Production equipment of anti-infective bone graft material and preparation method

Abstract

The invention discloses production equipment of an anti-infective bone graft material and a preparation method. The equipment comprises a bone grain preheating tank, a sol tank, a vacuum-pumping package tank, an ice water tank provided with a dispersing device, a rotary vacuum drying bin, a control panel, a vacuum pump and a refrigerating compressor region. According to the invention, gelatin antibiotics and active bones in either the appearances or the inner parts of products produced by the equipment and the process are jointed tightly and uniformly, and natural holes are filled with the gelatin antibiotics. The standardization of product production is realized, and mass production can be performed at a time so as to realize large-scale production of the products; bacteriostatic experiments in vitro and animal experiments prove that significant difference exists between the products produced by the method and the original products in the aspect of anti-infective properties; and the animal experiments and clinical applications prove that the bone repairing ability of the products produced by the new method is better than that of the products produced by the original method.

Description

technical field [0001] The invention belongs to the technical field of bone graft materials, and relates to the preparation of an anti-infection bone graft material, in particular to a preparation method and equipment for an anti-infection bone graft material using gelatin as an antibiotic slow-release agent. Background technique [0002] The treatment of contaminated and infectious bone and joint injuries has always been a problem that has not been well resolved in the field of orthopedics. Traditional treatment methods first use debridement and other surgical methods to remove most of the pathogenic bacteria, and then use antibiotics to eliminate the remaining pathogenic bacteria and wait for the wound to be closed. After the infection is controlled, 3-6 months are followed by the second-stage bone graft repair. In principle, stage I bone grafting is contraindicated, because after debridement of infected / contaminated bone defects, some pathogenic bacteria remain, and these...

AI Technical Summary

Problems solved by technology

[0003] The existing technology is essentially a laboratory-level product production process, with a high degree of manual work, and human factors have a great influence on the performance of the product, making it difficult to produce standardized and homogenized products. The bone particles wrapped in this method The size is different, some have too much gelatin, and some granules have less gelatin; the large-scale production of the product cannot be realized. With this method of production, the bone particles need to be manually added to the mold, and the addition of the gelatin solution is also a manual operation. Time-consuming, inefficient, it is difficult to sterilize the mold before and after use, and it is also very difficult to take out the solidified product from the mold; , the active bone particles are located at the bottom of the mold, the gelatin cannot completely wrap the bone particles, and the bottom bone particles are exposed. After the temperature is lowered and gradually dried, some bone particles are often separated from the gelatin due to the shrinkage of the gelatin; in addition, Because of the special properties of gelatin and the special temperature requirements of the active bone to be wrapped, it is difficult to use freeze-drying technology and baking methods for this product. Its drying basically depends on natural drying, and the ambient humidity has a great influence on its drying. ; Moreover, the products produced by means of existing molds are only coated with a layer of gelatin antibiotics on the outer surface of the bone grains, and the gelatin antibiotics are difficult to enter in the natural pore structure of the bone grains; at the same time, it has been found in clinical applications that the bone repair function of the bone grains must be It cannot work until the gelatin layer wrapped by its outer layer is completely dissolved, that is, the current production process delays bone repair

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