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An ophthalmic preparation containing oxygen microcapsules and its preparation method

An ophthalmic preparation and oxygen technology, applied in the field of corneal injury, can solve the problems of no precedents and reports of corneal oxygen supply, and achieve the effects of improving corneal hypoxia, accelerating treatment, and preventing corneal injury.

Active Publication Date: 2016-01-20
李洪江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] But so far, there are no precedents and reports of supplying oxygen to the cornea through oxygen microcapsules at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0027] The invention relates to an ophthalmic preparation containing oxygen microcapsules. The preparation contains a large number of oxygen microcapsules, and oxygen is also saturated and dissolved in the liquid. When instilled into the eye, there is sufficient oxygen in contact with the cornea, which can be absorbed and utilized by the cornea to maintain its normal physiological functions. Contact lens wearers will cause corneal edema and turbidity due to reduced corneal contact with oxygen. The present invention can solve this kind of corneal hypoxia problem.

[0028] The present invention can also be instilled through the outer eye, so that oxygen molecules enter the vitreous body through the outer eye, thereby supplying oxygen to the retina, improving the state of fundus hypoxia in diabetic patients, and inhibiting the expression of hypoxia-inducible factor-1α (HIF-1α). Inhibit the expression of vascular endothelial growth factor (VEGF), prevent the formation of diabetic ...

Embodiment 1

[0035] prescription:

[0036] 30% oxygen 500ml

[0037] Poloxamer 20.0g

[0038] Soy Lecithin 12.0g

[0039] Glycerin 12.5g

[0040] Carbomer 2.0g

[0041] Sodium hydroxide solution to adjust the pH to 7.2

[0042] water balance

[0043] Makes 1000ml.

[0044]Preparation method: Take the prescribed amount of carbomer and soak in water for 12 hours; take another glycerin, poloxamer, soybean lecithin and disperse evenly in water, combine with the carbomer solution, add water to 500ml, stir evenly, wash with sodium hydroxide The pH of the solution was adjusted to 7.3, and filtered with a 200-mesh stainless steel mesh. Adjust medical oxygen to a concentration of 30% oxygen content, pass it into the above solution, and stir at high speed while ventilating, so that the solution forms small microcapsules containing a large amount of oxygen, the volume is up to 1000ml, and then use a high-pressure homogenizer Homogenize to form stable oxygen microcapsules, pack into plastic ey...

Embodiment 2

[0046] prescription:

[0047] 45% oxygen 300ml

[0048] Poloxamer 15.0g

[0049] Soy Lecithin 12.0g

[0050] Sodium chloride 4.9g

[0051] Carbomer 2.0g

[0052] Sodium hydroxide solution to adjust the pH to 7.7

[0053] water 700ml

[0054] Makes 1000ml.

[0055] Preparation method: Take the prescribed amount of carbomer and soak in water for 12 hours, take another sodium chloride, poloxamer, soybean lecithin to dissolve and evenly disperse in water, combine with carbomer solution, add water to 700ml, stir evenly, Adjust the pH to 7.4 with sodium hydroxide solution, filter through a 200-mesh stainless steel mesh, sterilize at 121°C for 30 minutes, and cool to room temperature. Adjust medical oxygen to a concentration of 45% oxygen, pass through a 0.22μm microporous membrane, pass it into the above solution, and stir at high speed while ventilating, so that the solution forms small microcapsules containing a large amount of oxygen, with a volume of up to 1000ml Then us...

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Abstract

The invention relates to the field of ophthalmic preparations containing oxygen microcapsules, which are mainly used to prevent and treat various eye diseases caused by hypoxia, and are especially suitable for corneal damage. It is characterized in that: the preparation is a flowing semi-solid gel preparation, and the preparation is composed of the following components: oxygen accounts for 5-70% of the total volume of the preparation, and the oxygen concentration is 5-100%; the surfactant accounts for the total volume of the preparation. 0.1-50% by weight, the isotonic regulator accounts for 0.1-2.5% of the total weight of the preparation, the thickener accounts for 0.1-40% of the total weight of the preparation, and the pH regulator adjusts the pH value of the preparation to 6.8-8.6, The balance is water. The purpose of the present invention is that the cornea is damaged and the amount of oxygen contacted by the cornea is reduced due to wearing contact lenses, which will cause corneal edema and turbidity. The present invention supplies oxygen to the eye through oxygen microcapsules to solve the problem of corneal hypoxia.

Description

technical field [0001] The invention relates to the field of ophthalmic preparations containing oxygen microcapsules, which are mainly used to prevent and treat various eye diseases caused by hypoxia, and are especially suitable for corneal damage. Background technique [0002] The cornea is the most transparent part of the eye, covering the iris, pupil and anterior chamber, and provides most of the refractive power of the eye. Coupled with the refractive power of the lens, the light can be accurately focused on the retina to form an image. [0003] The cornea has very sensitive nerve endings. If a foreign object touches the cornea, the eyelids will involuntarily close to protect the eyes. Since the cornea has no blood vessels, in order to maintain transparency, it obtains nutrients and oxygen through tears and aqueous humor. [0004] The cornea is divided into five layers, from front to back: epithelial cell layer (epithelium), anterior elastic layer (lamina elastica ante...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K9/06A61K47/38A61K47/36A61K47/32A61K47/34A61P27/02
Inventor 李洪江才凤李双
Owner 李洪江