the results are shown in the attached figure 1 The shown average particle diameter is a nano-silver solution of less than 10nm, and the shape is a spherical particle.

[0053] Nanosilver solutions were determined by UV / VIS spectroscopy. The result is as figure 2 As shown, the nano-silver solution absorption peak is ...

Embodiment 2

[0056] By using NaBH 4 Synthesize nano silver as reducing agent and stabilizer:

[0057] Add 10ml 0.1~2mmol / L NaBH into the flask 4 solution, add 10ml 0.1~2 mmol / L AgNO to it under stirring 3 , continue to stir the reaction for 20min. Thus, a yellow nano-silver solution was prepared.

[0058] Observing the particle diameter distribution and particle shape of the synthesized nano-silver solution by TEM, the results are as follows image 3 The shown average particle diameter is 12-15nm nanometer silver solution with uniform size, and the shape is spherical particle.

[0059] Nanosilver solutions were determined by UV / VIS spectroscopy. The result is as Figure 4 , The absorption peak of silver nanoparticles is 390nm.

[0060]

Embodiment 3

[0062] Preparation of polymer modified nano silver:

[0063] The nano-silver prepared in the above examples 1 and 2 can all be modified by polymer encapsulation.

[0064] In parts by weight, the obtained concentration is 100 parts of nano-silver solution of 100-300ppm, add 300 parts of ethanol, stir at 100-400 rpm for 15 minutes, adjust the pH of the solution to alkaline with ammonia water, add 1 part by weight ratio 1: 1 Mix tetraethylsilane and 3-aminopropyltriethoxysilane, continue to stir at room temperature for 18 to 24 hours, and the product is purified by high-speed centrifugation at 2000 to 10000 rpm to obtain a new type of nano Silver particles, such as Figure 5 As shown, the particle size is 100 nm. The ultraviolet absorption peak of nano-silver solution is 399nm.

[0065]

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Abstract

The invention discloses an anti-microbial catheter and a preparation method thereof and belongs to the field of medical appliances and preparation methods of the medical appliances. The anti-microbial catheter comprises a catheter and further comprises an anti-microbial layer arranged on the surface of the catheter; the anti-microbial layer is made of gathered polymer coated nano metal micro-particles; and the nano metal has anti-microbial property. The preparation method sequentially comprises the following steps of: preparing a nano metal solution, adding a polymer solution in the nano metal solution, performing nano metal polymer coating modification or preparing a nano metal-polymer complex to obtain a polymer coated nano metal micro-particle solution, attaching the polymer coated nano metal micro-particle solution on the surface of the catheter, cleaning and drying to finally obtain the anti-microbial catheter. The product provided by the invention is the anti-microbial catheter which is simple, low in cost, stable and long-acting in anti-microbial effect and controllable in effect; the preparation method disclosed by the invention is easy and convenient to implement and low in cost; and the final product is stable and long-acting in anti-microbial effect and controllable in effect.

Description

technical field [0001] The invention belongs to the field of medical equipment and its preparation method. Background technique [0002] Urinary catheters are mainly used for urinary catheterization in clinical strokes, fractures, and critically ill patients. They are one of the most commonly used medical devices in hospitals. About 25% of inpatients use urinary catheters during their stay. During use, due to various factors, it is often accompanied by catheter-induced urinary tract infection. It has been reported that CAUTI accounts for 30% of all clinical bacterial infections. With the increase of residence time, the infection rate of catheter increases. During the use of urinary catheters, the bacterial infection rate after a simple catheterization is usually about 1 to 5%, and 25% of the catheters with a retention period of more than 7 days will cause bacterial infections. If the catheterization time exceeds 14 days, urinary tract infection The incidence rate is 90-10...

Claims

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Application Information

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IPC IPC(8): A61L29/16A61L29/10A61L29/08A61M25/00
CPCA61L2300/404A61L2400/12A61L2300/102A61L29/16A61L29/085
Inventor 蔡文胜吴晓迪
Owner 成都盛泰尔生物科技有限公司
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