Vesicle composition, and external skin preparation and cosmetic, each containing same

A technology of composition and vesicles, applied in the field of skin external preparations and cosmetics, can solve problems such as long-term stability limitation, and achieve the effect of excellent long-term stability

Active Publication Date: 2013-05-01
KOBAYASHI KOSE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since phospholipids are easily affected by pH, temperature, and electrolytes, etc., there are many limitations in long-term stability (for example, non-patent document 1)

Method used

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  • Vesicle composition, and external skin preparation and cosmetic, each containing same
  • Vesicle composition, and external skin preparation and cosmetic, each containing same
  • Vesicle composition, and external skin preparation and cosmetic, each containing same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0078]The method for preparing the vesicle composition of the present invention is not particularly limited, and it can be prepared by a common method. For example, it can be prepared by the following methods: vortexing method [A.D.Bangham, J.Mol.Biol., 13, 238 (1965)], sonication method [C.Huang, Biochem., 8, 344 (1969)], pretreatment Vesicle method (prevesicle method) [H. Trauble, Neurosci. Res. Prog. Bull., 9, 273 (1971)], ethanol injection method [S. Batzri, Biochem. Biophys. French Crusher extrusion method [Y.Barenholz, FEBS Lett., 99,210(1979)], bile acid removal method [Y.Kagawa, J.Biol.Chem., 246,5477(1971)], TritonX-100 Batch method [W.J.Gerritsen, Eur.J.Biochem., 85,255 (1978)], Ca 2+ Fusion method [D.Papahadojopoulos, Biochem.Biophys.Acta., 394,483 (1975)], ether injection method [D.Deazer, Biochem.Biophys.Acta., 443,629 (1976)], annealing method [R.Lawaczeck, Biochem. Biophys.Acta., 443,313(1976)], freeze-thaw fusion method [M.Kasahara, J.Biol.Chem., 252,7384(197...

Embodiment

[0104] Hereinafter, examples and test examples are given to specifically describe the present invention, but the present invention is not limited to these examples and the like.

[0105] [Vesicle composition of Examples 1 to 15]

[0106] Using the components shown in the columns of Examples 1 to 15 in Table 1, a vesicle composition was prepared by the following production method.

[0107] In addition, for the vesicle composition of Example 13 ( image 3 Sample B), except changing the vesicle composition of Example 2 ( image 3 Sample A) was prepared in the same manner as in Example 2 except for the contents of component (A) polyoxyethylene (5 mol) phytosterol, component (B) batyl alcohol, and component (C) cholesterol.

[0108] Step 1: The components selected from components 1 to 17 are heated to 95° C. to form a solution.

[0109] Step 2: Purified water was added to the solution obtained in Step 1 while maintaining the temperature at 75° C., and a dispersion liquid was obt...

Embodiment 16

[0160] Embodiment 16: ointment

[0161] The ointment is prepared by the following ingredients and production method.

[0162]

[0163] (Note 1) Manufactured by Wako Pure Chemical Industries, Ltd.

[0164] (Note 2) Manufactured by Eisai Co., Ltd.

[0165] (Production method)

[0166] A: A part of ingredients (3), (4) and (9) was heated and mixed, and kept at 75°C.

[0167] B: Components (1), (2), (7), and (8) were heated and mixed, and kept at 75°C.

[0168] C: B is slowly added to A, and (5) dissolved with the remainder of component (9) is added while cooling, and component (6) is further added to obtain an ointment.

[0169] The ointment of Example 16 was excellent in the stability of the vesicle composition.

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Abstract

[Problem] To provide a vesicle composition having excellent stability over time, and an external skin preparation and a cosmetic, each containing the same. [Solution] [1] A vesicle composition comprising a vesicle having a constituent membrane containing (A) an ether-based nonionic surfactant having a sterol skeleton and (B) a monoalkyl glyceryl ether. [2] An external skin preparation and a cosmetic, each comprising a vesicle composition containing a vesicle having a constituent membrane containing (A) an ether-based nonionic surfactant having a sterol skeleton and (B) a monoalkyl glyceryl ether.

Description

technical field [0001] The present invention relates to vesicle compositions, skin external preparations and cosmetics containing the same. Background technique [0002] Vesicles (closed vesicles having a bimolecular membrane structure formed of amphiphiles) have attracted attention as carriers for drug delivery systems and the like because they can contain active ingredients due to their specific structure. [0003] Phospholipids derived from living organisms are known as typical amphiphiles constituting the vesicles (see, for example, Patent Documents 1 and 2). In addition, vesicles formed of this phospholipid are called liposomes, and are naturally derived components, and many studies have been conducted from the viewpoint of safety to living organisms. However, phospholipids have many limitations in long-term stability because they are easily affected by pH, temperature, and electrolytes (for example, Non-Patent Document 1). Therefore, in Non-Patent Document 1, castor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/33A61K8/63A61K8/86A61K9/127A61K47/08A61K47/18A61K47/28A61K47/34A61Q19/00
CPCA61K8/14A61Q19/00A61K8/33A61K8/63A61K8/86A61K9/127A61K47/08
Inventor 田中章博
Owner KOBAYASHI KOSE CO LTD
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