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Method for detecting chrysophanol content in semen cassiae formula granules

A technology of formula granules and chrysophanol, which is applied in the field of medicine, can solve problems such as the difficulty in accurately determining the real content of chrysophanol compounds, and achieve the effects of bright color, reduced production energy consumption, and high content of active ingredients

Active Publication Date: 2014-12-17
GUANGDONG YIFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem that the above method is difficult to accurately measure the real content of chrysophanol compounds in cassia seed formula granules, the purpose of the present invention is to provide a fast, simple and accurate method for detecting the content of chrysophanol in cassia seed formula granules, so as to effectively control the content of cassia seed formula granules quality, to ensure the effectiveness and stability of the product

Method used

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  • Method for detecting chrysophanol content in semen cassiae formula granules
  • Method for detecting chrysophanol content in semen cassiae formula granules
  • Method for detecting chrysophanol content in semen cassiae formula granules

Examples

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Effect test

Embodiment 1

[0055] Example 1: Determination of the detection method of chrysophanol content in cassia seed formula granules

[0056] 1) Preparation method of cassia seed formula granules:

[0057] Put 1000g of cassia seed decoction pieces into a suitable extraction container, add 12L of drinking water, heat and extract for 2 hours, filter through a 200-mesh sieve, and store the filtrate separately; add 7L of drinking water to the dregs, heat and extract for 1 hour, filter through 350-mesh, Discard the dregs; combine the extracts and transfer to a vacuum concentrator to concentrate under reduced pressure. The vacuum degree is set to -0.1MPa, the concentration temperature is 75°C, and the concentration is stopped when the density is 1.04. The thick paste is filtered with a 350-mesh sieve. Afterwards, spray drying is adopted, the air inlet temperature is set to 175°C, and the air outlet temperature is set to 95°C, the paste powder is collected, and appropriate amount of auxiliary materials...

Embodiment 2

[0077] Example 2: Determination of the content of different batches of cassia seed formula granules

[0078] Get the cassia seed formula granules of different batch numbers, measure according to the content assay method of the chrysophanol of embodiment 1, measure its result as shown in table 8 below:

[0079] Table 8

[0080]

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Abstract

The invention discloses a method for detecting the chrysophanol content in semen cassiae formula granules. The method comprises the following steps of: measuring by using a high performance liquid chromatography; taking an appropriate quantity of semen cassiae formula granules; adding diluted hydrochloric acid of 80-120 times in quantity; putting in water bath of 60-100 DEG C; heating and hydrolyzing for 1-2 hours; taking out and cooling; transferring the hydrolysis liquid into a separating funnel; adding an equal quantity of dichloromethane to be extracted so as to separate a dichloromethane layer; repeating for 3-5 times; combining the dichloromethane extract liquor; evaporating in low temperature; dissolving the residue by using a dichloromethane and methyl mixed solution in a volume ratio of 1:1; determining the volume, filtering and taking the subsequent filtrate; respectively absorbing 10 micro-liters of reference substance solutions and test solutions precisely; measuring in accordance with chromatographic conditions; and calculating in accordance with an external standard method so as to obtain the chrysophanol content. The method provided by the invention is high in sensitivity and has good separation degree, the real content of the chrysophanol in the semen cassiae formula granules is reflected to the maximum extent, the introduction of system errors is reduced, and the accuracy and the reproducibility of measured values are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for detecting the content of chrysophanol in cassia seed formula granules. Background technique [0002] Semen Cassiae is one of the homologous varieties of medicine and food announced by the Ministry of Health. It has the effects of clearing the liver, improving eyesight, moistening the intestines and laxative. Modern pharmacological studies have shown that cassia seed has good blood lipid-lowering and anti-atherosclerosis effects, and also has good blood pressure, antibacterial, enhancing body immunity and anti-aging effects. The study of chemical composition shows that cassia seed mainly contains anthraquinone compounds, which exist in the form of bound and free anthraquinones. [0003] The preparation method of cassia seed formula granules is to use water as the extraction solvent. The extract is concentrated in low-temperature vacuum, spray-dried, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 谭登平魏梅何健陈向东罗艳萍梁志毅覃日金
Owner GUANGDONG YIFANG PHARMA
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