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Functional preparation for adjuvant therapy of atopic dermatitis and preparation method

A technology for atopic dermatitis and adjuvant therapy, applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc. problem, to restore the skin barrier function, repair the skin barrier, and achieve the effect of good safety

Inactive Publication Date: 2013-04-03
何黎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Topical glucocorticoids have always been the main means of treating AD, but their side effects have limited long-term and large-scale application. Recently, calcium regulation inhibitors (tacrolimus, pimecrolimus, etc.) have been advocated for external use in the treatment of AD. , but the local burning sensation is the most common side effect and the safety of long-term use is still controversial

Method used

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  • Functional preparation for adjuvant therapy of atopic dermatitis and preparation method
  • Functional preparation for adjuvant therapy of atopic dermatitis and preparation method
  • Functional preparation for adjuvant therapy of atopic dermatitis and preparation method

Examples

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Embodiment 1

[0017] The weight components of the main raw materials of the functional preparation of the present invention are: 0.2 parts of sodium hyaluronate, 5 parts of emulsifying thickener, 5 parts of oil, plus deionized water to 100 parts.

[0018] Preparation method: Add the emulsified thickener (component A) into the water pot and heat it to 75°C; add the oil (component B) into the oil pot and heat it to 75°C; mix the solution of group A and the solution of group B Mix in an emulsifying pot and homogeneously emulsify for 10 minutes; cool the above emulsion to 40°C, add sodium hyaluronate as the main raw material, stir for 20 minutes, discharge, stand still, fill and pack.

Embodiment 2

[0020] The main raw material components of the functional preparation of the present invention are: 0.5 parts of sodium hyaluronate, 8 parts of emulsifying thickener, 8 parts of oil, and deionized water to 100 parts.

[0021] Preparation method: Add the emulsified thickener (component A) into the water pot and heat it to 78°C; add the oil (component B) into the oil pot and heat it to 78°C; mix the solution of group A and the solution of group B Mix in an emulsifying pot and homogeneously emulsify for 12 minutes; cool the above emulsion to 42°C, add sodium hyaluronate as the main raw material, stir for 23 minutes, discharge, stand still, fill and pack.

Embodiment 3

[0023] The functional preparation of the present invention has main raw material components by weight: 1 part of sodium hyaluronate, 10 parts of emulsifying thickener, 10 parts of oil, and deionized water to 100 parts.

[0024] Preparation method: Add the emulsified thickener (component A) into the water pot and heat it to 80°C; add the oil (component B) into the oil pot and heat it to 80°C; mix the solution of group A and the solution of group B Mix in an emulsifying pot and homogeneously emulsify for 15 minutes; cool the above emulsion to 45°C, add sodium hyaluronate as the main raw material, stir for 25 minutes, discharge, stand still, fill and pack.

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Abstract

The invention provides a functional preparation for adjuvant therapy of atopic dermatitis AD and a preparation method thereof. The functional preparation comprising raw material components in parts by weight: 0.2-1 part of sodium hyaluronate, 5-10 parts of emulsifying thickening agent, 5-10 parts of grease and the balance of de-ionized water which enables the total weight to be 100 parts. The functional preparation provided by the invention is the functional preparation containing sodium hyaluronate and is combined with mometasone furoate emulsifiable paste to obviously improve a xerotic eczema symptom, effectively recover a skin barrier function, and reduce the recurrence; the curative effect of the functional preparation combined with mometasone furoate emulsifiable paste is better than that of the single use of the mometasone furoate emulsifiable paste; and the functional preparation can be used for the adjuvant therapy of eczematous dermatitis diseases, has the good curative effect and safety, and reduces the reoccurrence.

Description

technical field [0001] The invention relates to a functional preparation containing sodium hyaluronate that can assist in the treatment of atopic dermatitis (AD), a dermatitis and eczema-like disease, and a preparation method thereof. Background technique [0002] Atopic dermatitis (AD) is a chronic relapsing, pruritic, inflammatory skin disease affecting 10-20% of children and 1-3% of adults worldwide. The pathogenesis of AD is very complex, involving genetic factors, defects in the skin barrier, and immune dysfunction. AD is a chronic skin disease characterized by the dominant expression of Th2-type cytokines, which are related to skin cell immunity and produce excessive IgE. Th cells are divided into three subtypes. PTh cells refer to naive CD4+ T cells, which mainly secrete IL-2. Th1 cells mainly secrete IL-2, IL-12, IFN-r, TNF-a. and mediate cellular immunity. Th2 cells mainly secrete IL-4, IL-5, IL-10, IL-13 and mediate humoral immunity. There are many cytokines in...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61P17/00A61P29/00
Inventor 何黎顾华高绍阳凃颖郭振宇
Owner 何黎
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