Magnetic responsive micro valve based on micro-fluidic chip and production method thereof

Abstract

The invention relates to a magnetic responsive micro valve based on a micro-fluidic chip and a production method thereof. Microstructures and micro-channels are arranged on the surface of the micro-fluidic chip, a hydrophilic / dehydrophilic gate controlled switch is arranged on a main micro-channel, the surfaces of the micro-channels are modified through magnetic responsive molecules, reversible changes of surface appearance and chemical construction of the micro-channels cause changes of surface invasion under stimulation of an outer magnetic field, movement of micro-fluid on the surfaces of the micro-channels is controlled, and therefore the intelligent micro valve achieves control on micro-fluid flowing. The magnetic responsive micro valve is mainly applied to the related fields such as electrophoretic separation, chromatographic separation and immunoassay, achieves intelligent driving and control on micro-fluid, greatly reduces micro-fluid driving and control cost, has the advantages of being portable, economical, fast and efficient, and is a novel analysis technique for micro-fluid driving and control.

Description

technical field [0001] The invention relates to a magnetically responsive microvalve based on a microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the main microchannel is provided with a hydrophilic / hydrophobic gating switch. Molecules modify the surface of the microchannel. Under the stimulation of an external electric field, the reversible change of the surface morphology and chemical configuration of the microchannel leads to the change of surface wettability, which controls the movement of the liquid fluid on the surface of the microchannel, thereby realizing the microchannel The intelligent microvalve for fluid flow control is mainly used in electrophoretic separation, chromatographic separation, immunoassay and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, c...

AI Technical Summary

Problems solved by technology

In terms of microvalve research, it is divided into active and passive valves according to whether there is a power drive mechanism. This type of microvalve can realize the opening / closing of the valve, has good braking performance and high airtightness, but the disadvantage is that the structure is complex, the volume is large, and it is difficult to realize the integration on the chip.

Passive valves do not require external dynamic braking, and rely on the pressure difference on both sides of the valve to realize the switch. Its volume is small, but it cannot actively open / close or switch the valve

[0004] However, it is difficult for conventional technologies to achieve intelligent driving and control of microfluidics in microchannels. Therefore, by using an external magnetic field to control the change of surface wettability to drive and control microfluidics in microfluidic chips, the development of a Convenient, fast, efficient, and low-cost microfluidic drive and control technology should be one of the research directions for microvalve on microfluidic chips, and there has been no substantial breakthrough yet

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