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Quality control method of sunset abelmoschus root medicinal material as well as extract and preparation of sunset abelmoschus root

A quality control method, the technology of hollyhock flowers, is applied in the direction of measuring devices, material separation, and analysis of materials, which can solve the problems of being unable to objectively and reasonably control the quality of medicinal materials and their preparations, high detection sensitivity, and good stability

Active Publication Date: 2013-04-03
JIANGSU SUZHONG PHARM GRP CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method has high detection sensitivity and good stability, can objectively, comprehensively and accurately evaluate the quality of the medicinal materials and their extracts and preparations of hollyhock, and can solve the problem that the quality of the medicinal materials and their preparations cannot be objectively and reasonably controlled due to the lack of reference substances. It is of great significance to control the quality and ensure the curative effect

Method used

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  • Quality control method of sunset abelmoschus root medicinal material as well as extract and preparation of sunset abelmoschus root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Preparation of sample solution

[0051] Accurately weigh 0.1 g of hollyhock flower medicinal material, add 20 ml of 70% methanol, ultrasonically extract for 30 min, make up for weighing, filter, take the subsequent filtrate to pass through a 0.45 μm filter membrane, and inject 1 μL into the sample.

[0052] (2) Preparation of reference solution

[0053] Precisely weigh rutin, hyperoside, isoquercitrin, cottoncetin-8-O-glucuronide, myricetin, quercetin-3′-O-glucuronide, and quercetin reference substances Each appropriate amount was placed in a measuring bottle, and 70% methanol was used to prepare reference substance solutions with concentrations of 10 μg / mL, 235 μg / mL, 110 μg / mL, 250 μg / mL, 50 μg / mL, 101 μg / mL, and 16 μg / mL, respectively. Take different volumes of a single reference substance solution, mix and dilute to make a series of mixed reference substance solutions, and store them at 4°C for later use.

[0054] (3) Acquisition of liquid chromatogram

[005...

Embodiment 2

[0072] (1) Preparation of sample solution

[0073] Accurately weigh 0.1 g of hollyhock flower extract, add 50 ml of methanol with a concentration of 90%, ultrasonically extract for 30 min, filter, take the subsequent filtrate to pass through a 0.45 μm filter membrane, and inject 10 μL into the sample.

[0074] (2) Preparation of reference substance solution

[0075] Accurately weigh the appropriate amount of hyperoside, isoquercitrin, cottoncetin-8-O-glucuronide, myricetin, quercetin-3′-O-glucoside, rutin and quercetin reference substances , placed in a volumetric flask, with 90% methanol to prepare reference solutions with concentrations of 87 μg / mL, 401 μg / mL, 264 μg / mL, 462 μg / mL, 450 μg / mL, 751 μg / mL, and 103 μg / mL. Measure different volumes of a single reference substance solution, mix and dilute to make a series of concentration mixed reference substance solutions, and store them at 4°C for later use.

[0076] (3) Acquisition of liquid chromatogram

[0077] Get step (...

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Abstract

The invention discloses a quality control method of a sunset abelmoschus root medicinal material, as well as an extract and a preparation of a sunset abelmoschus root. With the adoption of a liquid chromatographic separation technique, the contents of seven flavone components in the sunset abelmoschus root are calculated with the aid of a one-detection multi-evaluation method by calculating a correction factor. The method is high in detection sensitivity and good in stability, can evaluate the quality of the sunset abelmoschus root medicinal material, the extract thereof and the preparation of the sunset abelmoschus root objectively, comprehensively and accurately, can solve the problem that the quality of the medicinal material and the preparation thereof cannot be controlled objectively and reasonably due to the lack of a control, and has a great significance in controlling the quality and ensuring the curative effect.

Description

technical field [0001] The invention relates to a quality control method of Chinese medicinal materials and preparations thereof, in particular to a quality control method of marshmallow medicinal materials, extracts and preparations thereof. Background technique [0002] Hollyhock flower is the dried flower of hollyhock, a plant of the genus Okra in the Malvaceae family. It tastes sweet, pungent, and cool in nature. [0003] "One test and multiple evaluations" is a new mode of multi-indicator quality evaluation suitable for the characteristics of traditional Chinese medicine. It uses the internal function and proportional relationship between effective chemical components, and only measures one component (the reference substance is available) to achieve multi-factor evaluation. Simultaneous monitoring of three ingredients (the reference substance is not available or difficult to obtain) overcomes the shortage of the reference substance, that is, only a certain representativ...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 唐仁茂段金廒钱大玮郭建明徐柏颐尚尔鑫
Owner JIANGSU SUZHONG PHARM GRP CO LTD
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