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Method for preparing anti-viral oral liquid and product thereof

An antiviral oral liquid and oral liquid technology, which is applied in the field of preparation of improved antiviral oral liquid, can solve problems such as unstable efficacy and quality, poor pH value stability, and affecting product appearance

Active Publication Date: 2013-02-27
HANGZHOU L TONJUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing commercially available products are analyzed and researched, and the results show that the products produced according to current standards have the following problems: 1, the preparation method of the existing antiviral oral liquid is not perfect, and the given range of pH value is too large, resulting in the product 2. The stability of the pH value is poor; the existing sugar-containing antiviral oral liquid, after being placed for 3 months, the pH value of the sample presents a significant downward trend, and the forsythin content drops by more than 10%; Precipitation occurred in the solution after standing for one year
If the clarity decreases, it will turn into a turbid brown solution, which will affect the appearance of the product; while the content of forsythin directly affects the efficacy of the antiviral oral liquid, the obvious decrease in the content of forsythin means that the efficacy of the antiviral oral liquid will not last for a long time. After setting, it will also drop significantly
Therefore, the existing antiviral oral liquid has the problems of unstable efficacy and quality, and easily causing disputes between doctors and patients.

Method used

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  • Method for preparing anti-viral oral liquid and product thereof

Examples

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Effect test

Embodiment 1

[0025] The invention relates to a preparation method of an antiviral oral liquid. The preparation method comprises adding sodium dihydrogen phosphate buffer salt into the solution, and adjusting the pH so that the pH value of the finished oral liquid is stabilized at 5.5.

[0026] The specific preparation method of the above-mentioned antiviral oral liquid is: weigh 129g of Radix Radix, 57g of Gypsum, 61g of Reed Root, 32g of Rehmannia, 25g of Curcuma, 25g of Anemarrhena, 25g of Shichangpu, 29g of Patchouli, 46g of Forsythia nine herbs , add water and decoct twice; decoct for 1.5 hours for the first time, 1 hour and 20 minutes for the second time, filter, combine the filtrates, concentrate to 200ml, add 95% ethanol to make the alcohol content 70%, let stand , filtered, the filtrate recovered ethanol and concentrated to an appropriate amount, added volatile oil, volatile oil emulsion, antibacterial agent, corrective agent in an appropriate amount; then added 5 g of sodium dihydr...

Embodiment 2

[0029] The invention discloses a preparation method of an antiviral oral liquid. The preparation method comprises adding potassium dihydrogen phosphate buffer salt and adjusting the pH so that the pH value of the oral liquid is stabilized at 6.0.

[0030] The specific preparation method of the above-mentioned antiviral oral liquid is: weigh 129g of Radix Radix, 57g of Gypsum, 61g of Reed Root, 32g of Rehmannia, 25g of Curcuma, 25g of Anemarrhena, 25g of Shichangpu, 29g of Patchouli, 46g of Forsythia nine herbs , add water and decoct twice; decoct for 1.5 hours for the first time, 1 hour and 20 minutes for the second time, filter, combine the filtrates, concentrate to 200ml, add 95% ethanol to make the alcohol content 70%, let stand , filtered, the filtrate recovered ethanol and concentrated to an appropriate amount, added volatile oil, volatile oil emulsion, antibacterial agent, corrective agent in an appropriate amount; added 8 g of potassium dihydrogen phosphate buffer salt; ...

Embodiment 3

[0033] The invention discloses a preparation method of an antiviral oral liquid. The preparation method comprises adding potassium dihydrogen phosphate buffer salt and adjusting the pH so that the pH value of the oral liquid is stabilized at 5.8.

[0034] The specific preparation method of the above-mentioned antiviral oral liquid is: weigh 129g of Radix Radix, 57g of Gypsum, 61g of Reed Root, 32g of Rehmannia, 25g of Curcuma, 25g of Anemarrhena, 25g of Shichangpu, 29g of Patchouli, 46g of Forsythia nine herbs , add water and decoct twice; decoct for 1.5 hours for the first time, 1 hour and 20 minutes for the second time, filter, combine the filtrates, concentrate to 200ml, add 95% ethanol to make the alcohol content 70%, let stand , filtered, the filtrate recovered ethanol and concentrated to an appropriate amount, added volatile oil, volatile oil emulsion, antibacterial agent, corrective agent in an appropriate amount; added 5 g of potassium dihydrogen phosphate buffer salt; ...

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Abstract

The invention discloses a method for preparing anti-viral oral liquid and a product thereof. The method is characterized in that the pH value of the oral liquid is stabilized at 5.5 to 6; and preferably, the pH value is stabilized in the range by adding a buffer salt. The preparation method for the product is completed, and the effect of the product is improved; and the clarity of the oral liquid can be effectively kept for a long term, and the pH value of the oral liquid and the stability of the forsythin content are effectively improved.

Description

technical field [0001] The invention relates to a method for preparing an improved antiviral oral liquid and a product thereof, belonging to the field of medicine. Background technique [0002] Antiviral oral liquid is a traditional Chinese medicine preparation widely used in the market, and it is mainly used clinically for the treatment of wind-heat cold and flu. The prescription process of antiviral oral liquid in Pharmacopoeia is as follows: [0003] 【Prescription】Isatis root 129g, gypsum 57g, reed root 61g, rehmannia 32g, turmeric 25g, Anemarrhena 25g, Shichangpu 25g, patchouli 29g, forsythia 46g; [0004] [Preparation method] The above nine flavors are decocted twice with water, the first time is 3 hours, the volatile oil is collected, and encapsulated with hydroxypropyl beta-cyclodextrin, or the first time is 1.5 hours (collecting volatile oil and volatile oil emulsion at the same time ); 1 hour and 20 minutes for the second time, filter, combine the filtrates, conce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/08A61K47/02A61P31/12A61K33/06
Inventor 黄安琪潘沁
Owner HANGZHOU L TONJUN PHARMA
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