Porcine transmissible gastroenteritis and epidemic diarrhea combined live vaccine and preparation method thereof

A technology for porcine epidemic diarrhea and epidemic diarrhea, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, digestive system, etc., and can solve the difficulties in ensuring the consistency of cell quality, difficulty in meeting large-scale production, vaccine production, and efficacy And other issues
CN103041385BActive Publication Date: 2014-02-19QILU ANIMAL HEALTH PROD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QILU ANIMAL HEALTH PROD
Publication Date
2014-02-19

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Abstract

The invention relates to a porcine transmissible gastroenteritis and epidemic diarrhea combined live vaccine and a preparation method of the porcine transmissible gastroenteritis and epidemic diarrhea combined live vaccine. The porcine transmissible gastroenteritis and epidemic diarrhea combined live vaccine is prepared by performing virus amplification on a swine testicular cell line (ST cells) or an African green monkey kidney cell line (Vero cells) by using a self-attenuated and preserved transmissible gastroenteritis virus SD / L strain and a self-attenuated and preserved porcine epidemic diarrhea virus LW / L strain, and carrying out the steps of harvesting, uniformly mixing, freeze-drying and the like. The porcine transmissible gastroenteritis and epidemic diarrhea combined live vaccine can effectively prevent two diseases namely swine transmissible gastroenteritis and epidemic diarrhea.
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Description

technical field

[0001] The invention relates to a porcine transmissible gastroenteritis and epidemic diarrhea dual live vaccine, which belongs to the field of veterinary biological products. Background technique

[0002] Porcine transmissible gastroenteritis is a highly contagious, fatal infectious disease of pigs caused by Transmissible gastroenteritis virus (TGEV), which causes vomiting, severe diarrhea and dehydration in piglets under 2 weeks of age as the main feature. Among them, the mortality rate of piglets within 2 weeks of age can reach 100%, and the mortality rate of pigs over 5 weeks of age is relatively low. Larger or adult pigs hardly die, but it can cause fat loss, reduce feed remuneration, increase medicine and manpower expenses, etc. , causing serious losses. The disease has been widely prevalent in the United States since 1933. The pathogen of the disease was determined by Doyle et al. in 1946. After that, many countries and regions in the world (Japan, Br...

Claims

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