Preparation method of ferrous gluconate

A technology of ferrous gluconate and gluconic acid, applied in the fields of pharmacy and chemistry, can solve problems such as being difficult to meet the requirements of energy saving, high efficiency and environmental protection of industrial enterprises, and achieve the effects of shortening production time, reducing energy consumption and saving processing costs.

Active Publication Date: 2013-03-27
JIANGXI XINGANJIANG PHARMA
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  • Claims
  • Application Information

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Problems solved by technology

With the advancement of science and technology, the current production process has been difficult to meet the

Method used

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  • Preparation method of ferrous gluconate
  • Preparation method of ferrous gluconate
  • Preparation method of ferrous gluconate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055]according to figure 1 Shown preparation process flow prepares ferrous gluconate:

[0056] 1. Calcium gluconate 650kg, add 25% sulfuric acid based on calcium gluconate weight, react 2 hours time, centrifugal, supernatant passes through 732 sulfonic acid base cation exchange resins and 711 quaternary ammonium base anion exchange resins sequentially, and effluent is gluconic acid solution;

[0057] II. In the described gluconic acid solution that step I obtains, add 100kg iron powder (being equivalent to 15.38% of calcium gluconate weight), react 2.5 hours under 93 ℃, pH=4.3 condition, filter, filtrate decolorizes through active carbon, Concentrate, crystallize, centrifuge, dry, get ferrous gluconate, according to the method for content determination under Chinese Pharmacopoeia 2010 edition two ferrous gluconate items, measure the content of ferrous gluconate, the results are shown in Table 5.

Embodiment 2

[0059] 1. with the step 1 of embodiment 1;

[0060] II. In the gluconic acid solution obtained in step I, add 97.5kg iron powder (equivalent to 15% of the weight of calcium gluconate), react at 90°C and pH=4.1 for 3 hours, filter, and decolorize the filtrate through activated carbon , concentration, crystallization, centrifugation, drying, get ferrous gluconate, according to the method for content determination under the two ferrous gluconate items of Chinese Pharmacopoeia version in 2010, measure the content of ferrous gluconate, the results are shown in Table 5.

Embodiment 3

[0062] 1. with the step 1 of embodiment 1;

[0063] II. In the described gluconic acid solution that step I obtains, add 78kg iron powder (being equivalent to 12% of calcium gluconate weight), react 3 hours under 100 ℃, pH=3.8 condition, filter, filtrate is decolorized through active carbon, Concentrate, crystallize, centrifuge, dry, get ferrous gluconate, according to the method for content determination under Chinese Pharmacopoeia 2010 edition two ferrous gluconate items, measure the content of ferrous gluconate, the results are shown in Table 5.

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Abstract

The invention discloses a preparation method of ferrous gluconate, comprising the steps of: based on calcium gluconate as a raw material, decalcifying by sulfuric acid to obtain gluconic acid; and directly reacting gluconic acid with iron powder to obtain ferrous gluconate, wherein the reaction temperature is 89-100 DEG C, pH is 3.8-4.6, and the adding amount of the iron powder is 12-20% of weight of calcium gluconate. The preparation method is high in yield and product content, and has the advantages of lower energy consumption, shorter preparation cycle and less waste discharge.

Description

technical field [0001] The invention belongs to the fields of pharmacy and chemistry, and in particular relates to a preparation method of ferrous gluconate. Background technique [0002] Ferrous Gluconate (Ferrous Gluconate), molecular formula: C 12 h 22 FeO 14 2H 2 O, molecular weight: 482.17, structural formula as shown in 1; gray-green or light yellow powder or granules; caramel smell, astringent taste. Soluble in hot water, soluble in water, almost insoluble in ethanol. [0003] [0004] The United Nations Food and Agriculture Organization / World Health Organization (FAO / W140) Expert Committee on Food Additives believes that ferrous gluconate is an iron supplement with "usefulness and safety necessity", which is different from the currently clinically used millet sulfate. In comparison, it has significant advantages such as high stability, good taste, low toxicity, small side effects, and easy absorption and utilization by the human body. [0005] The preparati...

Claims

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Application Information

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IPC IPC(8): C07C59/105C07C51/41
Inventor 刘晓鹏陈小华金国强
Owner JIANGXI XINGANJIANG PHARMA
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