Preparation method for Shuanghuanglian granules

A technology of shuanghuanglian and granules, applied in the field of preparation of shuanghuanglian granules, can solve the problems of long production cycle, low production capacity, and many workers, and achieve the effect of reducing labor intensity and avoiding environmental damage.

Active Publication Date: 2013-02-20
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve one or more problems of the existing Shuanghuanglian granule preparation method, such as complex preparation method, low production capacity, long production cycle, large number of workers, various types of equipment, and huge occupied production site, and to provide a Preparation method of Shuanghuanglian granules

Method used

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  • Preparation method for Shuanghuanglian granules
  • Preparation method for Shuanghuanglian granules
  • Preparation method for Shuanghuanglian granules

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specific Embodiment approach 1

[0013] Specific embodiment one: the preparation method of a kind of Shuanghuanglian granules of the present embodiment is carried out according to the following steps: take the wet paste of Scutellaria baicalensis extract, add 2.5 to 4 times the weight of water and mix it evenly, and then adjust it with sodium hydroxide solution. When the pH value reaches 7.0, stir to dissolve, add honeysuckle and forsythia mixed extract paste according to the prescription amount, then concentrate to a clear paste with a relative density of 1.09~1.12, let cool to 50°C, filter, collect the filtrate as a binder, and add auxiliary materials , boiled, dried and granulated to obtain Shuanghuanglian granules.

[0014] The relative density of the clear paste in this embodiment is the density relative to water at a temperature of 75°C to 85°C.

[0015] The Scutellaria baicalensis extract wet ointment and the mixed extract ointment of honeysuckle and forsythia described in this embodiment are prepared ...

specific Embodiment approach 2

[0023] Embodiment 2: This embodiment differs from Embodiment 1 in that: the pH range is 6.5-7.5. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0024] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the relative density is measured at a temperature of 75°C to 85°C. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method for Shuanghuanglian granules. The invention aims at providing a preparation method for solving one or a plurality of problems of an existing preparation method for the Shuanghuanglian granules that the preparation method is complex, the product output is low, the production period is longer, a large number of workers are needed, various devices are adopted, and a grand site is occupied for production. The preparation method comprises the following steps: getting scutellaria baicalensis extractive cream type paste; adding proper water to uniformly mix; adjusting pH (Potential of Hydrogen) to reach neutral by sodium hydroxide solution; agitating to dissolve; adding honeysuckle and fructus forsythiae based on the dose prescribed in the prescription; mixing and extracting the paste; then heating and concentrating into liquid type paste; filtering; collecting the filtrate to be used as adhesive; adding proper auxiliary materials such as cane sugar and dextrin; and then implementing fluidized dry granulating, so as to obtain the finished product. The preparation method adopts the one-step granulating (fluidized dry granulating) manner, so that the time, labor and force are saved, the working strength is reduced, and the cross contamination between the environment and the medicine can be completely avoided. The preparation method is applied to the field of traditional Chinese medicines.

Description

technical field [0001] The invention relates to a preparation method of Shuanghuanglian granules. Background technique [0002] Shuanghuanglian Granules is recorded in the current Chinese Pharmacopoeia 2010 Edition. It is an over-the-counter medicine for colds. For colds caused by exogenous wind-heat. The preparation method comprises the following steps: the extract of scutellaria baicalensis and the extract of honeysuckle and forsythia are separately dried under reduced pressure, the dry extract is pulverized, mixed, wet granulated, dried and granulated. This method is very backward after the upgrading of pharmaceutical equipment. In addition to the long production cycle and the large number of workers used, the labor intensity of the workers is high, the production capacity is also low, and there are various types of equipment used, which occupies a huge production site. (For details, please refer to the process time-consuming table before and after the change), which is...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/16A61P11/00
Inventor 李文春崔仁海李长新解黎雯苏德龙裴福成单钰毓李殿明王英新
Owner 哈药集团中药有限公司
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