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Intestine and stomach health tablet containing Daphniphyllum calycinum Benth. and polygonum hydropiper L and extraction process of intestine and stomach health tablet

An extraction process and gastrointestinal technology, applied in the field of Fenglian Changweikang tablet and its alcohol precipitation process, can solve the problems of many impurities in the extract and loss of effective components, and achieve short extraction time, broad application prospects and markets, and removal of impurities. Effect

Pending Publication Date: 2021-06-18
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on this, the purpose of the present invention is to overcome the shortcoming that exists in the prior art, provide a kind of extraction technology of Feng Liao Chang Wei Kang tablet, to solve the problem that there are many impurities in the extract liquid in the extraction process of Feng Liao Chang Wei Kang tablet in the prior art, active ingredient For the problem of more losses, the extraction process of Fenglian Changweikang Tablets in the present invention is simple and stable, suitable for industrial production, and the Fenglian Changweikang Tablets prepared by this preparation method have good therapeutic effect, good quality and high safety

Method used

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  • Intestine and stomach health tablet containing Daphniphyllum calycinum Benth. and polygonum hydropiper L and extraction process of intestine and stomach health tablet
  • Intestine and stomach health tablet containing Daphniphyllum calycinum Benth. and polygonum hydropiper L and extraction process of intestine and stomach health tablet
  • Intestine and stomach health tablet containing Daphniphyllum calycinum Benth. and polygonum hydropiper L and extraction process of intestine and stomach health tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 2 as shown, figure 2 It is a flow chart of the extraction process of Fengliao Changweikang Tablets of the present invention, and the extraction process comprises the following steps:

[0026] (1) Soaking: Put the selected maple and Polygonum japonica into the extraction tank successively according to the mass ratio of 2:1, add 8 times the amount (w / w) of water, and soak for 45 minutes;

[0027] (2) Decoction: including primary decoction and secondary decoction

[0028] One decoction: The soaked medicinal materials are decocted once, and when the temperature rises to 100°C, the steam valve is quickly closed, and then the steam valve of the jacket of the extraction tank is opened, and the medicinal liquid in the extraction tank is heated through the jacket to make the inside of the extraction tank The medicinal liquid is in a slightly boiling state, and decocted for 2 hours to obtain a decoction. Open the liquid outlet valve of the extraction tank to e...

Embodiment 2

[0038] The preparation process of Fenglian Changweikang Pianqing Ointment in this example is exactly the same as that in Example 1, and will not be repeated here. The difference between the alcohol precipitation process of Fengliao Changweikang Tablets and Example 1 of this embodiment is as follows:

[0039] Step S1: Alcohol precipitation once, transport the concentrated clear ointment with a relative density of 1.10 to the alcohol precipitation tank through the pipeline, confirm the volume of the clear ointment through the sight glass and the scale mark, add 35% ethanol, and mix it with the clear ointment The volume ratio is 1.5:1, stir while adding, stir for 10-30 minutes;

[0040] Step S2: second alcohol precipitation, continue to add 95% ethanol, and stir while adding, when the alcohol content of the clear paste is 50%, continue to stir for 10 to 30 minutes;

[0041] Step S3: ultrasonic treatment, the stirred paste was ultrasonically treated for 45 minutes, then cooled an...

Embodiment 3

[0043] The preparation process of Fenglian Changweikang Pianqing Ointment in this example is exactly the same as that in Example 1, and will not be repeated here. The difference between the alcohol precipitation process of Fengliao Changweikang Tablets and Example 1 of this embodiment is as follows:

[0044] Step S1: Alcohol precipitation once, transport the concentrated clear ointment with a relative density of 1.1 to the alcohol precipitation tank through the pipeline, confirm the volume of the clear ointment through the sight glass and the scale mark, add 40% ethanol, and mix it with the clear ointment The volume ratio is 1:1, stir while adding, stir for 10-30 minutes;

[0045] Step S2: second alcohol precipitation, continue to add 95% ethanol, and stir while adding, when the alcohol content of the clear paste is 55%, continue to stir for 10 to 30 minutes;

[0046] Step S3: ultrasonic treatment, the stirred paste was ultrasonically treated for 45 minutes, then cooled and l...

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Abstract

The invention relates to an intestine and stomach health tablet containing Daphniphyllum calycinum Benth. and polygonum hydropiper L and an extraction process of the intestine and stomach health tablet. The extraction process comprises the following steps: (1) carrying out soaking; (2) carrying out decocting; (3) carrying out concentrating to prepare paste; (4) carrying out alcohol precipitation; and (5) drying the paste. The alcohol precipitation process comprises the following steps: S1, performing primary alcohol precipitation; S2, performing secondary alcohol precipitation; S3, performing ultrasonic treatment; and S4, performing concentrating and recycling ethanol. According to the extraction process, the alcohol precipitation process is added, so that impurities can be rapidly removed, loss of active ingredients is reduced, and dosage is reduced. Moreover, in the added alcohol precipitation process, cooling in advance is not required, so that the overall alcohol precipitation time is shortened, and the probability that substances such as starch and proteins are directly in contact with a high-concentration ethanol solution to be rapidly precipitated to form a wrapping solution is reduced. Furthermore, the ultrasonic treatment process is added in the precipitation process, and the formed wrapping solution can be destroyed by utilizing the secondary effect of ultrasonic waves such as mechanical vibration, diffusion and crushing, so that diffusion and release of the to-be-extracted components are accelerated, the to-be-extracted components are fully mixed with a solvent, the overall alcohol precipitation time is greatly shortened, and the alcohol precipitation is more sufficient.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to Feng Liao Chang Wei Kang tablets and an alcohol precipitation process thereof. Background technique [0002] Feng Liao Chang Wei Kang is a classic traditional Chinese medicine compound for the prevention and treatment of gastrointestinal diseases. It is composed of two traditional Chinese medicines, Niu Er Feng and Lai Polygonum, in a ratio of 2:1. Daphniphyllum calycinum Benth., also known as Daphniphyllum calycinum Benth., is a plant of the genus Daphniphyllum calycinum in the family Daphniphyllaceae. It has extremely high medicinal value, and its fruit and its branches and leaves can be used as medicine. This medicine has the effects of promoting blood circulation and dispelling blood stasis, expelling wind and relieving pain, stopping dysentery and clearing away heat, and is mainly used for diseases such as dysentery, rheumatism ostalgia, co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/20A61P1/04A61P1/00A61K36/185
CPCA61K9/2059A61K36/185A61K36/704A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61P1/00A61P1/04A61K2300/00
Inventor 许松青许丹青许荣煌
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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