Simple determination method of 90Sr content in 89Sr sample

A measurement method, 89sr technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of economical detection consumables and simple measurement methods

Inactive Publication Date: 2013-02-06
SHANGHAI ATOM KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the sample 89 Sr with 90 The difference in the amount of Sr reaches 10 -6 , and both are β

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A sort of 89 In the Sr sample 90 A simple assay method for Sr content, the method may further comprise the steps:

[0018] (1) Cut the Xinhua 1# filter paper into strips with a width of 25 mm and a length of 300 mm, and soak them in 1.5 mol / L di-(2-ethylhexyl) phosphoric acid D2EHPA / toluene solution. Take out after soaking, dry and set aside;

[0019] (2) Adjust with 0.5mol / l HCL 89 pH of the Sr sample to 3.0;

[0020] (3) Add the sample with adjusted pH value to the lower end of the filter paper to be used with a pipette, hang it in 0.1mol / L HNO after drying 3 Unfold in middle; take out when ascending 14mm*15mm, dry;

[0021] (4) Cut paper strips with a width of 15mm in each section, measure its activity section by section with an activity meter, record the measurement data and measurement time, to determine the preliminary situation of the separation of strontium and yttrium;

[0022] (5) Take a piece of paper at the origin point, put it in a scintillation vial,...

Embodiment 2

[0025] A sort of 89 In the Sr sample 90 A simple assay method for Sr content, the method may further comprise the steps:

[0026] (1) Cut the Xinhua 1# filter paper into strips with a width of 25mm and a length of 300mm, and soak them in 1mol / L di-(2-ethylhexyl)phosphoric acid D2EHPA / toluene solution. Take out after soaking, dry and set aside;

[0027] (2) Adjust with 0.4mol / L HCL 89 pH of the Sr sample to 3.0;

[0028] (3) Add the sample with adjusted pH value to the lower end of the filter paper to be used with a pipette, hang it in 0.1mol / L HNO after drying 3 Unfold in middle; take out when ascending 14mm*15mm, dry;

[0029] (4) Cut paper strips with a width of 15mm in each section, measure its activity section by section with an activity meter, record the measurement data and measurement time, to determine the preliminary situation of the separation of strontium and yttrium;

[0030] (5) Take a piece of paper at the origin point, put it in a scintillation vial, add 1...

Embodiment 3

[0033] A sort of 89 In the Sr sample 90 A simple assay method for Sr content, the method may further comprise the steps:

[0034] (1) Cut Xinhua 1# filter paper into paper strips with a width of 25mm and a length of 300mm, soak in 2mol / L di-(2-ethylhexyl)phosphoric acid D2EHPA / toluene solution, take out after soaking, dry and set aside;

[0035] (2) Adjust with 0.6mol / L HCL 89 pH of the Sr sample to 3.0;

[0036] (3) Add the sample with adjusted pH value to the lower end of the filter paper to be used with a pipette, hang it in 0.2mol / L HNO after drying 3 Unfold in middle; take out when ascending 14mm*15mm, dry;

[0037] (4) Cut paper strips with a width of 15mm in each section, measure its activity section by section with an activity meter, record the measurement data and measurement time, to determine the preliminary situation of the separation of strontium and yttrium;

[0038] (5) Take a piece of paper at the origin point, put it in a scintillation vial, add 10mL of d...

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PUM

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Abstract

The invention relates to a simple determination method of 90Sr content in an 89Sr sample. The method comprises the following steps of: taking D2EHPA (di(2-ethyl hexyl)phosphoric acid)/methylbenzene solution as an extracting agent, and HNO3 solution as a developing agent; separating the 89Sr sample by a paper chromatography, and then determining accurate content of the 90Y and 90Sr by measuring the half-life period of an origin paper segment, so as to determine the 90Sr content in the 89Sr sample, wherein the 90Y is a decay daughter of 90Sr. Compared with the prior art, the simple determination method has the advantages of being simple, convenient, economical, effective and the like.

Description

technical field [0001] The present invention relates to a kind of determination method of isotope, especially relate to a kind of 89 In the Sr sample 90 A simple method for the determination of Sr content. Background technique [0002] 89 Sr is an osteophilic nuclide, and the application of strontium chloride in the treatment of bone pain caused by metastatic malignant diseases has the advantages of small side effects, good effect in relieving bone pain, long pain relief time, and repeated injections after three months. Therefore, In recent years, it has been widely used in clinical [0003] 89 Sr is produced by reactors, which simultaneously produce highly toxic nuclides 90 Sr. According to the Pharmacopoeia, in 89 Sr sample half-life 90 Sr content should be less than 2.3*10 -4 %. Due to the sample 89 Sr with 90 The difference in the amount of Sr reaches 10 -6 , and both are β - Decay, difficult to determine by methods such as separation or direct measurement ...

Claims

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Application Information

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IPC IPC(8): G01N23/00
Inventor 张蕾
Owner SHANGHAI ATOM KEXING PHARMA
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