Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Effective part of Houttuynia cordata as well as extracting method and application thereof

A technology of effective parts and extraction methods, which is applied in the field of extracting effective parts of the plant Houttuynia cordata to prepare anti-tumor drugs, and achieves the effect of simple extraction method and strong anti-tumor activity

Active Publication Date: 2013-04-24
河南省医药科学研究院
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports that the volatile oil, ethyl acetate part or ethanol part of Houttuynia cordata have anti-tumor effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Effective part of Houttuynia cordata as well as extracting method and application thereof
  • Effective part of Houttuynia cordata as well as extracting method and application thereof
  • Effective part of Houttuynia cordata as well as extracting method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] An effective part of Houttuynia cordata, which is selected from one or more mixtures of Houttuynia cordata volatile oil, Houttuynia cordata ethyl acetate fraction and Houttuynia cordata ethanol fraction.

[0017] The extraction method of the effective parts of Houttuynia cordata comprises the following steps: take 500g of crushed whole herb of Houttuynia cordata and put it in a flask (several zeolites can be put in the flask), add 5000ml of water, shake and mix, soak for about 12 hours , and then steam distill Houttuynia cordata and soaking solution (keep boiling for 6 hours), and collect the distillate. After the distillate is allowed to stand for cooling and stratification, take the upper light yellow oil layer (about 0.5ml) to obtain the volatile oil of Houttuynia cordata; dry the residue of Houttuynia cordata extracted with water, then use 7500ml of petroleum ether, 7500ml of ethyl acetate and 7500ml 95% ethanol reflux extraction for 3 hours (that is, after the refl...

Embodiment 2

[0019] An effective part of Houttuynia cordata, which is selected from one or more mixtures of Houttuynia cordata volatile oil, Houttuynia cordata ethyl acetate fraction and Houttuynia cordata ethanol fraction.

[0020] The extraction method of the effective part of Houttuynia cordata comprises the following steps: take 500g of the whole herb of Houttuynia cordata pulverized and put it in a flask (several zeolites can be put in the flask), add 6000ml of water, shake and mix, soak for about 15 hours , and then steam distill Houttuynia cordata and soaking solution (keep boiling for 8 hours), and collect the distillate. After the distillate is allowed to stand for cooling and stratification, take the upper light yellow oil layer (about 0.6ml) to obtain the volatile oil of Houttuynia cordata; dry the residue of Houttuynia cordata extracted with water, then use 10000ml petroleum ether, 10000ml ethyl acetate and 10000ml 95% ethanol was refluxed for extraction for 4 hours, and the ob...

Embodiment 3

[0022] An effective part of Houttuynia cordata, which is selected from one or more mixtures of Houttuynia cordata volatile oil, Houttuynia cordata ethyl acetate fraction and Houttuynia cordata ethanol fraction.

[0023] The extraction method of the effective parts of Houttuynia cordata comprises the following steps: take 500g of crushed whole Houttuynia cordata herb and put it in a flask (several zeolites can be put in the flask), add 4000ml of water, shake and mix, soak for about 10h , and then steam distill Houttuynia cordata and soaking solution (keep boiling for 10 hours), and collect the distillate. After the distillate is allowed to stand for cooling and stratification, take the upper light yellow oil layer (about 0.4ml) to obtain the volatile oil of Houttuynia cordata; dry the residue of Houttuynia cordata extracted with water, then use 9000ml of petroleum ether, 9000ml of ethyl acetate and 9000ml of 95% ethanol was refluxed for extraction for 1 hour, and the obtained e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an effective part of Houttuynia cordata. The effective part of Houttuynia cordata is selected from one or a mixture of more than two of Houttuynia cordata volatile oil, Houttuynia cordata ethyl acetate extract and Houttuynia cordata ethyl ethanol. The extracting method of the effective part of Houttuynia cordata comprises the following steps of: carrying out steam distillation for Houttuynia cordata soaked by water to collect distillate; standing, cooling and layering the distillate and taking the upper oil layer to obtain the Houttuynia cordata volatile oil; airing or drying Houttuynia cordata extracted by water, and sequentially carrying out reflux extraction by petroleum ether, ethyl acetate and ethanol; and volatilizing a solvent of the extracting liquor to respectively obtain the Houttuynia cordata ethyl acetate extract and Houttuynia cordata ethyl ethanol. The effective part of Houttuynia cordata has a better anti-tumor effect for human hepatoma carcinoma cells HepG2, human breast cancer cells MCF-7, human lung cancer cells A549 and human lymphoma cells Raji, and can be used to prepare anti-tumor medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an extract of effective parts of the plant Houttuynia cordata, an extraction method and its application in the preparation of antitumor drugs. Background technique [0002] Houttuynia cordata Thunb (Houttuynia cordata Thunb) is a plant of the genus Houttuynia cordata, formerly known as "Houttuynia cordata Thunb". Distributed in the south of the Yangtze River Basin, mainly produced in Zhejiang, Jiangsu, Anhui, Fujian, Henan and other provinces. The whole herb with roots is used medicinally, pungent in nature, slightly cold in taste, and enters the lung meridian. It has the functions of clearing heat and detoxifying, eliminating carbuncle and discharging pus, diuresis and treating stranguria. "Broad Spectrum Antibiotics in Traditional Chinese Medicine". "Compendium of Materia Medica" records: "Its leaves have a fishy smell, so it is commonly kno...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/78A61P35/00
Inventor 张壮丽郑立运赵志鸿张小俊王桂芳张长征陈慧平邹敏张艳王宁马方王东阳王庆端江金花王陆巡赵宁
Owner 河南省医药科学研究院
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com