Magnesium or magnesium alloy-porous hydroxyapatite composite and preparation method thereof

A technology of porous hydroxyapatite and hydroxyapatite, which is applied in heat exchange equipment, stators, transmissions, etc., can solve the problems of inability to guarantee the dual connectivity of hydroxyapatite, the existence of porous morphology, and limited osteoinductivity , to achieve the effect of increasing strength, avoiding fragmentation, and convenient operation

Inactive Publication Date: 2013-05-01
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Although biomedical and clinical studies have shown that porous hydroxyapatite has good osteoinductivity, and its pore size is best at hundreds of microns, but the previous magnesium alloy-hydroxyapatite composite materials, hydroxyapatite generally It exists in two forms, one is coated on the surface of the magnesium alloy with a thin film, and the other is distributed in the interior of the magnesium alloy in a granular form. Such hydroxyapatite cannot exist in a porous form, and the hydroxyapatite cannot be guaranteed The two-connected nature of the composite material, that is, when the magnesium alloy in the composite material is degraded, the hydroxyapatite structure will fall apart and cannot function, and its osteoinductivity is limited

Method used

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  • Magnesium or magnesium alloy-porous hydroxyapatite composite and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] In this example, porous hydroxyapatite is prepared by the organic foam method, and its pore size is 300 microns; the magnesium alloy is AZ91, and the magnesium alloy-porous hydroxyapatite composite material is prepared by the following method:

[0030] (1) Preheating: Put the porous hydroxyapatite (HA) into the mold, and then preheat both the porous hydroxyapatite and the mold to 400°C;

[0031] (2) The magnesium alloy melt penetrates into the pores of porous hydroxyapatite: the magnesium alloy is melted, and the obtained magnesium alloy melt is added to the above-mentioned mold, and then extrusion casting is performed to infiltrate the magnesium alloy melt into the In the pores of the porous hydroxyapatite, the pressure head of the squeeze casting applies a first pressure during the process, and the first pressure does not exceed 10Mpa, so as to ensure that the porous hydroxyapatite is not broken; wherein, the melting of the magnesium alloy One step can be carried out ...

Embodiment 2

[0036] In this example, porous hydroxyapatite was prepared by the organic foam method, and its pore size was 100 microns; the magnesium alloy was Mg-Nd-Zn-Zr magnesium alloy, and the magnesium alloy-porous hydroxyapatite composite material was prepared by the following method:

[0037] (1) Preheating: Put the porous hydroxyapatite into the mold, and then preheat both the porous hydroxyapatite and the mold to 500°C;

[0038] (2) The magnesium alloy melt penetrates into the pores of porous hydroxyapatite: the magnesium alloy is melted, and the obtained magnesium alloy melt is added to the above-mentioned mold, and then extrusion casting is performed to infiltrate the magnesium alloy melt into the In the pores of the porous hydroxyapatite, the pressure head of the extrusion casting applies a first pressure during the process, and the first pressure does not exceed 10Mpa, so as to ensure that the porous hydroxyapatite is not broken; wherein, the melting of the magnesium alloy One ...

Embodiment 3

[0042]In this example, porous hydroxyapatite was prepared by the organic foam method, and its pore size was 50 microns; the magnesium alloy was made of pure magnesium, and the magnesium alloy-porous hydroxyapatite composite material was prepared by the following method:

[0043] (1) Preheating: Put the porous hydroxyapatite into the mold, and then preheat both the porous hydroxyapatite and the mold to 450°C;

[0044] (2) Magnesium melt penetrates into the pores of porous hydroxyapatite: Magnesium is melted, and the obtained magnesium melt is added to the above mold, and then extrusion casting is performed to infiltrate the magnesium melt into the porous hydroxyapatite In the pores of the stone, in the process, the pressure head of the extrusion casting applies the first pressure, and the first pressure does not exceed 10Mpa, so as to ensure that the porous hydroxyapatite is not broken; wherein, the melting step of magnesium can be related to the first ( 1) Steps are carried ou...

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Abstract

The invention discloses a magnesium or magnesium alloy-porous hydroxyapatite composite and an extrusion casting preparation technology thereof. Aperture selection of the porous hydroxyapatite satisfies hundreds of micrometers required by clinical bone repair. In an extrusion casting process, smaller pressure is applied by a pressure head, so that a magnesium or magnesium alloy fusant is impregnated into pores of the porous hydroxyapatite, and then larger pressure is applied in a solidification process of the magnesium or magnesium alloy fusant, so that a structure of solidified magnesium or a solidified magnesium alloy is controlled. The magnesium or magnesium alloy-porous hydroxyapatite composite ensures double connectivity of the porous hydroxyapatite; magnesium or the magnesium alloy filled in the pores of the porous hydroxyapatite improves the strength; fracture of a structure of the porous hydroxyapatite is avoided; when the composite is used in the field of bone repair, the structure of the porous hydroxyapatite can still keep complete while magnesium or the magnesium alloy is degraded; bone cells can be induced to grow into multiple pores; and new bone forming is facilitated.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical bone repair material and a preparation method thereof. Background technique [0002] Magnesium alloy-porous hydroxyapatite composites can be used as biodegradable medical bone repair materials. Traditional bone repair materials have various problems. Some materials have poor biocompatibility; The problem of insufficient strength, such as polymer materials. Magnesium alloy has outstanding characteristics such as good biocompatibility, low density and high strength, self-degradation, elastic modulus similar to human bone, etc. The disadvantage of poor induction. Porous hydroxyapatite (HA) is a commonly used biomedical material nowadays. It has good biocompatibility and its structure is similar to human bones and teeth. However, its texture is brittle and easily broken, which is far from meeting the needs of long-term implantation. [0003] In order to solve the probl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C23/00B22D19/00
Inventor 陈彬卢天风尹恺阳孙秉毅董晴
Owner SHANGHAI JIAO TONG UNIV
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