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Ganmaoling granules and ethanol precipitation technology thereof

An alcohol precipitation process and Ganmaoling technology are applied in the fields of plant raw materials, respiratory diseases, organic active ingredients, etc., which can solve the problems of insufficient alcohol precipitation, inability to mix the medicinal liquid evenly, and long alcohol precipitation time, so as to shorten the alcohol precipitation. time, to meet large-scale industrial production, the effect of short extraction time

Inactive Publication Date: 2019-12-13
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on this, the purpose of the present invention is to overcome the shortcomings in the prior art, and provide an alcohol precipitation process for Ganmaoling granules, so as to solve the problem of the inability to quickly mix the medicinal liquid and alcohol precipitation in the alcohol precipitation process of Maoling granules in the prior art. Insufficient alcohol precipitation time is too long, the alcohol precipitation process of Ganmao granules in the present invention is simple and stable, suitable for industrial production, and Ganmaoling granules prepared by this preparation method have good therapeutic effect, good quality and high safety

Method used

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  • Ganmaoling granules and ethanol precipitation technology thereof
  • Ganmaoling granules and ethanol precipitation technology thereof
  • Ganmaoling granules and ethanol precipitation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation technology of Ganmaoling Granule Clear Cream of the present embodiment comprises the following steps:

[0025] Step A: One decoction

[0026] Put the selected Sanchaku, Marigold Silver Plate, Wild Chrysanthemum, and Gangmei into the extraction tank in sequence according to the formula amount, add 8 times the amount (w / w) of water, soak for 45 minutes, and then decoct once. When the temperature reaches 100°C, quickly close the steam valve, then open the steam valve of the jacket of the extraction tank, and heat the medicinal liquid in the extraction tank through the jacket, so that the medicinal liquid in the extraction tank is in a slightly boiling state, and decoct for 2 hours to obtain a decoction. Open the liquid outlet valve of the extraction tank to extract the medicinal liquid, make the primary decoction enter the liquid storage tank, and then close the liquid outlet valve of the extraction tank.

[0027] Step B: Second decoction

[0028] Contin...

Embodiment 2

[0037] The preparation process of Ganmaoling granule clear ointment in this example is exactly the same as that in Example 1, and will not be repeated here. The difference between the present embodiment Ganmaoling granule alcohol precipitation process and embodiment 1 is as follows:

[0038] Step S1: Alcohol precipitation once, transport the concentrated clear ointment with a relative density of 1.1 to the alcohol precipitation tank through the pipeline, confirm the volume of the clear ointment through the sight glass and the scale mark, add 50% ethanol, and it is mixed with the clear ointment The volume ratio is 1.5:1, stir while adding, and stir for 10 to 30 minutes;

[0039] Step S2: second alcohol precipitation, continue to add 95% ethanol, and stir while adding, when the alcohol content of the clear paste is 65%, continue to stir for 10 to 30 minutes;

[0040] Step S3: ultrasonic treatment, the stirred paste was ultrasonically treated for 45 minutes, then cooled and left s...

Embodiment 3

[0042] The preparation process of Ganmaoling granule clear ointment in this example is exactly the same as that in Example 1, and will not be repeated here. The difference between the present embodiment Ganmaoling granule alcohol precipitation process and embodiment 1 is as follows:

[0043] Step S1: Alcohol precipitation once, transport the concentrated clear ointment with a relative density of 1.1 to the alcohol precipitation tank through the pipeline, confirm the volume of the clear ointment through the sight glass and the scale mark, add 60% ethanol, and mix it with the clear ointment The volume ratio is 1:1, stir while adding, and stir for 10 to 30 minutes;

[0044] Step S2: secondary alcohol precipitation, continue to add 95% ethanol, and stir while adding, when the alcohol content of the clear paste is 85%, continue to stir for 10 to 30 minutes;

[0045] Step S3: ultrasonic treatment, the stirred paste was ultrasonically treated for 45 minutes, then cooled and left sta...

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Abstract

The invention relates to Ganmaoling granules and an ethanol precipitation technology thereof. The ethanol precipitation technology comprises the following steps of S1, performing ethanol precipitationfor the first time; S2, performing ethanol precipitation for the second time; S3, performing ultrasonic treatment; and S4, performing concentration, and recovering ethanol. According to the ethanol precipitation technology, cooling for reducing the temperature is not needed in advance, so that the whole ethanol precipitation time is shortened, and the possibility that substances of starch, protein and the like are in direct contact with a high-concentration ethanol solution to rapidly coagulate to form wrapping liquid is reduced. Further, in the coagulation process, an ultrasonic treatment working procedure is added, the formed wrapping liquid can be destroyed through secondary effects of ultrasonic such as mechanical vibration, diffusion, smashing and the like, diffusion and release of components to be extracted are accelerated, the components to be extracted are sufficiently mixed with a solvent, the whole ethanol precipitation time is greatly shortened, and ethanol precipitation ismore sufficient. The ethanol precipitation process flow of the Ganmaoling granules disclosed by the invention is succinct, simple and stable, ethanol precipitation is sufficient, the extraction timeis short, the production rate is high, requirements for large-scale industrial production can be met, and the Ganmaoling granules have wider application prospects and market.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Ganmaoling granule and an alcohol precipitation process thereof. Background technique [0002] Ganmaoling Granules are recorded in the eighth volume of Chinese medicine prescription preparations in the drug standard of the People's Republic of China. Peppermint oil is composed of eight raw materials, has antipyretic and analgesic effects, and is used for headache, fever, nasal congestion, sore throat, etc. caused by colds. In the prescription, the four traditional Chinese medicines all have the effect of clearing away heat and detoxifying, and are widely used in the treatment and prevention of colds and other febrile diseases. etc., have obvious antibacterial and antiviral effects; calendula silver plate relieves heat, detoxifies, and dissipates blood stasis, and is mainly used for influenza, Japanese encephalitis, sore throat, etc., and has o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/16A61P11/00A61P29/00A61K31/167A61K31/4402A61K31/522
CPCA61K9/1682A61K31/167A61K31/4402A61K31/522A61K36/185A61K36/28A61K36/287A61K36/534A61K36/754A61K2236/331A61K2236/39A61K2236/53A61P11/00A61P29/00A61K2300/00
Inventor 林忠泽张清民许荣煌
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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