Alcohol precipitation device with combination of high pressure atomization and countercurrent and method
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A high-pressure atomization, countercurrent technology, applied in chemical instruments and methods, feeding/discharging devices of sedimentation tanks, separation methods, etc., can solve the problems of discontinuity in the whole process, low product recovery rate, unstable quality, etc. Achieve the effect of sufficient alcohol precipitation, high product recovery rate, uniform and stable quality
Active Publication Date: 2013-05-01
XIAN HONSON BIOTECH
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[0003] In order to overcome the shortcomings of the current alcohol precipitation process, such as unstable quality between batches, discontinuous whole process, low production efficiency, and low product recovery rate, the present invention provides an alcohol precipitation device and method with high-pressure atomization combined with countercurrent, which has the advantages and is easy to The characteristics of operation, continuous production and high recovery rate
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Embodiment 1
[0021] The present embodiment is illustrated by taking the salvia miltiorrhiza extract as an example, including the following steps:
[0022] Step 1, adding ethanol in advance: add 3 / 4 tank volume of ethanol in alcohol precipitation tank 3;
[0023] Step 2. Stirring: Add 600L of salvia miltiorrhiza water extract with a specific gravity of 1.18 into the mixing tank 1, turn on the stirring device 7 on the mixing tank 1, stir for 30 minutes, and the stirring rate is 80r / min; open the valve 11 and feed the liquid The pump 8 sends the feed liquid into the transfer tank 2;
[0024] Step 3. High-pressure atomization combined with countercurrent alcohol precipitation: Turn on the plunger pump 9, adjust the plunger pump pressure to 2.5Mpa, and the flow rate to 300L / h, and spray the salvia miltiorrhiza extract into a mist through the high-pressure pipeline and the first nozzle 18 in sequence Drop into the alcohol precipitation tank 3, the first nozzle 18 is embedded in the ethanol liqu...
Embodiment 2
[0028] It is basically the same as Example 1, except that the specific gravity of salvia miltiorrhiza extract in step 2 is 1.20, and the stirring time is 25min; Add 85% ethanol countercurrently at the flow rate.
[0029] After the clear liquid was concentrated under reduced pressure, 415L of alcohol-immersed paste was obtained, 152kg of precipitate was obtained, and the recovery rate of total phenolic acids of Salvia miltiorrhiza was 91%.
Embodiment 3
[0031] It is basically the same as Example 1, except that the specific gravity of the salvia miltiorrhiza extract in step 2 is 1.15, and it is stirred for 20 minutes; 85% ethanol.
[0032] After the clear liquid was concentrated under reduced pressure, 430L of alcohol-immersed cream was obtained, 142kg of precipitate was obtained, and the recovery rate of total phenolic acids of Salvia miltiorrhiza was 92.5%.
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Abstract
The invention provides an alcohol precipitation device with the combination of high pressure atomization and countercurrent and a method. A stirring tank is communicated with a transit tank connected with an alcohol precipitation tank, and the alcohol precipitation tank is communicated with a standing tank; and the lower part of the alcohol precipitation tank is connected with a solvent storage tank, and a centrifugal machine is connected with the alcohol precipitation tank and communicated with the standing tank. The method comprises the steps that after a salviae miltiorrhizae aqueous extract is stirred, a feed liquid is sprayed into an ethanol solvent which is prepared in advance by a plunger pump through high pressure atomization, simultaneously ethanol is sprayed in a countercurrent manner, so that the feed liquid is fully contacted with a new solvent, and an excellent separation effect can be realized; and an supernatant liquor overflows to enter the standing tank for standing, alcohol precipitation sediments are centrifuged by the centrifugal machine, and then all liquors enter the standing tank to stand for 24 hours. The alcohol precipitation device combing high pressure atomization with countercurrent and the method are suitable for the alcohol precipitation of products such as Chinese medical extracts and the like and have the advantages of stable product quality, high effective component recovery rate, possibility in automation and continuous production, low equipment investment and operation cost, and the like.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine separation and purification technology and equipment, and in particular relates to a high-pressure atomization combined with countercurrent alcohol precipitation device and method. Background technique [0002] In the late 1950s, there were records of water extraction and alcohol precipitation in the extraction process of traditional Chinese medicine. Up to now, a considerable proportion of traditional Chinese medicine preparations, especially traditional Chinese medicine injections, have adopted the process of water extraction and alcohol precipitation, which uses the difference in solubility of water and ethanol to the active and ineffective components to separate and refine them, improve the clarity of the preparation, and improve the quality of the medicine. liquid quality. The specific operation is: the Chinese medicinal materials are extracted with water, concentrated to obtain t...
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