Manufacture method for three-dimensional micro-fluidic chip
A technology of microfluidic chips and manufacturing methods, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of unfavorable large-scale production, low production efficiency, complicated preparation steps, etc., and achieve easy Industrialized large-scale production, high production efficiency and low processing cost
Inactive Publication Date: 2014-08-20
ZHEJIANG UNIV
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Problems solved by technology
This technical solution uses traditional photolithography, hot pressing and other methods to produce a substrate with micro-nano-sized flow channels on one side, and then bonds it to the cover sheet to form a three-dimensional micro-channel. The preparation steps are complicated and the process is difficult. It is cumbersome and has low production efficiency, which is not conducive to large-scale industrial production
Method used
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Embodiment 1
[0054] 1) First pour a layer of liquid mixture of polydimethylsiloxane and curing agent with a mass ratio of 10:1 on the work surface, with a thickness of 1mm, and form the bottom surface of the chip after it is cured;
[0055] 2) Spray solvent-soluble flow channel solid material on the bottom surface of the chip to prepare a three-dimensional flow channel solid structure, including:
[0056] a) First use CAD software (Solidworks) to design a three-dimensional flow channel, the three-dimensional flow channel diagram is as follows image 3 As shown, wherein, the flow channel inlet 31, the flow channel inlet 32 and the flow channel outlet 33 are respectively located on both sides of the three-dimensional flow channel;
[0057] b) Use commercial MasterCAM software to slice the three-dimensional flow channel in the three-dimensional flow channel diagram along the direction parallel to the bottom surface of the chip (that is, the plane where the X and Y directions of the three-ax...
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Abstract
The invention discloses a manufacture method for a three-dimensional micro-fluidic chip. The manufacture method comprises the following steps of: 1), casting a layer of liquid curable resin on a work surface, so as to form the bottom surface of the chip after curing; 2), spraying a runner solid material which can be dissolved to the solvent on the bottom surface of the chip to prepare a three-dimensional runner solid structure; 3), casting liquid curable resin on the three-dimensional runner solid structure, covering the three-dimensional runner solid structure, and curing to form the solid chip; 4), dissolving the three-dimensional runner solid structure in the solid chip by adopting solvent to acquire the three-dimensional micro-fluidic chip. The manufacture process is simple, the three-dimensional structure is precisely controllable and the manufacturing efficiency is high. The invention further discloses a three-axis machine tool which is improved on the basis of the conventional three-axis machine tool. A spindle shaft is changed to be a spray head, and the spray head is controlled by an XYZ-axis motion assembly of the three-axis machine tool to spray the runner solid material which can be dissolved to the solvent to form sections S1-Sn in sequences, so that a three-dimensional runner solid structure is acquired.
Description
technical field [0001] The invention relates to the field of micro-nano processing, in particular to a method for manufacturing a three-dimensional microfluidic chip. Background technique [0002] Microfluidics integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into one chip to automatically complete the analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] The main characteristic of microfluidic chips is that their effective structures (channels, reaction chambers, and certain other functional components) containing fluids are micron-scale in at least one latitude. Due to the micron-scale structure, the fluid exhibits and produces special properties different from those in the ...
Claims
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IPC IPC(8): B01L3/00
Inventor 贺永夏冰傅建中金育安
Owner ZHEJIANG UNIV