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Preparation method of injection capable of improving body immunity

A technology of immunity and injection, applied in the field of medicine, can solve the problems of high technical requirements, high cost, and inability to continue to use, etc., and achieve the effect of convenient use and increased solubility

Inactive Publication Date: 2014-07-02
朱国斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]Leninan has the advantages of small dose, high curative effect, and low toxicity. However, due to its low solubility in water, it must be made into powder injection. Powder injection requires high equipment and technical requirements, making it costly
The multi-component lentinan for intramuscular injection currently available in the market in my country has precipitated after long-term storage, which affects product quality and cannot be used any longer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get 0.5 grams of raw material lentinan for intravenous injection (lentinan content is 99%), add 520 milliliters of 0.5 mol / liter HCl solution under stirring, make it all dissolve, slowly add 0.1 mol / liter of 390 ml of NaOH to make the pH 6.5-6.8. If the pH cannot reach the above range, adjust the pH with a few drops of 0.5 mol / liter HCl solution, filter to remove some insoluble matter, and the filtrate is clear with a concentration of 0.5 mg / ml. Pack 2 ml into each ampoule and sterilize at 120°C for 5 minutes to obtain lentinan injection for intravenous injection. The injection was placed in a refrigerator at 5° C. or at room temperature for six months, no solid was precipitated, and the clarity inspection of the injection was in compliance with the Chinese Pharmacopoeia 90 Edition.

Embodiment 2

[0018] Get 1.05 grams of single lentinan (the content of lentinan is 98%) that can be used for intravenous injection, and slowly drip 850 milliliters of 1.0 mol / liter HCl solution under stirring to dissolve it, and after it is completely dissolved, stir Slowly add 610 ml of NaOH with a concentration of 0.6 mol / liter to make the pH value 6.5-6.8, and the concentration of the filtrate obtained by filtration is 0.5 mg / ml. Each ampoule is filled with 2 ml of the above-mentioned filtrate, and sterilized at 120°C for 2 minutes to obtain Lentinan injection for intravenous injection, the injection was placed at room temperature or in a refrigerator at 5°C for six months, no solid precipitation was found, and the clarity inspection complied with the 90th edition of the Chinese Pharmacopoeia.

Embodiment 3

[0020] Get the multi-component lentinan available for intramuscular injection as raw material (wherein the lentinan content is 21.5%), 900 mg, slowly add 0.7 mol / L HCl140 milliliters under stirring, make it dissolve, after all dissolving, continue Stir, slowly drop 39 ml of 0.3 mol / L NaOH to make the pH value 6.5-6.8, then add water for injection to 300 ml, filter, the concentration of the filtrate is 3 mg / ml, and pack in 2 ml per ampoule, 120 ℃ high-temperature disinfection for 15 minutes to obtain Lentinan Injection for Muscle. The injection was stored at room temperature and in a refrigerator at 5°C for six months, and no solid was precipitated, and the clarity inspection was in compliance with the 90th edition of the Chinese Pharmacopoeia.

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Abstract

The present invention discloses a preparation method that can improve the immunity of the body. The purpose is to solve the problem of the existing muscle injection of multiple groups of mushroom polysaccharides for a long time.Including the following steps: Sololy sugar or multiple sets of mushroom polysaccharides in HCL solution of 0.5-1.0mol / L, add nah-regulating pH value of 0.1-0.6 mol / L to 6.5-6.8, filtrate, filter liquid division divisionThe required amount of installation is to be disinfected at high temperature, which is the product.According to the characteristics of the stable water solution of the mushroom polysaccharides and the smaller solution in the water, find a method that can increase the solubility of mushroom polysaccharides in the water. The long -term placement of the product will not produce precipitation.Essence

Description

technical field [0001] The invention relates to the field of medicine, in particular to polysaccharides, in particular to a method for preparing an injection capable of improving human body immunity. Background technique [0002] Lentinan is a component obtained by extracting, separating and purifying from the fruiting body of Lentinus edodes. Scientists from various countries conducted extensive research on various polysaccharides as early as the early 1970s, and found that polysaccharides can not only treat cancers with severely damaged immune systems, but also treat various immunodeficiency diseases, such as chronic viral hepatitis and certain drug-resistant bacteria. Or chronic diseases caused by viruses, and can also treat autoimmune diseases such as rheumatism. In 1986, Japan first produced and prepared lentinan into powder injections for export abroad. It is mainly used in gastrointestinal cancers such as gastric cancer and rectal cancer. The main route of administra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/715A61K36/06A61P37/04
Inventor 张荣斌
Owner 朱国斌