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2-hydroxy-N-(2-hydroxybenzoyl) benzo-hydrazide dibutyl tin complex and preparation method and application thereof

A technology of dibutyltin benzohydrazide and hydroxybenzoyl, which is applied in the field of dibutyltin complexes, can solve the problems of biological activity that has not been reported in the literature, and achieve the effects of low cost, high anticancer activity and simple preparation method

Inactive Publication Date: 2013-01-30
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The complex and biological activity of 2-hydroxy-N-(2-hydroxybenzoyl)benzohydrazide and dibutyltin chloride in this patent have not been reported in the literature

Method used

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  • 2-hydroxy-N-(2-hydroxybenzoyl) benzo-hydrazide dibutyl tin complex and preparation method and application thereof
  • 2-hydroxy-N-(2-hydroxybenzoyl) benzo-hydrazide dibutyl tin complex and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0019] Dissolve 1.0 mmol 2-hydroxy-N-(2-hydroxybenzoyl)benzohydrazide in 20ml CH 3 OH, then slowly drop 1.0 mmol (Bu) into the solution 4 NH 4 OH (25% aqueous solution), after stirring at room temperature for 0.5 h, 2.0 mmol Bu 2 SnCl 2 Added to the above mixed solution, and continued to stir at room temperature for 18h. After filtration, the filtrate was left standing at room temperature, and the color gradually changed from colorless to red. One month later, red blocky crystals were obtained at 281-283°C. The compound yield was 70.0%.

[0020] Organotin compound of the present invention is through infrared spectrum analysis and nuclear magnetic resonance and X-single crystal diffraction analysis, and result is as follows:

[0021] IR (KBr, cm -1 ): υ = 1637.5 (C=O), 1601.6 (C=N-N=C), 544.5 (Sn-O), 460 (Sn-N).

[0022] Crystallographic data: The compound belongs to the monoclinic crystal system, the space group is P2(1) / c, and the unit cell parameters are: a = 8.8810(...

Embodiment 2

[0024] Dissolve 1.0 mmol 2-hydroxy-N-(2-hydroxybenzoyl)benzohydrazide in 20ml CH 3 OH, and then slowly drop 0.5 mmol (Bu) into the solution 4 NH 4 OH (25% aqueous solution), after stirring at room temperature for 0.5 h, 2.0 mmol Bu 2 SnCl 2 Added to the above mixed solution, and continued to stir at room temperature for 18h. After filtration, the filtrate was left standing at room temperature, and the color gradually changed from colorless to red. One month later, red blocky crystals were obtained at 281-283°C. The compound yield was 52.6%.

Embodiment 3

[0026] Dissolve 1.0 mmol 2-hydroxy-N-(2-hydroxybenzoyl)benzohydrazide in 20ml CH 3 OH, and then slowly drop 1.5 mmol (Bu) into the solution 4 NH 4 OH (25% aqueous solution), after stirring at room temperature for 0.5 h, 2.0 mmol Bu 2 SnCl 2Added to the above mixed solution, and continued to stir at room temperature for 18h. After filtration, the filtrate was left standing at room temperature, and the color gradually changed from colorless to red. One month later, red blocky crystals were obtained at 281-283°C. The compound yield was 66.3%.

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Abstract

The invention discloses a 2-hydroxy-N-(2-hydroxybenzoyl) benzo-hydrazide dibutyl tin complex which has higher antitumor activity so as to be taken as raw material to prepare medicines for treating mice chronic myeloid leukemia and cervical cancer; and compared with the existing commonly used platinum anticancer medicines, the organic tin complex has the characteristics of higher antitumor activity, good lipid solubility, low cost, simple preparation method and the like.

Description

Technical field [0001] The present invention involves a two-binjin parts of the 2-hydroxyl-N- (2-hydroxyl benzol) benzene and the method of preparation methods, as well as the application of the compound in anticancer drugs. Background technique [0002] Organic tin compounds refer to metal organic compounds that contain at least one tin-car-car (SN-C).With the development and application of single crystal X-ray diffraction technology, the research of organic tin chemistry has gained unprecedented prosperity.In this area, a large number of research papers are published every year; the scope of research has continued to expand, covering many disciplines such as organic chemistry, controlling chemistry, structural chemistry, and biochemistry, and has become an important frontier research field.Especially since the 1980s, the synthesis of organic tin compounds and the application research in the field of pharmacy has made it a promising research direction.In 1980, chemists such as C...

Claims

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Application Information

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IPC IPC(8): C07F7/22A61K31/60A61P35/00A61P35/02A61P15/00
Inventor 李士栋李大成窦建民
Owner LIAOCHENG UNIV
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