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A high-pressure atomization combined with countercurrent alcohol precipitation device and method

A high-pressure atomization, countercurrent technology, applied in chemical instruments and methods, feeding/discharging devices of sedimentation tanks, separation methods, etc., can solve the problems of discontinuity in the whole process, low product recovery rate, unstable quality, etc. Achieve the effect of sufficient alcohol precipitation, high product recovery rate, uniform and stable quality

Active Publication Date: 2014-10-22
XIAN HONSON BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the shortcomings of the current alcohol precipitation process, such as unstable quality between batches, discontinuous whole process, low production efficiency, and low product recovery rate, the present invention provides an alcohol precipitation device and method with high-pressure atomization combined with countercurrent, which has the advantages and is easy to The characteristics of operation, continuous production and high recovery rate

Method used

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  • A high-pressure atomization combined with countercurrent alcohol precipitation device and method

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Experimental program
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Effect test

Embodiment 1

[0021] The present embodiment is illustrated by taking the water-extracted extract of Salvia miltiorrhiza as an example, and includes the following steps:

[0022] Step 1, add ethanol in advance: add the ethanol of 3 / 4 tank volume in alcohol precipitation tank 3;

[0023] Step 2, stirring: 600L of Salvia miltiorrhiza water extract with a specific gravity of 1.18 is added to the stirring tank 1, and the stirring device 7 on the stirring tank 1 is opened, and after stirring for 30 minutes, the stirring rate is 80r / min; Open the valve 11 and the material and liquid transportation The pump 8 sends the material liquid into the transfer tank 2;

[0024] Step 3, high pressure atomization combined with countercurrent alcohol precipitation: turn on the plunger pump 9, adjust the plunger pump pressure to 2.5Mpa, the flow rate 300L / h, pass through the high pressure pipeline and the first nozzle 18 in turn, spray the Salvia miltiorrhiza extract into a misty liquid Drop into the alcohol p...

Embodiment 2

[0028] Basically the same as Example 1, the difference is: in step 2, the specific gravity of Salvia miltiorrhiza extract is 1.20, and the stirring time is 25min, and in step 3, the pressure of the plunger pump is 3.5Mpa, and the flow rate is 350L / h. Add 85% ethanol in countercurrent to the flow rate.

[0029] After the clear liquid was concentrated under reduced pressure, 415L of alcohol immersion cream was obtained, 152kg was precipitated, and the total phenolic acid recovery rate of Salvia miltiorrhiza was 91%.

Embodiment 3

[0031] Basically the same as Example 1, the difference is: in step 2, the specific gravity of Salvia miltiorrhiza extract is 1.15, stirring for 20min, in step 3, the pressure of the plunger pump is 4Mpa, and the flow rate is 400L / h, and after 8 minutes of spraying, add in countercurrent with 2400L / h 85% ethanol.

[0032] After the clear liquid was concentrated under reduced pressure, 430L of alcohol immersion ointment was obtained, with a precipitation of 142kg, and the recovery rate of total phenolic acids of Salvia miltiorrhiza was 92.5%.

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Abstract

The invention provides an alcohol precipitation device with the combination of high pressure atomization and countercurrent and a method. A stirring tank is communicated with a transit tank connected with an alcohol precipitation tank, and the alcohol precipitation tank is communicated with a standing tank; and the lower part of the alcohol precipitation tank is connected with a solvent storage tank, and a centrifugal machine is connected with the alcohol precipitation tank and communicated with the standing tank. The method comprises the steps that after a salviae miltiorrhizae aqueous extract is stirred, a feed liquid is sprayed into an ethanol solvent which is prepared in advance by a plunger pump through high pressure atomization, simultaneously ethanol is sprayed in a countercurrent manner, so that the feed liquid is fully contacted with a new solvent, and an excellent separation effect can be realized; and an supernatant liquor overflows to enter the standing tank for standing, alcohol precipitation sediments are centrifuged by the centrifugal machine, and then all liquors enter the standing tank to stand for 24 hours. The alcohol precipitation device combing high pressure atomization with countercurrent and the method are suitable for the alcohol precipitation of products such as Chinese medical extracts and the like and have the advantages of stable product quality, high effective component recovery rate, possibility in automation and continuous production, low equipment investment and operation cost, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine separation and purification technology and equipment, and particularly relates to a high-pressure atomization combined with countercurrent alcohol precipitation device and method. Background technique [0002] In the late 1950s, there were records of water extraction and alcohol precipitation in the extraction process of traditional Chinese medicine. Up to now, a considerable proportion of traditional Chinese medicine preparations, especially traditional Chinese medicine injections, have adopted the water extraction and alcohol precipitation process. liquid quality. The specific operation is: the Chinese medicinal materials are extracted with water, concentrated to obtain the extract, and then precipitated with a certain volume and degree of ethanol to remove impurities. It is soluble in water and ethanol, and the impurities such as mucus, gelatinized starch and pectin can be effectiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D11/00A61K36/537A61K36/00B01D21/02B01D21/24B01D21/30B01D21/34
Inventor 沈志刚李翠芹徐维玲
Owner XIAN HONSON BIOTECH
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