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Scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof

A technology of Qinbahong and mixture, which is applied in the field of medicine, can solve the problems of undisclosed dosage of extract, undisclosed optimal ratio, and failure to fully exert the best curative effect, etc.

Active Publication Date: 2013-03-20
黑龙江比福金北药制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. Not giving full play to the best curative effect of the proven prescription composed of Manshanhong, Baomazipi, and Scutellaria baicalensis;
[0008] 2. The alcohol precipitation process of Manshanhong and Baomazipi is unreasonable;
[0009] 3. The low-temperature refrigeration steps are unreasonable;
[0010] 4. The optimal ratio of raw materials of Manshanhong, Baomazipi, and Scutellaria baicalensis has not been made public;
[0011] 5. The dosage of extract (extract) is not disclosed;
[0012] 6. It is necessary to add ethanol to inhibit bacteria, and the cost is relatively high

Method used

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  • Scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof
  • Scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof
  • Scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Prescription Manshanhong 42kg, Baomazipi 42kg, Scutellaria baicalensis 20kg, sucrose 14kg, cyclamate 0.4kg, Tween-80 1kg, essence 0.1kg, sodium benzoate 0.24kg.

[0087] The preparation method is to crush the Mangosaurus, extract the volatile oil until it is exhausted, and collect 0.02kg of the volatile oil from the distilled Mangosteen in another device, and set aside; add 2 times the amount of water to the dregs and decoct twice, each time for 2 hours, filter and combine Concentrate the filtrate into a liquid extract, stir, and slowly add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, and take the supernatant; The supernatant is combined with the above supernatant, the ethanol is recovered, concentrated into Manshanhongliu extract, and set aside;

[0088] The skin of Baomazi is broken, add 6 times the amount of water, decoct three times for 2 hours, 1 hour, and 1 hour respectively, filter, combine the filtrate, condense into a liquid extract...

Embodiment 2

[0092] Prescription Manshanhong 43kg, Baomazipi 43kg, Scutellaria baicalensis 19kg, sucrose 14kg, sucralose 25g, Tween-80 1kg, essence 0.1kg, potassium sorbate 50g.

[0093] The preparation method is to crush and break the mangosteen, extract the volatile oil until it is exhausted, and collect 0.05kg of the volatile oil of the distilled mangosteen in another device, and set aside; add 2 times the amount of water to the dregs and decoct twice, each time for 2 hours, filter and combine Concentrate the filtrate into a liquid extract, stir, and slowly add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, and take the supernatant; The supernatant is combined with the above supernatant, the ethanol is recovered, concentrated into Manshanhongliu extract, and set aside;

[0094] The skin of Baomazi is broken, add 6 times the amount of water, decoct three times for 2 hours, 1 hour, and 1 hour respectively, filter, combine the filtrate, condense into a liquid ext...

Embodiment 3

[0098] Prescription Manshanhong 42kg, Paomazipi 42kg, Scutellaria baicalensis 20kg, sucrose 14kg, aspartame 0.2kg, Tween-80 1kg, essence 0.1kg, potassium sorbate 100g.

[0099] The preparation method is to crush and break the Mangospermum, extract the volatile oil until it is exhausted, and collect 0.03kg of the volatile oil of Mangosteen from the distillation in another device, and set aside; add 2 times the amount of water to the dregs and decoct twice, each time for 2 hours, filter and combine Concentrate the filtrate into a liquid extract, stir, and slowly add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, and take the supernatant; The supernatant is combined with the above supernatant, the ethanol is recovered, concentrated into Manshanhongliu extract, and set aside;

[0100] The skin of Baomazi is broken, add 6 times the amount of water, decoct three times for 2 hours, 1 hour, and 1 hour respectively, filter, combine the filtrate, condense into...

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Abstract

The invention relates to a scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture, which is prepared from active components, additives and water. The preparation method comprises the following steps of performing water extraction and alcohol precipitation on raw materials dahurian rhododendron leaf, manchurian lilac bark and scutellaria baicalensis; combining the dahurian rhododendron leaf alcohol precipitation extract and the manchurian lilac bark alcohol precipitation extract; refrigerating at low temperature; and adding the additives, wherein the alcohol precipitation step is performed before the combining step, and the low-temperature refrigerating step is performed before the additive adding step. The scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture has the beneficial effects that an optimal proportion of scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf is disclosed by adopting the optimal alcohol precipitation process of dahurian rhododendron leaf and manchurian lilac bark and the low-temperature refrigeration step, and ethanol is not required to be added in the whole prescription for inhibiting bacteria, so that the best curative effects of an empirical formula formed by dahurian rhododendron leaf, manchurian lilac bark and scutellaria baicalensis is sufficiently played. The effective rate of the cough-arresting mixture to acute attack of chronic bronchitis is 97.93 percent along with remarkable curative effect and low side effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a Qinbaohong cough mixture and a preparation method thereof. Background technique [0002] In the field of traditional Chinese medicine, a mixture refers to a liquid preparation for oral administration made by extracting, purifying, and concentrating medicinal materials with water or other solvents by appropriate methods (single-dose filling can also be called "oral liquid"). Qin Baohong Zhike Mixture is derived from the proven prescription of three traditional Chinese medicine raw materials, Manshanhong, Baomazipi, and Scutellaria baicalensis. It is an excellent Chinese patent medicine for clearing away heat and reducing phlegm, relieving cough and asthma. Qinbaohong Zhike Mixture was obtained by the applicant in 1999 with the drug approval number (Z19991046) issued by the Chinese drug administration department. It is a confidential product, and its prescription and productio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61K9/00A61P11/14A61P11/06A61P11/10A61K36/45A61K36/539
CPCY02A50/30
Inventor 邹晓征姜培恒
Owner 黑龙江比福金北药制药有限公司
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