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Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition

A technology for hypertension and composition, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve problems such as toxic side effects, difficulty in reducing blood pressure to an ideal level, etc., and achieve the effects of lowering blood pressure, improving blood lipid level, and achieving remarkable effects

Inactive Publication Date: 2013-05-08
INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the resistance of hypertension to western medicine, it is often difficult to lower the blood pressure to the ideal level with only western medicine, and because hypertension advocates life-long medication to reduce the damage of the disease to terminal organs, the resulting toxic and side effects are the patient's It is a common concern with doctors, so we are looking for treatment measures that can counteract the resistance of Western medicine to treat hypertension, enhance the clinical antihypertensive effect, or reduce the dosage of Western medicine or even withdraw Western medicine, regardless of the effectiveness and rationality of the treatment of hypertension. It has clinical significance for in-depth research in highlighting the curative effect advantages of traditional Chinese medicine and reducing medical expenses

Method used

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  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition
  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition
  • Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition

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Effect test

experiment example 1

[0052] 1 Materials and methods

[0053] 1.1 Case selection

[0054] 1.1.1 Western Medicine Diagnostic Criteria

[0055] The diagnosis of hypertension refers to the 1999 World Health Organization and International Society of Hypertension (WHO / ISH) Guidelines for the Management of Hypertension (The Fourth Revised Edition); the staging standard of hypertension is based on the World Health Organization staging standard, and hypertension can be divided into 3rd issue.

[0056] 1.1.2 Diagnostic criteria of TCM syndromes

[0057] Phlegm and blood stasis, toxic damage to the heart and collaterals syndrome: Main symptoms: dizziness, headache, head wrapping, chest tightness, chest pain, cough and spit saliva, dark lips and nails, and bruising of sublingual collaterals. Dark tongue with petechiae or ecchymosis, white and greasy fur, slippery or dull pulse or knot. Secondary symptoms: palpitations, insomnia, light mouth, lack of food, body fat.

[0058] 1.1.3 Case inclusion criteria ...

Embodiment 1

[0095] The crude drug composition of the traditional Chinese medicine composition of the present invention is composed of:

[0096] Chuanxiong 10g, Alisma 10g, Raisin 10g, Seaweed 15g, Leech 5g

[0097] The preparation method of traditional Chinese medicine composition of the present invention comprises the following steps:

[0098] A. Chuanxiong percolation method

[0099] The crude drug of Chuanxiong was taken and washed, crushed into coarse powder, immersed in 40% ethanol for 48 hours, collected and collected 600 ml of the initial exudate, and the remaining exudate was dipped until the exudate reached 4 times the volume of the crude drug, and the ethanol was recovered by distillation. ℃ concentrated into a thick paste, add the initial exudate, stir to dissolve, adjust the total extract, calculate the content of ligustrazine and ferulic acid, the content per ml is 0.28mg, let stand for 96h, take the supernatant for filtration, precipitate water Decoction and alcohol precip...

Embodiment 2

[0104] The crude drug composition of the traditional Chinese medicine composition of the present invention is composed of:

[0105] Chuanxiong 8g, Alisma 6g, Raisin 16g, Seaweed 14g, Leech 5g

[0106] The preparation method of the traditional Chinese medicine composition of the present invention comprises the following steps:

[0107] A. Chuanxiong percolation method

[0108]Take the crude drug of Chuanxiong and wash it, crush the coarse powder, use 35% ethanol as a solution, soak for 55 hours, collect 700ml of the initial exudate, and distill the rest until the exudate reaches 3 times the volume of the crude drug, and recover the ethanol by distillation. ℃ concentrated into a thick paste, add the initial exudate, stir evenly to dissolve, adjust the total extract content, calculate the content of ligustrazine and ferulic acid, the content per ml is 0.32mg, let stand for 100h, take the supernatant and filter, medicine The slag was decoction and alcohol precipitation, filtered...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating level-1 and level-2 hypertension and a preparation method of the composition. The traditional Chinese medicine composition for treating level-1 and level-2 hypertension is characterized by comprising the following raw medical materials: ligusticum wallichii, rhizoma alismatis, semen raphani, seaweed and leech; and the traditional Chinese medicine composition is prepared through the steps of decocting, carrying out alcohol precipitation and the like for the raw medicinal liquid with the preparation amount. The traditional Chinese medicine composition has remarkable therapeutic effects on the level-1 and level-2 hypertension, not only reduces blood pressure, but also improves blood grease level of a patient and the hemorheology, increases a heart function, and is good for correcting disordered lipid metabolism of the patient. The preparation method is simple and good for production, and has no side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicinal composition for treating grade 1 and 2 hypertension and a preparation method thereof. Background technique [0002] Hypertension is a systemic disease characterized by increased arterial pressure in the systemic circulation, which may be accompanied by functional or organic changes in organs such as the heart, blood vessels, brain, and kidneys. The greatest danger of high blood pressure is the occurrence of cardiovascular disease. At present, there are about 1.2 billion people with hypertension in the world. Among the hypertensive patients aged 40 to 70 years, the risk of cardiovascular disease increases twice for every 20mmHg increase in systolic blood pressure or every 10mmHg increase in diastolic blood pressure. In the past half century, the prevalence of hypertension in the Chinese population has in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P9/12A61K35/62
Inventor 韩学杰沈绍功
Owner INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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