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Adefovir dipivoxil pharmaceutical composition

A technology for adefovir dipivoxil and pharmaceutical preparations, applied in the field of medicine, can solve the problems of the influence of preparation stability, adefovir dipivoxil intolerance to humidity and heat, and the dissolution rate needs to be improved, and achieves excellent dispersion uniformity and excellent release properties. Effect

Active Publication Date: 2014-05-28
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN1546046A discloses the preparation of adefovir dipivoxil dispersible tablets by wet granulation and tabletting. Since adefovir dipivoxil is not resistant to heat and humidity, this method has a significant impact on the stability of the preparation, and the hardness and dissolution rate need to be improved
But the hardness of this adefovir dipivoxil dispersible tablet preparation needs to be improved, and the dissolution rate needs to be improved

Method used

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  • Adefovir dipivoxil pharmaceutical composition
  • Adefovir dipivoxil pharmaceutical composition
  • Adefovir dipivoxil pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]

[0041] Preparation method: Mix adefovir dipivoxil, anhydrous direct-pressed lactose-glyceryl monostearate, pregelatinized starch, hydroxypropyl cellulose and sodium carboxymethyl starch, and press the tablet.

Embodiment 2

[0043]

[0044] Preparation method: Mix adefovir dipivoxil, anhydrous direct-pressed lactose-glyceryl monostearate, pregelatinized starch, hydroxypropyl cellulose and sodium carboxymethyl starch, and press the tablet.

Embodiment 3

[0046]

[0047] Preparation method: Mix adefovir dipivoxil, anhydrous direct-pressed lactose-glyceryl monostearate, pregelatinized starch, hydroxypropyl cellulose and sodium carboxymethyl starch, and press the tablet.

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PUM

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Abstract

The invention discloses an oral adefovir dipivoxil pharmaceutical composition preparation resisting hepatitis B virus and a preparation method thereof. Based on the weight of the preparation, the pharmaceutical composition contains 1-15% of adefovir dipivoxil as the active component, 30-75% of anhydrous direct pressure lactose-glycerin monostearate, 10-45% of pregelatinized starch, 2-20% of hydroxy propyl cellulose and 0.5-10% of sodium carboxymethyl starch. The pharmaceutical composition is prepared by directly pressing powder into tablets. The adefovir dipivoxil dispersible tablet preparation prepared by the invention has excellent uniformity, dissolution and hardness. The invention further relates to an application of the preparation for resisting hepatitis B virus.

Description

Technical field [0001] The invention relates to an oral pharmaceutical composition for the treatment of hepatitis B virus infection, in particular to an oral pharmaceutical composition containing adefovir dipivoxil, anhydrous direct-pressed lactose-glyceryl monostearate, pregelatinized starch, and hydroxypropyl fiber The pharmaceutical preparation of sodium carboxymethyl starch and sodium carboxymethyl starch and a preparation method thereof belong to the technical field of medicine. Background technique [0002] According to relevant statistics, the clinical incidence of chronic hepatitis B is high. About 5% of the world's population are carriers of chronic hepatitis B virus (HBV). There are more than 30 million patients with chronic hepatitis B in my country. Hepatitis B virus (HBV) There are more than 100 million carriers. Chronic hepatitis B is the main cause of chronic liver disease, cirrhosis and liver cancer, and its morbidity and mortality are high, which seriously affect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/675A61K9/20A61P31/20
Inventor 王玮朱少璇陈矛廖维王健松汪茂先邹爱峰任金山邓淑渊
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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