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Quick screening method of indometacin added illegally in Chinese patent medicine and health-care products

A technology of indomethacin and illegal addition, which is applied in the preparation of test samples, material analysis by observing the impact on chemical indicators, and analysis by making materials undergo chemical reactions, which can solve the problems of low detection sensitivity and traditional Chinese medicine. The background color of the extract is dark, it is difficult to judge the solution to turn red, etc., to achieve the effects of reducing interference, improving detection sensitivity, and high application value

Active Publication Date: 2014-12-31
东莞市食品药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above method, a large amount of precipitates are often generated in the reaction, and the background color of the traditional Chinese medicine extract is dark, it is difficult to judge that the solution turns red, and the detection sensitivity is low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A rapid screening method for illegally adding indomethacin in Chinese patent medicines and health products, which sequentially includes the following steps:

[0031] Step A, sampling: take half a capsule of Fengtongning produced by Jisheng, Guangxi;

[0032] Step B. Preparation of sample solution: Take the sample obtained in step A and put it into a 5mL bottle filled with 0.1% sodium hydroxide solution by mass percentage, cover it tightly, shake it vigorously for 20 seconds, and pour 1mL of the supernatant after standing still. Put it into a bottle containing 3 mL of hydrochloric acid solution with a concentration of 2 mol / L, mix it evenly, and filter it with an organic filter membrane and a syringe filter with a pore size of 0.45 μm, and take 2 mL of the filtrate;

[0033] Step C, inspection: Add 1 drop of ferric chloride solution with a mass percentage concentration of 10% to the filtrate obtained in step B, mix evenly, and after 5 minutes, the solution turns red unde...

Embodiment 2

[0035] A rapid screening method for illegally adding indomethacin in Chinese patent medicines and health products, which sequentially includes the following steps:

[0036] Step A, sampling: take half a Gastrodia elata capsule produced by Xiuzheng Pharmaceutical;

[0037] Step B. Preparation of sample solution: Take the sample obtained in step A and put it into a 5mL bottle filled with 0.2% sodium hydroxide solution by mass percentage, cover it tightly, shake it vigorously for 30 seconds, and pour 1mL of the supernatant after standing still. Put it into a bottle containing 3 mL of hydrochloric acid solution with a concentration of 2 mol / L, mix it evenly, and filter it with an organic filter membrane and a syringe filter with a pore size of 0.45 μm, and take 2 mL of the filtrate;

[0038] Step C, inspection: add 1 drop of ferric chloride solution with a mass percentage concentration of 5% to the filtrate obtained in step B, mix well, and the solution does not turn red to purple...

Embodiment 3

[0041] A rapid screening method for illegally adding indomethacin in Chinese patent medicines and health products, which sequentially includes the following steps:

[0042] Step A, sampling: take half a Gujinwan capsule produced by Harbin Pharmaceutical No. 6 Factory;

[0043] Step B. Preparation of sample solution: Take the sample obtained in step A and put it into a 5mL bottle filled with 0.4% sodium hydroxide solution by mass percentage, cover tightly, shake vigorously for 20-40 seconds, and take 1mL supernatant after standing still Pour the solution into a bottle containing 3 mL of 2 mol / L hydrochloric acid solution, mix well, and then filter with an organic filter membrane and a syringe filter with a pore size of 0.45 μm, and take 2 mL of the filtrate;

[0044] Step C, inspection: Add 1 drop of ferric chloride solution with a mass percentage concentration of 3% to the filtrate obtained in step B, mix well, mix well, and after 5 minutes, the solution does not change to Re...

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Abstract

The invention discloses a quick screening method of indometacin added illegally in Chinese patent medicine and health-care products. The method comprises the following steps: A, sampling; B, placing a sample in a 5 mL bottle filled with 0.1 to 0.4% of sodium hydroxide solution, fastening down a bottle cap, vibrating and shaking for 20 to 40 seconds powerfully, taking 1 mL supernate and pouring in a bottle filled with a 3 mL hydrochloric acid solution with the concentration of 2 mol / L after standing, and filtering by a syringe-driven filter after uniformly mixing, and taking 2 mL filtrate; and C, adding one drop of 3 to 10% of ferric trichloride solution in the filtrate, uniformly mixing, and after 5 minutes, if the color of the solution becomes red to purple red, the condition that indometacin exists in the sample can be judged. The method reduces the interference of complex components in Chinese patent medicine, so that the detection sensitivity is improved, an organic solvent is not required to be used, no extra equipment is required, nontoxicity and environmental protection are achieved, a commercialized quick screening kit can be manufactured, and the quick screening method is not only used for field screening of drug regulatory departments, but also widely applicable to other any places.

Description

technical field [0001] The invention belongs to the technical field of drug detection, and in particular relates to a rapid screening method for illegally adding indomethacin in Chinese patent medicines and health care products. Background technique [0002] Rheumatic patients are a huge group. Because rheumatism is easy to relapse and difficult to cure, many patients choose Chinese patent medicines and health products with lower side effects for treatment. However, due to the slow onset of Chinese patent medicines and health care products, some lawbreakers took advantage of people's eagerness to see the effect, illegally added chemical drugs other than prescriptions, advocated "quick-acting" and "high-efficiency", and exaggerated the efficacy of publicity. Illegal addition of indomethacin to anti-rheumatic health products is relatively common. The health products involved include Chinese patent medicines, health food, etc., and the dosage forms involved are capsules, table...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N1/28
Inventor 廖瑜柯咏伽林慧菁
Owner 东莞市食品药品检验所